Article
Biology
Alistair M. Senior, Veronique Legault, Francis B. Lavoie, Nancy Presse, Pierrette Gaudreau, Valerie Turcot, David Raubenheimer, David G. Le Couteur, Stephen J. Simpson, Alan A. Cohen
Summary: Using a multidimensional approach to study the effects of nutrient intake on physiological dysregulation in an aged population, key patterns of specific nutrients associated with minimal biological ageing were identified.
Review
Cell Biology
Sonia Turrini, Bonnie Wong, Mark Eldaief, Daniel Z. Press, David A. Sinclair, Giacomo Koch, Alessio Avenanti, Emiliano Santarnecchi
Summary: As the global population ages, understanding healthy brain aging is vital for preserving cognitive abilities. This review provides a comprehensive look at anatomical changes in the aging brain, as well as modifiable risk factors for healthy aging. It also examines the cognitive profile of healthy older adults, discussing the decline in four cognitive factors and their neural substrate. Different cognitive trajectories in Alzheimer's Disease and successful agers with high cognitive reserve are explored. Effective interventions and strategies to promote cognitive reserve and delay cognitive decline are reviewed and proposed.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Inaki Permanyer, Francisco Villavicencio, Sergi Trias-Llimos
Summary: This study explores the variability in age-at-morbidity onset as an indicator to assess individuals' health deterioration and compression of morbidity. The global, regional, and national estimates of morbidity onset variability from 1990 to 2019 reveal a decrease in overall healthy lifespan inequality, except in high-income countries. Higher healthy lifespan inequality is observed in sub-Saharan Africa and south Asia, while lower inequality values are found in high-income countries and central and eastern Europe.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Brian T. Joyce, Tao Gao, Kalsea Koss, Yinan Zheng, Andres Cardenas, Jonathan Heiss, Allan Just, Kai Zhang, Linda van Horn, Norrina Bai Allen, Philip Greenland, Sheldon Cohen, Penny Gordon-Larsen, Colter Mitchell, Sara McLanahan, Lisa Schneper, Daniel Notterman, Sheryl L. Rifas-Shiman, Emily Oken, Marie-France Hivert, Robert Wright, Andrea Baccarelli, Donald Lloyd-Jones, Lifang Hou
Summary: This study examines the relationship between individual, parental, and neighborhood socioeconomic status and epigenetic age acceleration (EAA), and finds that paternal education is associated with EAA.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ivy Yan Zhao, Mu-Hsing Ho, Stefanos Tyrovolas, Sasha Yuanjie Deng, Jed Montayre, Alex Molassiotis
Summary: This study aimed to construct a healthy ageing index to verify the WHO healthy ageing framework, measure five domains of functional ability of older adults, and examine the relationship between functional ability domains and loneliness.
Review
Neurosciences
Jean-Philippe Leduc-Gaudet, Sabah N. A. Hussain, Gilles Gouspillou
Summary: Parkin is an E3 ubiquitin ligase that regulates the removal of defective mitochondria via mitophagy. It also plays key roles in mitochondrial biogenesis, dynamics, and vesicle formation. Parkin is not only found in the cytosol but also in the nucleus, where it regulates transcription factors. Overexpression of Parkin can delay aging, protect against neurological disorders, and suppress tumor growth.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Health Care Sciences & Services
Maria Isabella Gariboldi, Mengji Chen, Yuxin Wei, Shan Xu, Gauden Galea, Siwon Lee
Summary: Digital tools play a crucial role in addressing the health needs of ageing societies, but they often neglect older people. We developed the Avatar for Global Access to Technology for Healthy Ageing (Agatha), a user-centered digital platform to promote healthy ageing. Our vision for digital healthy ageing emphasizes a holistic approach, encompassing self-care, prevention, and active ageing, while considering social determinants of health in old age. By mapping out key areas of innovation and exploring policy priorities, we provide opportunities for practitioners in the field of digital innovation.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Public, Environmental & Occupational Health
T. (Patricia) Vella-Burrows, N. Ewbank, J. Philips
Summary: The study aims to understand the potential for public health agendas through public service local radio promoting creative engagement for healthy aging, drawing on preliminary learning from the partnership initiative Up for Arts. While no literature met the inclusion criteria, results indicate that promoting creative engagement for healthy aging could lead to improved public health outcomes. Public Service Local Radio partnership initiatives, such as UfA, may support the development of creative engagement as a positive healthy aging activity, which could be of interest to policymakers seeking novel ways to address health behaviors among older populations.
Article
Allergy
Luciana Kase Tanno, Pascal Demoly
Summary: The International Classification of Diseases (ICD) serves as a common diagnostic and classification tool worldwide, aiming to improve the accuracy of mortality and morbidity statistics for allergic and hypersensitivity conditions. The recent change in hierarchy in ICD-11 has allowed for a dedicated section addressing these conditions, leading to more accurate classification and definitions. The implementation of ICD-11 was adopted at the 72nd World Health Assembly in May 2019.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Ray Wagiu Basrowi, Endang Mariani Rahayu, Levina Chandra Khoe, Erika Wasito, Tonny Sundjaya
Summary: By analyzing the social, nutritional, and health status of the adult population in Indonesia, effective preparations can be made for the future aging population, improving the quality of life.
Book Review
Management
Bilgehan Bozkurt
Summary: The book emphasizes the importance of health and effectiveness for the sustainable development of organizations, and suggests that prioritizing gender equality for women can help organizations stay healthy during the pandemic. Its contribution lies in providing actionable recommendations in times of uncertainty, prioritizing sustainable development goals, and attempting to strengthen the goals that are facing challenges.
Article
Public, Environmental & Occupational Health
Madara Mikelsone, Ieva Reine, Signe Tomsone, Helgi Guomundsson, Andrejs Ivanovs, Halldor S. Guomundsson
Summary: This study developed a comparable Healthy Aging Index (HAI) by using data from the Survey of Health, Aging and Retirement in Europe (SHARE) and a study on the health and wellbeing of older adults in Iceland. The constructed HAI includes four similar subscales-Autonomy, Health, Wellbeing, and Activities for both countries, and an additional subscale Cognitive for Latvia. Matching items were found in all four subscales, making it a useful tool for analyzing long-term changes in aging across societies.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Psychiatry
Christina Mikkelsen, Margit A. H. Larsen, Erik Sorensen, Thomas Folkmann Hansen, Susan Mikkelsen, Christian Erikstrup, Kaspar R. Nielsen, Mie T. Bruun, Henrik Hjalgrim, Lars Kessing, Thomas Werge, Henrik Ullum, Sisse R. Ostrowski, Ole B. Pedersen, Lise W. Thorner, Maria Didriksen
Summary: This study investigated the point prevalence of Major Depressive Disorder (MDD) and sex differences in symptomatology among undiagnosed, healthy adults. It also explored whether specific symptoms increased the likelihood of later needing anti-depressive medication. The results showed that MDD was associated with an increased risk of receiving a prescription for anti-depressive medication in the future, with the risk increasing as the severity of MDD increased. Feeling that life is not worth living was the strongest predictive symptom for women, while trouble sleeping was the strongest for men.
PSYCHIATRY RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Parnian Riaz, Fergus Caskey, Mark McIsaac, Razeen Davids, Htay Htay, Vivekanand Jha, Kailash Jindal, Min Jun, Maryam Khan, Adera Levin, Meaghan Lunney, Ikechi Okpechi, Roberto Pecoits-Filho, Mohamed A. Osman, Tushar Vachharajani, Feng Ye, David Harris, Marcello Tonelli, David Johnson, Aminu Bello
Summary: The study showed that countries with different income levels generally have different numbers of healthcare workers. Nephrologists are the main physicians responsible for providing care to KF patients globally, but low-income countries reported shortages of various healthcare providers.
Article
Public, Environmental & Occupational Health
Erik Timmermans, Irina Motoc, J. Mark Noordzij, Marielle A. Beenackers, Rita Wissa, Aliou Sarr, Asli Gurer, Guillaume Fabre, Milagros Ruiz, Dany Doiron, Joost Oude Groeniger, Dorly Deeg, Frank J. Van Lenthe, Martijn Huisman
Summary: This study examined the associations of objectively measured social and physical neighbourhood characteristics with loneliness in older adults and found no significant evidence of a relationship between the two.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2021)
Review
Environmental Sciences
Christian Brabant, Anton Geerinck, Charlotte Beaudart, Ezio Tirelli, Christophe Geuzaine, Olivier Bruyere
Summary: This study conducted a systematic review and meta-analysis to explore the relationship between childhood leukemia and extremely low frequency magnetic fields (ELF-MF). The results indicate that ELF-MF higher than 0.4 mu T may increase the risk of childhood leukemia, particularly acute lymphoblastic leukemia. Prolonged exposure to electric appliances that generate magnetic fields higher than 0.4 mu T like electric blankets is associated with a greater risk of childhood leukemia.
REVIEWS ON ENVIRONMENTAL HEALTH
(2023)
Review
Medicine, General & Internal
Francesco Di Gennaro, Alessandra Belati, Ottavia Tulone, Lucia Diella, Davide Fiore Bavaro, Roberta Bonica, Vincenzo Genna, Lee Smith, Mike Trott, Olivier Bruyere, Luigi Mirarchi, Claudia Cusumano, Ligia Juliana Dominguez, Annalisa Saracino, Nicola Veronese, Mario Barbagallo
Summary: This study used a systematic review and meta-analysis of observational studies to determine the incidence of long COVID symptoms. The results showed that patients infected with SARS-CoV-2 may experience long-term COVID symptoms regardless of the severity of the acute illness. There were differences in the prevalence of long COVID symptoms among different genders, age groups, continents, and follow-up lengths.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Review
Medicine, Research & Experimental
Xiao-Xuan Zhao, Wen-Qing Xie, Wen-Feng Xiao, Heng-Zhen Li, Shinen Naranmandakh, Olivier Bruyere, Jean-Yves Reginster, Yu-Sheng Li
Summary: This review discusses the pathogenesis of osteoarthritis (OA) and focuses on the role of perlecan in the development of OA. Perlecan has a protective effect in normal cartilage and is involved in vascular invasion, catabolic and anabolic actions of chondrocytes, and pain sensitization pathways in OA.
Article
Nutrition & Dietetics
Vanesa Davalos-Yerovi, Maria Jose Perez-Saez, Anna Faura-Vendrell, Maria Dolors Muns-Cornellas, Xavier Duran, Dolores Sanchez-Rodriguez, Julio Pascual, Ester Marco, FRAILMar Study Grp
Summary: The study aimed to evaluate the value of the Global Leadership Initiative for Malnutrition (GLIM) criteria in predicting hospitalizations and mortality in kidney transplant candidates during their first year on the waiting list. The results showed that malnutrition according to the GLIM criteria was prevalent in patients with chronic kidney disease (CKD) and was associated with a threefold increased risk of hospitalizations during the first year on the waiting list.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Rebecca J. Moon, Jean-Yves Reginster, Nasser M. Al-Daghri, Jotheeswaran A. Thiyagarajan, Charlotte Beaudart, Olivier Bruyere, Nansa Burlet, Manju Chandran, Mario Coelho da Silva, Philip G. Conaghan, Willard H. Dere, Adolfo Diez-Perez, Peyman Hadji, Philippe Halbout, Mickael Hiligsmann, John A. Kanis, Eugene V. McCloskey, Sif Ormarsdottir, Daniel Prieto-Alhambra, Regis P. Radermecker, Rene Rizzoli, Yousef Al-Saleh, Stuart L. Silverman, Lee S. Simon, Friederike Thomasius, Tjeerd van Staa, Andrea Laslop, Cyrus Cooper, Nicholas C. Harvey
Summary: This narrative review summarises the recommendations of a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO) for real-world evidence studies in osteoporosis research. The review emphasizes the importance of conducting research using real-world data to the highest standards and ensuring transparency throughout the study process.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Infectious Diseases
Alexis Messina, Michael Schyns, Bjoern-Olav Dozo, Vincent Denoel, Romain Van Hulle, Anne-Marie Etienne, Stephanie Delroisse, Olivier Bruyere, Vincent D'Orio, Sebastien Fontaine, Michele Guillaume, Anne-Catherine Lange, Gilles Louppe, Fabienne Michel, Anne-Sophie Nyssen, Fabrice Bureau, Eric Haubruge, Anne-Francoise Donneau, Laurent Gillet, Claude Saegerman
Summary: The University of Liege in Belgium commissioned the creation of a serious game called SARS Wars to raise awareness of preventive measures among its university community. After almost two years of design, the game was created as a decision-making management game for browsers and smartphones. The game integrates an adapted SEIR model and allows a better understanding of pandemics and epidemics.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Nutrition & Dietetics
Elena Munoz-Redondo, Andrea Morgado-Perez, Maria-Jose Perez-Saez, Anna Faura, Dolores Sanchez-Rodriguez, Marta Tejero-Sanchez, Delky Meza-Valderrama, Maria Dolors Muns, Julio Pascual, Ester Marco
Summary: This study aimed to evaluate the performance of the phase angle (PhA) as a screening tool for malnutrition in patients with advanced chronic kidney disease (CKD) waiting for kidney transplantation (KT). The study found that a PhA threshold of <= 4.85 degrees had a sensitivity of 72.7%, specificity of 65.9%, and positive and negative likelihood ratios of 2.13 and 0.41, respectively. However, when compared to the Global Leadership Initiative for Malnutrition (GLIM) criteria, the PhA <= 4.85 degrees only showed fair validity for detecting malnutrition in this population.
