期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 952, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2021.122032
关键词
Iridium (III); Ferrocene; Electrochemistry; Antimicrobial studies; Cytotoxicity
资金
- DST, WOS-A scheme [SR/WOS-A/CS-21/2016]
- RUSA-Phase 2.0 grant [F. 24-51/2014-U]
- Department of Education, Govt. of India
- DST-PURSE-II New Delhi
Three newly synthesized ferrocene-appended cyclometalated iridium(III) complexes showed promising antimicrobial activities against various bacteria and fungi, with complexes 1 and 2 exhibiting strong bactericidal and fungicidal effects. In addition, complex 1 displayed the highest cytotoxicity against HepG2 cancer cells among all the synthesized complexes.
Three newly synthesized ferrocene appended cyclometalated iridium(III) complexes (1, 2 and 3) were characterized by FT-IR, H-1 and C-13 NMR, LCMS spectroscopies and elemental analysis. The electrochemical studies suggested that all of the ferrocene appended iridium complexes exhibited two quasi-reversible one-electron oxidations. The antimicrobial activities of samples were evaluated against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli) and a fungal strain (Candida albicans). The complex 1 and 2 showed a significant zone of inhibition with potent bactericidal and fungicidal activities. The cytotoxic effects of the synthesized complexes (1-3) were studied by the MTT method against two different human cell lines (normal kidney cell line HEK293 and liver cancer cell line HepG2). The complex 1 showed the best cytotoxicity against HepG2 cancer cells among all the synthesized complexes. (C) 2021 Elsevier B.V. All rights reserved.
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