Article
Computer Science, Cybernetics
Chinedu Wilfred Okonkwo, Magda Huisman, Estelle Taylor
Summary: The development and use of homegrown mobile applications in Africa have significant impacts on the growth of various countries, with the extent varying depending on each country's adoption capability. A survey and data analysis revealed six areas where these apps influence Africa's development, showcasing differences in impact scale across selected countries.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2021)
Article
Law
Sahar F. Aziz
Summary: This article discusses the relationship between freedom of speech and law enforcement, specifically focusing on the double standards applied to Muslim communities. The author argues that the government's counterterrorism efforts disproportionately target Muslim communities, leading to unfair treatment. Meanwhile, the threats posed by far-right extremist groups have not received enough attention.
GEORGETOWN LAW JOURNAL
(2023)
Article
Food Science & Technology
Bulus Barnabas, Sylvester Amoako Agyemang, Edwin Zhllima, Miroslava Bavorova
Summary: In various countries of the global south, school feeding programs are implemented to alleviate short-term hunger in children, improve their nutrition, and provide employment opportunities for food vendors. These programs have a significant impact on pupils' nutrition, as well as improving farmers' livelihoods, productivity, and food security.
Article
Psychology, Clinical
Brandon R. McFadden, Trey Malone
Summary: A study on public perceptions of cannabinoids found that more than half of U.S. adult respondents believed CBD, THC, hemp, and marijuana have medical benefits with lower potential for abuse compared to commonly prescribed medications. Participants also viewed CBD and hemp similarly to over-the-counter pain relief medications, and did not classify marijuana as a Schedule I substance.
ADDICTIVE BEHAVIORS
(2021)
Article
Medicine, Research & Experimental
Ting Jiang, Hongji Zhang, Yiming Li, Preethi Jayakumar, Hong Liao, Hai Huang, Timothy R. Billiar, Meihong Deng
Summary: TLR9 agonist can enhance the efficacy of anti-PD-1 therapy for colorectal peritoneal metastases by suppressing retinoid metabolism genes expression, reducing PRMs numbers, and enhancing CD8+ T cell antitumor immunity.
Article
Multidisciplinary Sciences
Chao Mi, Xun Zhang, Chengyu Yang, Jianqun Wu, Xinxin Chen, Chenguang Ma, Sitong Wu, Zhichao Yang, Pengzhen Qiao, Yang Liu, Weijie Wu, Zhiyong Guo, Jiayan Liao, Jiajia Zhou, Ming Guan, Chao Liang, Chao Liu, Dayong Jin
Summary: Researchers have developed a high-resolution near-infrared-II (NIR-II) imaging method for non-invasive diagnosis of skeletal disorders. By using lanthanide-doped nanocrystals, they were able to passively target the bone marrow and achieve effective bone imaging for over two months. The NIR-II imaging technique showed comparable results to X-ray imaging and could also diagnose early onset inflammation in rheumatoid arthritis.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Christof Vorsatz, Niklas Friedrich, Falk Nimmerjahn, Markus Biburger
Summary: The effector functions of antibodies rely on the binding to cellular Fc gamma receptors, including tissue-resident macrophages. These macrophages play a crucial role in clearing pathogens, immune complexes, and in therapeutic interventions, with a pronounced heterogeneity in Fc gamma receptor expression patterns among different tissue macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Christian D. Ortiz-Robles, Vanessa Cortes-Montoya, Sandra S. Reyes-Aguilar, Arnulfo Albores, Emma S. Calderon-Aranda
Summary: Lead exposure alters functional outcomes and phenotypic markers of macrophages, especially the anti-inflammatory phenotype, with effects on specific pathways differing between inflammatory and anti-inflammatory cells.
