Article
Oncology
Archya Dasgupta, Benjamin Geraghty, Pejman Jabehdar Maralani, Nauman Malik, Michael Sandhu, Jay Detsky, Chia-Lin Tseng, Hany Soliman, Sten Myrehaug, Zain Husain, James Perry, Angus Lau, Arjun Sahgal, Gregory J. Czarnota
Summary: A radiomic signature was developed to distinguish between areas of microscopic tumors and edema in the PTR of GBM, which correlates with areas of future recurrence.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Zahra Riahi Samani, Drew Parker, Ronald Wolf, Wes Hodges, Steven Brem, Ragini Verma
Summary: This study differentiates primary glioblastomas and brain metastases by training a CNN on the free water volume fraction derived from DTI. The CNN achieved higher accuracy in discriminating metastases, outperforming conventional DTI-based measures. Results demonstrate that the free water volume fraction is best able to characterize peritumoral tissue differences.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Jianhong Cheng, Jin Liu, Hailin Yue, Harrison Bai, Yi Pan, Jianxin Wang
Summary: In this study, a novel radiomics-based pipeline incorporating intratumoral and peritumoral features was proposed to accurately predict glioma grade before surgery. The method achieved high accuracy in predicting glioma grade using multi-parametric MRI scans and outperformed state-of-the-art methods. The proposed method also demonstrated strong generalization performance in an external validation dataset.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2022)
Review
Biochemistry & Molecular Biology
Marianna Makowska, Beata Smolarz, Hanna Romanowicz
Summary: Glioblastoma multiforme (GBM) is a common, malignant brain tumor with a poor prognosis. Traditional treatments have limited success due to the tumor's infiltrating growth and resistance. The search for new therapies is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Benjamin J. Geraghty, Archya Dasgupta, Michael Sandhu, Nauman Malik, Pejman Jabehdar Maralani, Jay Detsky, Chia-Lin Tseng, Hany Soliman, Sten Myrehaug, Zain Husain, James Perry, Angus Lau, Arjun Sahgal, Gregory J. Czarnota
Summary: Quantitative image analysis using postoperative radiation planning MRI-based radiomics can predict the outcomes in patients with glioblastoma. Imaging features extracted from the gross tumor volume and clinical target volume can lead to risk-stratification of glioblastoma undergoing biopsy, while the utility in other individual subgroups needs to be further explored.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Han, Yang Yang, Zhe-sheng Shi, An-ding Zhang, Lin-feng Yan, Yu-chuan Hu, Lan-lan Feng, Jiao Ma, Wen Wang, Guang-bin Cui
Summary: The study successfully differentiated brain inflammation from grade II glioma using radiomics features, showing better diagnostic efficacy compared to experienced radiologists.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Jialiang Wu, Fangrong Liang, Ruili Wei, Shengsheng Lai, Xiaofei Lv, Shiwei Luo, Zhe Wu, Huixian Chen, Wanli Zhang, Xiangling Zeng, Xianghua Ye, Yong Wu, Xinhua Wei, Xinqing Jiang, Xin Zhen, Ruimeng Yang
Summary: This study successfully differentiated glioblastoma multiforme and solitary brain metastasis using radiomics features and machine learning techniques, providing important insights for clinical diagnosis and treatment.
Article
Cell Biology
Yuqi Han, Lingling Zhang, Shuzi Niu, Shuguang Chen, Bo Yang, Hongyan Chen, Fei Zheng, Yuying Zang, Hongbo Zhang, Yu Xin, Xuzhu Chen
Summary: The study aimed to differentiate between cerebral glioblastoma multiforme (GBM) and solitary brain metastasis (MET) using clinical, MRI, and radiomics analyses. Results showed that combining clinical, MRI, and radiomic features was helpful in distinguishing between different diseases, demonstrating the superiority of certain classifiers in this differentiation task.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Liyuan Zhang, Yang Yang, Ting Wang, Xi Chen, Mingyue Tang, Junnan Deng, Zhen Cai, Wei Cui
Summary: This study developed a model based on intratumoral and peritumoral radiomics to predict the histopathological grade of soft tissue sarcoma (STS). The model showed good performance in distinguishing low-grade from high-grade STSs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingtao Wang, Xuejun Zheng, Jinling Zhang, Hao Xue, Lijie Wang, Rui Jing, Shuo Chen, Fengyuan Che, Xueyuan Heng, Gang Li, Fuzhong Xue
Summary: This study developed and validated a radiomics signature for predicting survival and chemotherapeutic benefits of patients with lower-grade gliomas. The radiomics signature showed better prognostic performance than signatures derived from individual sequences.
