Article
Clinical Neurology
Saul A. Frankford, Lena C. O'Flynn, Kristina Simonyan
Summary: This study investigated sensory processing in auditory and olfactory domains in patients with laryngeal dystonia, and found that auditory temporal discrimination and olfactory function are likely not endophenotypic markers of the disorder.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Md Fazley Rabbi Sha, Yuriko Koga, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
Summary: The olfactory tubercle (OT), a component of the olfactory cortex and ventral striatum, plays a role in odor-guided motivated behaviors. Through olfactory experience, the neuronal connectivity within the OT domains can be altered. It was found that attractive learning strengthens connections in the anteromedial (am) domain, while aversive learning strengthens connections in the lateral (l) domain of the OT.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Elisa Galliano, Christiane Hahn, Lorcan P. Browne, Paula R. Villamayor, Candida Tufo, Andres Crespo, Matthew S. Grubb
Summary: Temporary sensory deprivation can induce structural and functional plasticity in dopaminergic neurons in the olfactory bulb, resulting in changes in axon initial segment length and intrinsic excitability. This experience-dependent plasticity may help fine-tune sensory processing in the face of continuously fluctuating inputs.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Thomas Offner, Lukas Weiss, Daniela Daume, Anna Berk, Tim Justin Inderthal, Ivan Manzini, Thomas Hassenkloever
Summary: In this study, the impact of the wiring between olfactory receptor neuron axons and mitral/tufted cell dendrites on glomerular module organization and odor representations in the Xenopus laevis olfactory bulb network was investigated. The results showed that amino acid odorants are not organized in a stereotypic or chemotopic manner on isolated glomeruli. It was concluded that odor map heterogeneity is caused by the coexistence of different intermingled glomerular modules, suggesting that the organization of the amphibian main olfactory system is not strictly based on uni-glomerular connectivity.
Article
Neurosciences
Ethan Schonfeld, Elan Schonfeld, Casey Aman, Navroop Gill, Dami Kim, Sydney Rabin, Bushraa Shamshuddin, Lloyd Sealey, Ricardo Gabriel Senno
Summary: Sensory and olfactory deficits tend to lateralize to the left side of the body, while motor deficits lateralize to the right side. Clinical correlates of motor lateralization include female gender, depression, MMSE<15, and diabetes, while clinical correlates of sensory lateralization include use of psychotherapeutic agent, age, MMSE<15, and male gender. Clinical correlates of olfactory lateralization include age, number of medications, and male gender.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biology
Demian Burguera, Francesco Dionigi, Kristina Kverkova, Sylke Winkler, Thomas Brown, Martin Pippel, Yicheng Zhang, Maxwell Shafer, Annika L. A. Nichols, Eugene Myers, Pavel Nemec, Zuzana Musilova
Summary: We found independent expansions producing large gene repertoires in several lineages of nocturnal amphibious fishes, generally able to perform active terrestrial exploration. Furthermore, we also detected an augmented information-processing capacity in the olfactory bulb of nocturnal amphibious fishes. Overall, we report a convergent genomic and phenotypic magnification of the olfactory system in nocturnal amphibious fishes.
Article
Neurosciences
Bing Han, Shu Kikuta, Teru Kamogashira, Kenji Kondo, Tatsuya Yamasoba
Summary: The circadian system plays a crucial role in regulating sleep/wake cycles and modulating adult neurogenesis. This study investigates the effects of sleep deprivation (SD) on the regeneration of olfactory sensory neurons (OSNs) following injury to the olfactory epithelium (OE). The results demonstrate that SD accompanied by disrupted circadian activity can negatively impact the regeneration of OSNs in the dorsomedial area of the OE, potentially involving the biological activity of NQO1.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Kevin W. Zhu, Shawn D. Burton, Maira H. Nagai, Justin D. Silverman, Claire A. de March, Matt Wachowiak, Hiroaki Matsunami
Summary: This study utilized targeted spatial transcriptomics to map the distribution of olfactory receptors in the murine olfactory bulb and generated a 3D model. The findings revealed a relationship between receptors and odorants, providing significant insights into olfaction.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Alexandra Angelova, Marie-Catherine Tiveron, Mathieu D. Loizeau, Harold Cremer, Jean-Claude Platel
Summary: Neurogenesis continues to occur in the subventricular zone of the brain after birth, producing various types of olfactory bulb (OB) interneurons. In this study, we used genetic labeling and reversible unilateral sensory deprivation to investigate the behavior of postnatally born glomerular neurons. We found that sensory deprivation leads to cell death and changes in neurotransmitter use in specific neuron types, while reopening of the naris reverses these effects.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Shu Kikuta, Bing Han, Tatsuya Yamasoba
Summary: The objective of this study was to determine if olfactory sensory neurons are uniformly damaged in PVOD. Comparing PVOD patients with CRS and PTOD patients, it was found that a response to a single odor is characteristic of PVOD, while there were no significant abnormalities in the response to five different odors. In mouse experiments, it was found that a single odor selectively activated one type of sensory neurons, while five different odors activated both types of sensory neurons simultaneously.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Zhenjie Ma, Weihao Li, Liujing Zhuang, Tieqiao Wen, Ping Wang, Hongmeng Yu, Yongliang Liu, Yiqun Yu
Summary: In this study, TMEM59 is identified as a critical regulator in maintaining and regenerating the olfactory epithelium. TMEM59 deletion leads to transcriptional changes, affecting genes associated with olfactory transduction and inflammatory/immune response. Loss of TMEM59 impairs olfactory functions, decreases proliferation, and promotes infiltration of inflammatory cells. TMEM59 also plays a role in the regeneration of the olfactory epithelium, with reduced proliferative cells and sensory neurons. Anti-inflammatory treatment can recover neuronal generation and olfactory functions, suggesting a potential therapy for olfactory dysfunction associated with inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biology
Kaitlin Ching, Jennifer T. Wang, Tim Stearns, Danelle Devenport
Summary: This study discovered that centrioles migrate together during dendrite outgrowth in olfactory sensory neurons (OSNs) and form cilia during maturation. They are associated with microtubule nucleation factors and the parental centriole forms a cilium before other centrioles.
Review
Psychology, Multidisciplinary
Cecilia Bembibre, Matija Strlic
Summary: Olfactory heritage research is multidisciplinary and plays an important role in understanding the relationship between smells and communities. However, current research is largely limited within disciplinary boundaries, lacking integration of knowledge and methods, as well as interdisciplinary interpretation.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Food Science & Technology
Williara Queiroz de Oliveira, Paulo Henrique Machado De Sousa, Glaucia Maria Pastore
Summary: This article reports that taste and smell disorders resulting from COVID-19 may have an impact on eating pleasure and nutrition. It also highlights important technologies and trends that can be considered and improved in future studies.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Predrag Jovanovic, Celine E. Riera
Summary: Olfactory perception plays a crucial role in daily decision making in mammals, guiding food consumption, social interactions, and predator avoidance. Recent studies have shown that olfaction is involved in regulating energy intake and expenditure through neuronal circuits, and gastrointestinal hormones may also influence olfactory sensitivity and food seeking behaviors. This article reviews the identification of these neuronal networks and discusses how dysregulation of bidirectional neurocircuits between olfactory and energy processing centers may occur during obesity.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)