Review
Geriatrics & Gerontology
Konstantinos Prokopidis, Panagiotis Giannos, Jean Yves Reginster, Olivier Bruyere, Mirko Petrovic, Antonio Cherubini, Konstantinos K. Triantafyllidis, Konstantinos S. Kechagias, Yannis Dionyssiotis, Matteo Cesari, Kinda Ibrahim, David Scott, Mario Barbagallo, Nicola Veronese
Summary: Polypharmacy in older adults is associated with negative consequences on muscular function, regardless of medical conditions. This systematic review and meta-analysis found that sarcopenia is significantly associated with a higher prevalence of polypharmacy and increased number of medications. The analysis included 29 studies and showed that individuals with sarcopenia had a higher risk of polypharmacy and used more medications compared to those without sarcopenia. However, variations were observed due to different populations. Future research should investigate the direct contribution of specific medications and the number of medications to the progression of sarcopenia in older adults.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Cell Biology
Clare Tazzeo, Alberto Zucchelli, Davide Liborio Vetrano, Jacopo Demurtas, Lee Smith, Daniel Schoene, Dolores Sanchez-Rodriguez, Graziano Onder, Cafer Balci, Silvia Bonetti, Giulia Grande, Gabriel Torbahn, Nicola Veronese, Alessandra Marengoni
Summary: The study identified several risk factors, such as age, education level, obesity, hypertension, depression, and low physical function, that are consistently associated with an increased risk of developing multiple chronic diseases. However, there is inconsistency in the results for factors like smoking, alcohol consumption, and dietary patterns. The heterogeneity in settings, exposure and outcome, and baseline health of participants hampers robust conclusions.
AGEING RESEARCH REVIEWS
(2023)
Article
Geriatrics & Gerontology
Celine Demonceau, Fanny Buckinx, Jean-Yves Reginster, Olivier Bruyere
Summary: This study investigated the relationships between frailty, nutritional status, muscle strength, and the incidence and severity of Covid-19 in nursing home residents. The results showed that after adjusting for covariates, there was no association between frailty, nutritional status, grip strength, and the incidence and severity of Covid-19.
Review
Geriatrics & Gerontology
Elena Munoz-Redondo, Andrea Morgado-Perez, Maria Jose Perez-Saez, Julio Pascual, Marta Tejero-Sanchez, Yulibeth G. Curbelo, Marc Terradellas-Fernandez, Delky Meza-Valderrama, Olga Vazquez-Ibar, Cedric Annweiler, Dolores Sanchez-Rodriguez, Ester Marco
Summary: This review provides an overview of frailty, including its epidemiology, screening and diagnostic tools, and new perspectives based on global frameworks. Frailty is a significant health challenge worldwide, affecting older adults and those with chronic diseases regardless of age. Although various screening and diagnostic tools exist, none have proven superior in all populations and healthcare settings. Frailty encompasses physical, cognitive, and social components, and the use of validated tools tailored to specific populations and healthcare systems is recommended. Unintentional weight loss is a common criterion for both physical frailty and malnutrition, while sarcopenia shares criteria of low muscle function and physical performance. Intrinsic capacity, a person-centered and public health indicator, focuses on the positive aspects of aging and aims to promote healthier aging in the Decade of Healthy Aging 2020-2030.
Article
Geriatrics & Gerontology
D. Sanchez-Rodriguez, C. Demonceau, O. Bruyere, E. Cavalier, J. -Y. Reginster, C. Beaudart
Summary: This study aimed to assess the ability of intrinsic capacity (IC) to predict mortality risk in community-dwelling older adults, using different diagnostic criteria to define the nutritional domain. The results showed that unsatisfactory IC in the nutritional domain at baseline was strongly associated with a higher mortality risk.
Review
Geriatrics & Gerontology
Nicola Veronese, Germain Honvo, Olivier Bruyere, Rene Rizzoli, Mario Barbagallo, Stefania Maggi, Lee Smith, Shaun Sabico, Nasser Al-Daghri, Cyrus Cooper, Francesco Pegreffi, Jean-Yves Reginster
Summary: This umbrella review examined the association between knee osteoarthritis and adverse health outcomes. The results showed that knee osteoarthritis is significantly associated with cardiovascular mortality, falls, and conditions related to subclinical atherosclerosis. However, the certainty of this evidence is weak.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Fanny Buckinx, Marvin Rezoulat, Esar Lefranc, Jean-Yves Reginster, Olivier Bruyere
Summary: This study demonstrates that remote physical performance measurements of older adults exhibit consistently high levels of relative reliability compared to face-to-face measurements. Additionally, certain remote evaluations show acceptable absolute reliability.
Meeting Abstract
Geriatrics & Gerontology
C. Beaudart, D. Sanchez-Rodriguez, C. Demonceau, E. Cavalier, J. -Y. Reginster, O. Bruyere
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)