EUROPEAN RADIOLOGY
(2021)
Review
Oncology
Gianluca Trevisi, Annunziato Mangiola
Summary: In this manuscript, the authors review the biological characteristics of glioblastoma peritumoral tissue and emphasize its importance in glioblastoma progression and recurrence. The peritumoral brain zone (PBZ) is the primary target for post-operative adjuvant treatment, and understanding its unique microenvironment and cellular landscape is crucial for developing more effective treatments.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Qiu, Yun-Fan Liu, Xin Shu, Xiao-Feng Qiao, Guang-Yong Ai, Xiao-Jing He
Summary: This study developed and evaluated a machine learning model based on peritumoral radiomic features to differentiate low-Gleason grade group (L-GGG) and high-GGG (H-GGG) prostate lesions. The model showed superior performance compared to the original tumor and centra-tumoral classification models.
ACADEMIC RADIOLOGY
(2023)
Review
Immunology
Boyuan Huang, Xuesong Li, Yuntao Li, Jin Zhang, Zhitao Zong, Hongbo Zhang
Summary: Glioblastoma multiforme (GBM) is the most common and aggressive malignant tumor in the central nervous system. Immunotherapy has shown promising results in the treatment of GBM, but future developments will require an integrated approach with various treatment modalities and specific targeted therapies for the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Mathematics, Interdisciplinary Applications
O. Bavi, M. Hosseininia, M. Hajishamsaei, M. H. Heydari
Summary: In this study, a time fractional reaction-diffusion equation based on the moving least squares method was used to predict the growth of the GBM tumor model in the mouse brain. The results showed that the Proliferation-Invasion model implemented in a time fractional form had a better agreement with experimental results, with a prediction error of less than 1%. The presented model also has the potential to consider the effects of therapeutic factors on tumor growth and can be applied in personalized medicine.
CHAOS SOLITONS & FRACTALS
(2023)
Article
Multidisciplinary Sciences
Duyen Thi Do, Ming-Ren Yang, Luu Ho Thanh Lam, Nguyen Quoc Khanh Le, Yu-Wei Wu
Summary: Using a radiomics-based machine learning model, we can predict the O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status in glioblastoma multiforme (GBM) patients preoperatively and noninvasively. The model achieved high accuracy and specificity using a genetic algorithm-based feature selection method, indicating potential wide application in both low- and high-grade gliomas.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
K. Liang Zeng, Ahmed Abugarib, Hany Soliman, Sten Myrehaug, Zain A. Husain, Jay Detsky, Mark Ruschin, Aliaksandr Karotki, Eshetu G. Atenafu, Jeremie Larouche, Mikki Campbell, Pejman Maralani, Arjun Sahgal, Chia-Lin Tseng
Summary: Stereotactic body radiation therapy (SBRT) for spine metastases improves pain response rates compared with conventional external beam radiation therapy. This study investigates the optimal fractionation schedule and reports improved local control with dose-escalated 2-fraction spine SBRT. The results show that a dose of 28 Gy in 2 fractions is associated with better local control without increasing the risk of vertebral compression fracture (VCF).
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hatef Mehrabian, Rachel W. Chan, Arjun Sahgal, Hanbo Chen, Aimee Theriault, Wilfred W. Lam, Sten Myrehaug, Chia-Lin Tseng, Zain Husain, Jay Detsky, Hany Soliman, Greg J. Stanisz
Summary: Saturation transfer MRI methods can be used to distinguish radiation necrosis from tumor progression. The magnetization transfer ratio provides the largest effect sizes among all metrics.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Letter
Hematology
Bhausaheb Bagal, Rup Sarma, Sayak Dey, Lingaraj Nayak, Avinash Bonda, Jayant Goda, Nehal Khanna, Archya Dasgupta, Sangeeta Kakoti, Abhishek Chatarjee, Hasmukh Jain, Sridhar Epari, Siddhartha Laskar, Manju Sengar, Tejpal Gupta
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Michael Yan, Minha Lee, Sten Myrehaug, Chia-Lin Tseng, Jay Detsky, Hanbo Chen, Sunit Das, Collins Yeboah, Nir Lipsman, Leodante Da Costa, Lori Holden, Chinthaka Heyn, Pejman Maralani, Mark Ruschin, Arjun Sahgal, Hany Soliman
Summary: This study aimed to report the outcomes of salvage hypofractionated stereotactic radiosurgery (HSRS) for brain metastases that failed prior HSRS/SRS. The results showed that HSRS can effectively control local failures and has low toxicity rates.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Jeevi Mona Priyadharshni Selvarajan, Sridhar Epari, Arpita Sahu, Archya Dasgupta, Abhishek Chatterjee, Tejpal Gupta
Summary: Primary diffuse leptomeningeal melanocytosis (PDLM) is a rare CNS tumor that presents diagnostic and therapeutic challenges due to its overlapping features with aseptic meningitis. This case report describes a patient initially treated for viral meningitis based on MRI and CSF analysis, but later diagnosed with PDLM through meningeal biopsy. The patient underwent ventriculoperitoneal shunt and craniospinal irradiation, and remains stable on regular surveillance. Optimal management of PDLM is controversial, with the role of radiotherapy, chemotherapy, targeted therapy, and immunotherapy still being debated.
Article
Health Care Sciences & Services
Debanjali Datta, Archya Dasgupta, Abhishek Chatterjee, Arpita Sahu, Kajari Bhattacharya, Lilawati Meena, Kishore Joshi, Ameya Puranik, Indraja Dev, Aliasgar Moiyadi, Prakash Shetty, Vikas Singh, Vijay Patil, Nandini Menon, Sridhar Epari, Ayushi Sahay, Tejpal Gupta
Summary: Re-irradiation (ReRT) is an effective treatment for recurrent/ progressive high-grade glioma (HGG). This study investigated the recurrence patterns following ReRT and found that local recurrence is most common within the high-dose region.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Neuroimaging
Swetha M. Nair, Arpita Sahu, Archya Dasgupta, Ameya Puranik, Tejpal Gupta
Summary: After completing adjuvant radiation and chemotherapy, imaging surveillance plays a crucial role in managing diffuse gliomas. The primary purpose of imaging is to identify recurrences earlier than clinical symptoms. Magnetic resonance imaging (MRI) is considered the preferred follow-up protocol due to its better soft tissue visualization and multiparametric nature. Differentiating between true recurrence and treatment-related changes is essential as their clinical courses differ. Additional functional imaging modalities can provide further information on the microenvironment. In equivocal cases, follow-up imaging at shorter intervals may be needed to resolve the diagnostic dilemma. This case report describes a patient with recurrent oligodendroglioma who presented with seizures five years after completing chemotherapy for recurrence. MRI revealed subtle new gyral thickening in the left frontal region, along with mild perfusion increase and patchy areas of raised choline. FET-PET showed an increased tumor-to-white matter ratio, supporting tumor recurrence. A short interval follow-up MRI performed two months later showed a decrease in gyral thickening and resolution of enhancing areas in the left frontal lobe. Repeat imaging one year later demonstrated stable disease status without new findings. Based on the resolution of changes without anti-tumor intervention, the authors conclude this to be peri-ictal pseudoprogression, the second reported case in India.
NEURORADIOLOGY JOURNAL
(2023)
Review
Oncology
Tejas Kapadia, Arpita Sahu, Abhishek Mahajan, Ankita Ahuja, Abhishek Chatterjee, Amit Sahu, Anshu Warade, Shubham Padashetty, Antariksh Vijan, Natesan Chidambaranthan, Archya Dasgupta, Epari Sridhar, Ayushi Sahay, Prakash Shetty, Maya Prasad, Girish Chinnaswamy, Aliasgar Moiyadi, Tejpal Gupta, Foram Gala, Shilpa Sankhe
Summary: Central nervous system (CNS) tumors are the second most common cause of cancer in children, accounting for 20.1% of cancer burden. The most common pediatric brain tumors are astrocytoma and medulloblastoma, with slightly higher incidence of craniopharyngioma in Indian children compared to western high-income countries.
INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY
(2023)
Article
Oncology
James Stewart, Arjun Sahgal, Mahtab M. Zadeh, Bahareh Moazen, Pejman Jabehdar Maralani, Stephen Breen, Angus Lau, Shawn Binda, Brian Keller, Zain Husain, Sten Myrehaug, Jay Detsky, Hany Soliman, Chia-Lin Tseng, Mark Ruschin
Summary: Magnetic resonance image-guided radiotherapy for intracranial indications is a promising advance, but uncertainties remain for both target localization after translation-only MR setup and intrafraction motion. This investigation quantified these uncertainties and developed a population-based PTV model to explore target and OAR volumetric coverage tradeoffs.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Clinical Neurology
Chris Heyn, Alan R. Moody, Chia-Lin Tseng, Erin Wong, Tony Kang, Anish Kapadia, Peter Howard, Pejman Maralani, Sean Symons, Maged Goubran, Anne Martel, Hanbo Chen, Sten Myrehaug, Jay Detsky, Arjun Sahgal, Hany Soliman
Summary: This study demonstrates the accurate and reproducible segmentation of brain metastases using a semi-automated algorithm called BLAST. The results show that BLAST has potential as a tool for radiation planning and evaluating treatment response.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Oncology
Y. Baviskar, B. Likonda, S. Pant, S. Mokal, A. Pawar, A. Dasgupta, A. Chatterjee, T. Gupta
Summary: Longitudinal quality of life (QoL) outcomes and survival in patients with poor-prognosis high-grade glioma (HGG) treated with palliative hypofractionated radiotherapy were reported. Short-course palliative hypofractionated radiotherapy was associated with stable and/or improved QoL scores in several domains.
Article
Respiratory System
Chin Heng Fong, Nicholas Meti, Timothy Kruser, Jessica Weiss, Zhihui Amy Liu, Hirokazu Takami, Yoshitaka Narita, Fabio Ynoe de Moraes, Archya Dasgupta, Choo Khoon Ong, James C. H. Yang, Jih Hsiang Lee, Natalya Kosyak, Nicholas Pavlakis, Paul Kongkham, Mark Doherty, Natasha B. Leighl, David B. Shultz
Summary: International survey found significant variation in recommendations for the management of brain metastases in EGFRm or ALK+ NSCLC patients among medical, clinical, and radiation oncologists, as well as neurosurgeons. Development of multidisciplinary guidelines and further research on establishing optimal treatment strategies is warranted.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Oncology
Wee Loon Ong, Melanie Davidson, Patrick Cheung, Hans Chung, William Chu, Jay Detsky, Stanley Liu, Gerard Morton, Ewa Szumacher, Chia-Lin Tseng, Danny Vesprini, Ananth Ravi, Merrylee Mcguffin, Liying Zhang, Alexandre Mamedov, Andrea Deabreu, Meghan Kulasingham-Poon, Andrew Loblaw
Summary: This study aimed to correlate dosimetric parameters with toxicities and quality of life outcomes in two-fraction prostate stereotactic ablative radiotherapy (SABR). The results showed that dose parameters of the bladder and penile bulb were associated with toxicities, highlighting the importance of dose constraints in mitigating treatment-related side effects.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Archya Dasgupta, Murtuza Saifuddin, Evan Mcnabb, Ling Ho, Lin Lu, Danny Vesprini, Irene Karam, Hany Soliman, Edward Chow, Sonal Gandhi, Maureen Trudeau, William Tran, Belinda Curpen, Greg Stanisz, Arjun Sahgal, Michael Kolios, Gregory J. Czarnota
Summary: Preclinical studies have shown that focused ultrasound stimulated microbubble rupture can activate the acid sphingomyelinase-ceramide pathway in endothelial cells. When delivered concurrently with radiotherapy, it leads to increased cell death and strong radiosensitization. This is the first human trial of using magnetic resonance imaging guided focused ultrasound microbubble treatment for breast malignancies.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Tejpal Gupta, Jeevi Mona Priyadharshni Selvarajan, Sadhana Kannan, Nandini Menon, Archya Dasgupta, Abhishek Chatterjee
Summary: This article reviews the efficacy of extended adjuvant temozolomide (TMZ) compared to standard adjuvant TMZ in newly diagnosed glioblastoma patients, based on nonrandomized studies and randomized controlled trials (RCTs). The results show that extended adjuvant TMZ is associated with a significant reduction in the risk of progression and death compared to standard adjuvant TMZ. However, the survival benefit of extended adjuvant TMZ is mainly driven by nonrandomized studies and is not observed when only data from RCTs are considered.
NEURO-ONCOLOGY ADVANCES
(2023)