Article
Oncology
Sherko Kuemmel, Mario Campone, Delphine Loirat, Rafael Lopez Lopez, J. Thaddeus Beck, Michelino De Laurentiis, Seock-Ah Im, Sung-Bae Kim, Ava Kwong, Guenther G. Steger, Esther Zamora Adelantado, Francois P. Duhoux, Richard Greil, Irene Kuter, Yen-Shen Lu, Ariadna Tibau, Mustafa Ozguroglu, Christian W. Scholz, Christian F. Singer, Estela Vega, Pauline Wimberger, Claudio Zamagni, Xuan-Mai Couillebault, Liqiong Fan, Nelson Guerreiro, Jennifer Mataraza, Janna Sand-Dejmek, Arlene Chan
Summary: This phase II study aimed to evaluate the efficacy of lacnotuzumab added to gemcitabine plus carboplatin in patients with advanced triple-negative breast cancer. The results showed that lacnotuzumab + gem-carbo had comparable antitumor activity to gem-carbo alone, but with slightly poorer tolerability.
CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Ming Yun Yu, Hui Jie Jia, Jing Zhang, Guang He Ran, Yan Liu, Xiu Hong Yang
Summary: Macrophages are immune cells that are highly diverse and flexible, and play a crucial role in fighting against pathogens and tumor cells. They can polarize into M1 phenotype to exert pro-inflammatory effects or M2 phenotype to exert anti-inflammatory effects in response to different stimuli. The balance of macrophage polarization is closely associated with disease progression, and therapeutic approaches targeting macrophage polarization are feasible.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhu-Lin Luo, Hong-Yu Sun, Xiao-Bo Wu, Long Cheng, Jian-Dong Ren
Summary: The study demonstrated that EGCG can significantly attenuate lung injury during acute pancreatitis by inhibiting NLRP3 inflammasome activation. The mechanism is mainly attributed to the elimination of mtROS and its oxidative product ox-mtDNA, thus providing protection against AP-associated lung injury.
Article
Immunology
Christina Draijer, Laura Florez-Sampedro, Catharina Reker-Smit, Eduard Post, Fransien van Dijk, Barbro N. Melgert
Summary: This study investigates the development of differentially polarized macrophages, specifically YM1+ and MHCII+ macrophages, in the development of house dust mite-induced allergic lung inflammation in mice. The findings suggest that the proliferation of nonpolarized tissue-resident macrophages and the recruitment of monocytes contribute to the development of a polarized macrophage pool during allergic inflammation. The polarization of macrophages is characterized by the upregulation of YM1 on alveolar macrophages and MHCII on interstitial macrophages.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Jingwei Dong, Jing Lu, Zhihong Cen, Quan Tang, Yong Li, Lin Qin, Yuluan Yan, Feiyu Lu, Weifeng Wu
Summary: This study found that BALB/c mice have prolonged accumulation of monocyte-derived macrophages (MoMFs) and low proportions of embryonic-derived resident macrophages (ResMfs) in acute viral myocarditis. Selective depletion of MoMFs improved acute myocarditis and chronic fibrosis, restored ResMfs number, and reduced CD4+ T cell expansion. Therefore, modulating the balance and function of cardiac macrophages could prevent the progression of cardiac injury to heart failure and improve adverse outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Urology & Nephrology
Haojia Wu, Benjamin D. Humphreys
Summary: In this study, Fu et al. generate a large immune cell single-cell RNA-sequencing atlas using a flow sorting strategy in a mouse model of diabetic kidney disease. These findings highlight the importance of leukocyte cell subtypes in diabetic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Review
Immunology
Amelia Kulle, Ajitha Thanabalasuriar, Taylor S. Cohen, Marta Szydlowska
Summary: Resident macrophages play a crucial role in tissue maintenance by defending against pathogens and regulating inflammatory tone and tissue structure. This review focuses on the developmental origin of liver and lung resident macrophages, their contribution to host defense, and the mechanisms they use to regulate tissue homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhenghui Liu, Nan Zhang, Bojing Shao, Sumith R. Panicker, Jianxin Fu, Rodger P. McEver
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Immunology
Tadayuki Yago, Brian G. Petrich, Nan Zhang, Zhenghui Liu, Bojing Shao, Mark H. Ginsberg, Rodger P. McEver
JOURNAL OF EXPERIMENTAL MEDICINE
(2015)
Article
Hematology
Nan Zhang, Zhenghui Liu, Longbiao Yao, Padmaja Mehta-D'souza, Rodger P. McEver
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Article
Multidisciplinary Sciences
Zhenghui Liu, Tadayuki Yago, Nan Zhang, Sumith R. Panicker, Ying Wang, Longbiao Yao, Padmaja Mehta-D'souza, Lijun Xia, Cheng Zhu, Rodger P. McEver
NATURE COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Longbiao Yao, Janet Heuser-Baker, Oana Herlea-Pana, Nan Zhang, Luke I. Szweda, Timothy M. Griffin, Jana Barlic-Dicen
Article
Biochemistry & Molecular Biology
Ying Wang, Tadayuki Yago, Nan Zhang, Salim Abdisalaam, George Alexandrakis, William Rodgers, Rodger P. McEver
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Virology
Jie Lu, Wanyin Tao, Rui Li, Yu Xiang, Nan Zhang, Xiaogang Xiang, Qing Xie, Jin Zhong
Article
Immunology
Nan Zhang, Rafael S. Czepielewski, Nicholas N. Jarjour, Emma C. Erlich, Ekaterina Esaulova, Brian T. Saunders, Steven P. Grover, Audrey C. Cleuren, George J. Broze, Brian T. Edelson, Nigel Mackman, Bernd H. Zinselmeyer, Gwendalyn J. Randolph
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Immunology
Bojing Shao, Tadayuki Yago, Sumith R. Panicker, Nan Zhang, Zhenghui Liu, Rodger P. McEver
JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Samantha Hsieh, Nathan T. Porter, David L. Donermeyer, Stephen Horvath, Gregory Strout, Brian T. Saunders, Nan Zhang, Bernd Zinselmeyer, Eric C. Martens, Thaddeus S. Stappenbeck, Paul M. Allen
JOURNAL OF IMMUNOLOGY
(2020)
Article
Medicine, General & Internal
Sandeep Dhindsa, Nan Zhang, Michael J. McPhaul, Zengru Wu, Amit K. Ghoshal, Emma C. Erlich, Kartik Mani, Gwendalyn J. Randolph, John R. Edwards, Philip A. Mudd, Abhinav Diwan
Summary: This study found that lower testosterone concentrations in male COVID-19 patients were associated with increased disease severity and inflammation. Estradiol and IGF-1 concentrations were not associated with COVID-19 severity in men. Changes in hormone signaling pathways in monocytes may not correspond to the severity of the disease in COVID-19 patients.
Article
Immunology
Nan Zhang, Seung Hyeon Kim, Anastasiia Gainullina, Emma C. Erlich, Emily J. Onufer, Jiseon Kim, Rafael S. Czepielewski, Beth A. Helmink, Joseph R. Dominguez, Brian T. Saunders, Jie Ding, Jesse W. Williams, Jean X. Jiang, Brahm H. Segal, Bernd H. Zinselmeyer, Gwendalyn J. Randolph, Ki-Wook Kim
Summary: Two resident macrophage subsets were identified in the mesenteric and parietal mesothelial linings of the peritoneum, with one subset of LYVE1(hi) mesothelial macrophages independently driving tumor growth. These findings suggest a previously unknown role for mesothelial macrophages in peritoneal tumor development.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Hematology
Tadayuki Yago, Nan Zhang, Liang Zhao, Charles S. Abrams, Rodger P. McEver
Article
Hematology
Sumith R. Panicker, Padmaja Mehta-D'souza, Nan Zhang, Arkadiusz G. Klopocki, Bojing Shao, Rodger P. McEver