Review
Oncology
Huikai Zhang, Fanen Yuan, Yangzhi Qi, Baohui Liu, Qianxue Chen
Summary: Liquid biopsy has been applied in various cancers but little progress has been made in validating circulating biomarkers for brain malignancies. Data on circulating tumor cells in glioma are limited, and their application as a biomarker has just begun.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Douglas Guedes de Castro, Antonio Cassio Assis Pellizzon, Alexcia Camila Braun, Michael Jenwei Chen, Maria Leticia Gobo Silva, Ricardo Cesar Fogaroli, Guilherme Rocha Melo Gondim, Henderson Ramos, Elson Santos Neto, Carolina Humeres Abrahao, Liao Shin Yu, Emne Ali Abdallah, Vinicius Fernando Calsavara, Ludmilla Thome Domingos Chinen
Summary: The expression of HER2 in circulating tumor cells (CTC) of breast cancer brain metastases (BCBM) patients is associated with longer distant brain failure-free survival, suggesting its potential for treatment selection.
Article
Oncology
Nayan Lamba, Patrick Y. Wen, Ayal A. Aizer
Summary: Brain metastases significantly impact patients with advanced extracranial malignancies, but their incidence remains poorly described. Recent studies have shown the viability of using claims data for epidemiologic investigations of brain metastases.
Review
Genetics & