Article
Immunology
Casper J. E. Wahlund, Safak Caglayan, Paulo Czarnewski, John-Bjarne Hansen, Omri Snir
Summary: Venous thromboembolism (VTE) is a major cause of preventable deaths in hospitals, and its incidence is not decreasing despite extensive efforts in clinical and laboratory research. In the valve pockets of deep veins, activated monocytes play a crucial role in bridging innate immune activation and hemostatic pathways through the production of inflammatory cytokines, chemokines, and tissue factor (TF) - a principal initiator of coagulation. The combined effects of inflammation and hypoxia on immunothrombotic processes are poorly understood. Inflammation is strongly associated with VTE, while the additional contribution of hypoxia remains largely unexplored.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Kai Chen, Qiuping Hu, Zhongcong Xie, Guang Yang
Summary: This study reveals that surgery leads to neuronal hypoactivity and impairs learning-dependent dendritic spine formation, resulting in deficits in multiple learning tasks. These neuronal and synaptic alterations are mediated by peripheral monocytes through NLRP3 inflammasome-dependent IL-1β production. Decreasing peripheral monocytes or inactivating NLRP3 inflammasomes can reduce IL-1β levels and improve neuronal and behavioral deficits.
Article
Biochemistry & Molecular Biology
Marilia Freire, Antonio Bollig, Markus Knaden
Summary: The elements in the drawings are recyclable and reusable materials, which can be used by artificial intelligence to generate new drawing designs.
Review
Virology
Mahmoud M. Yaseen, Nizar M. Abuharfeil, Homa Darmani
Summary: IL-1 beta plays a crucial role in promoting HIV-1 replication, driving immune cell depletion, and chronic immune activation. Abnormal elevation in IL-1 beta levels is associated with disease progression. Targeting IL-1 beta as a therapeutic strategy is worth exploring.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Hae-Ri Lee, Young-Jin Jeong, Joong-Woon Lee, JooYeon Jhun, Hyun Sik Na, Keun-Hyung Cho, Seok Jung Kim, Mi-La Cho, Tae-Hwe Heo
Summary: The study revealed that tannic acid (TA) inhibits IL-1 beta-induced inflammation and matrix degradation in human OA chondrocytes by blocking IL-1 beta-IL-1R1 interaction. In addition, TA showed protective effects in a rat OA model by reducing pain, cartilage degradation, and IL-1 beta-mediated inflammation.
Article
Pharmacology & Pharmacy
Ching-Kai Shen, Bor-Ren Huang, Wei-Lan Yeh, Chao-Wei Chen, Yu-Shu Liu, Sheng-Wei Lai, Wen-Pei Tseng, Dah-Yuu Lu, Cheng-Fang Tsai
Summary: This study showed that IL-1 beta induces the expression of ICAM-1 and VCAM-1 in GBM cells, leading to increased adhesive interaction between monocytes and GBM cells. Additionally, IL-1 beta also triggers the production of soluble ICAM-1 and VCAM-1 in GBM, which plays a crucial role in regulating tumor-associated monocyte/macrophage polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Sandy ElSayed, Gregory D. Jay, Ralph Cabezas, Marwa Qadri, Tannin A. Schmidt, Khaled A. Elsaid
Summary: The study revealed that monocytes from acute gout patients exhibited higher phagocytic activation and ROS generation under basal conditions, as well as increased IL-1 beta secretion upon MSU stimulation. rhPRG4 showed better inhibition of phagocytic activation in monocytes from both normal and gout patients compared to IL-1RA, and both treatments effectively reduced IL-1 beta secretion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lisha Luo, Shuanglinzi Deng, Wei Tang, Xinyue Hu, Feifei Yin, Huan Ge, Jiale Tang, Zhonghua Liao, Xiaozhao Li, Juntao Feng
Summary: This study found a significant increase in CD14(++)CD16(+) intermediate monocytes in the pleural effusion of MPE patients. The classical and alternative pathways of the complement system were highly expressed in malignant pleural tissue. C5a not only promoted the infiltration of intermediate monocytes into the pleural cavity by enhancing CCL2 production, but also induced IL-1 beta release from the recruited monocytes, contributing to MPE progression.
Article
Biochemistry & Molecular Biology
Jialing Shen, Ming Zhao, Chunxiang Zhang, Xiaolei Sun
Summary: Atherosclerotic vascular calcification is associated with increased risk of death in patients with cardiovascular diseases. IL-1 beta plays diverse roles in the pathogenesis of this condition, and anti-IL-1 beta therapy has shown to reduce the incidence of cardiovascular events, though the underlying mechanism remains unclear. This review summarizes current knowledge and clinical trial results on the role of IL-1 beta in atherosclerotic vascular calcification.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Max Wacker, Anna Ball, Hans-Dietmar Beer, Ingo Schmitz, Katrin Borucki, Faranak Azizzadeh, Maximilian Scherner, George Awad, Jens Wippermann, Priya Veluswamy
Summary: Multivessel coronary artery disease (CAD) is characterized by chronic vascular inflammation and occlusion in the coronary arteries. This study aimed to investigate the inflammation levels and cytokine production in preoperative and postoperative CAD patients, and to intervene with selenium to reduce inflammation. It was found that postoperative CAD patients had higher levels of pro-inflammatory cytokines and CCR1(high) monocytes. In vitro intervention with selenium demonstrated mitigating effects on IL-6/STAT-3 axis and reduced IL-1 beta production and caspase-1 activity. However, selenium had no obvious effect on the TNF-alpha/NF-kappa B axis. Overall, selenium could be used to reduce systemic inflammation and protect bypass grafts during the post-surgical period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Lipeng Tang, Tong Li, Bowen Zhang, Zihao Zhang, Xiaoyi Sun, Ying Zhu, Bing Feng, Zuqing Su, Laijun Yang, Hongxia Li, Huazhen Liu, Yuchao Chen, Zhenhua Dai, Xirun Zheng, Mingxian Li, Chutian Li, Jie Zhao, Xinmin Qiu, Shuyan Ye, Han Liu, Guangjuan Zheng, Ben Li, Chuanjian Lu
Summary: Punicalagin (PUN) shows therapeutic potential for psoriasis by inhibiting inflammatory response and cell signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yaoyao Xia, Fang He, Xiaoyan Wu, Bie Tan, Siyuan Chen, Yuexia Liao, Ming Qi, Shuai Chen, Yuanyi Peng, Yulong Yin, Wenkai Ren
Summary: Accumulating evidence suggests that the GABAergic system, specifically GABA transporter 2 (GAT2), plays a crucial role in modulating macrophage function. GAT2 deficiency leads to decreased IL-1β production in proinflammatory macrophages by altering metabolic pathways and DNA methylation. Targeting GABAergic system, such as GAT2, may offer new therapeutic opportunities for macrophage-related diseases.
Article
Nanoscience & Nanotechnology
Meimei Zhang, Runlin Zhang, Hui Chen, Xiaofeng Zhang, Yilei Zhang, Haining Liu, Chen Li, Yunhua Chen, Qing Zeng, Guozhi Huang
Summary: In this study, a thermosensitive injectable supra-molecular hybrid hydrogel was developed to deliver interleukin-1β-stimulated exosomes derived from bone marrow stromal cells (BMSCs) for neuroinflammation inhibition and neurological recovery after cerebral ischemia-reperfusion injury (CIRI). The hydrogel showed self-healing and injectable properties, as well as high biocompatibility and softness similar to tissue. The released exosomes effectively reduced inflammatory responses in microglia cells and improved retention in the ischemic core area, leading to reduced glial scar formation and neuronal loss in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Neurosciences
Jingrui Pan, Jialing Peng, Xiangpen Li, Hongxuan Wang, Xiaoming Rong, Ying Peng
Summary: This study reveals that microglia activate NLRP3 inflammasomes in neurons and endothelial cells via IL-1 beta/IL-1R1/TRAF6 signaling pathway, promoting cerebral ischemia and reperfusion injury. Inhibition of IL-1R1 can block inflammatory damage and prevent excessive infiltration of leukocytes into the brain, leading to better neurological outcome.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xin Huang, Changhong Chen, Yaofei Chen, Jun Xu, Lin Liu
Summary: This study found that Omentin-1 plays an important role in inhibiting inflammation-associated cellular aging in intervertebral disc degeneration, and may be a candidate for IVDD gene target therapy.
Article
Immunology
Emma E. Hornick, Balaji Banoth, Ann M. Miller, Zeb R. Zacharias, Nidhi Jain, Mary E. Wilson, Katherine N. Gibson-Corley, Kevin L. Legge, Gail A. Bishop, Fayyaz S. Sutterwala, Suzanne L. Cassel
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Eric I. Elliott, Alexis N. Miller, Balaji Banoth, Shankar S. Iyer, Aleksandr Stotland, Jerrold P. Weiss, Roberta A. Gottlieb, Fayyaz S. Sutterwala, Suzanne L. Cassel
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Catherine E. Vrentas, Robert G. Schaut, Paola M. Boggiatto, Steven C. Olsen, Fayyaz S. Sutterwala, Mahtab Moayeri
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2018)
Editorial Material
Microbiology
Hengameh Sadeghi, Suzanne Devkota, Fayyaz S. Sutterwala
CELL HOST & MICROBE
(2018)
Article
Respiratory System
Jenieke R. Allen, Lingyin Ge, Ying Huang, Rena Brauer, Tanyalak Parimon, Suzanne L. Cassel, Fayyaz S. Sutterwala, Peter Chen
Article
Medical Laboratory Technology
Balaji Banoth, Suzanne L. Cassel
TRANSLATIONAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Ryan Kolb, Paige Kluz, Zhen Wei Tan, Nicholas Borcherding, Nicholas Bormann, Ajaykumar Vishwakarma, Louis Balcziak, Pengcheng Zhu, Brandon S. J. Davies, Francoise Gourronc, Ling-Zhi Liu, Xin Ge, Bing-Hua Jiang, Katherine Gibson-Corley, Aloysius Klingelhutz, Nguan Soon Tan, Yuwen Zhu, Fayyaz S. Sutterwala, Xian Shen, Weizhou Zhang
Article
Gastroenterology & Hepatology
Koichiro Ohashi, Zhijun Wang, Yoon Mee Yang, Sandrine Billet, Wei Tu, Michael Pimienta, Suzanne L. Cassel, Stephen J. Pandol, Shelly C. Lu, Fayyaz S. Sutterwala, Neil Bhowmick, Ekihiro Seki
Article
Infectious Diseases
Tiffany Y. Borbon, Breanna M. Scorza, Gwendolyn M. Clay, Fellipe Lima Nobre de Queiroz, Alan J. Sariol, Jayden L. Bowen, Yani Chen, Bayan Zhanbolat, Corey P. Parlet, Diogo G. Valadares, Suzanne L. Cassel, William M. Nauseef, Alexander R. Horswill, Fayyaz S. Sutterwala, Mary E. Wilson
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Medicine, Research & Experimental
Emma E. Hornick, Jargalsaikhan Dagvadorj, Zeb R. Zacharias, Ann M. Miller, Ryan A. Langlois, Peter Chen, Kevin L. Legge, Gail A. Bishop, Fayyaz S. Sutterwala, Suzanne L. Cassel
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Public, Environmental & Occupational Health
John-Ericson P. Margallo, Ethan A. Smith, Gregory Marks, Michael Ben-Aderet, Haoshu Yang, Meghan Madhusudhan, Sneha Krishna, Ann Duran, Arnold Friedman, Suzanne L. Cassel, Hai Tran, Rita Shane, Rekha K. Murthy, Jonathan D. Grein
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2019)
Article
Multidisciplinary Sciences
Jargalsaikhan Dagvadorj, Karolina Mikulska-Ruminska, Gantsetseg Tumurkhuu, Rojo A. Ratsimandresy, Jessica Carriere, Allen M. Andres, Stefanie Marek-Iannucci, Yang Song, Shuang Chen, Malcolm Lane, Andrea Dorfleutner, Roberta A. Gottlieb, Christian Stehlik, Suzanne Cassel, Fayyaz S. Sutterwala, Ivet Bahar, Timothy R. Crother, Moshe Arditi
Summary: The balance between NLRP3 inflammasome activation and mitophagy is crucial for cellular homeostasis, with IL-1 alpha playing a key role in regulating this balance. IL-1 alpha deficiency can lead to altered cellular functions and health by affecting mitochondrial damage and NLRP3 inflammasome activation. The interaction between IL-1 alpha and mitochondrial cardiolipin disrupts mitophagy and enhances NLRP3 inflammasome activation, highlighting the importance of this regulatory mechanism in cellular health.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Andrew Sanchez, Eric Elliott, Peter Wang, Anne Spichler-Moffarah
Summary: This is a case report of a fully mRNA-vaccinated individual who presented with bacterial co-infections alongside COVID-19. The patient initially showed symptoms more consistent with Legionnaire's disease rather than severe COVID-19, including pneumonia, hyponatremia, and rhabdomyolysis. The successful recovery of the patient highlights the importance of considering bacterial co-infections in COVID-19 patients, as the use of immunosuppressive COVID-19 therapies may result in worse outcomes.
Meeting Abstract
Immunology
Emma Hornick, Balaji Banoth, Ann Miller, Zeb Ralph Zacharias, Nidhi Jain, Mary E. Wilson, Katherine Gibson-Corley, Kevin L. Legge, Gail A. Bishop, Fayyaz S. Sutterwala, Suzanne Cassel
JOURNAL OF IMMUNOLOGY
(2018)
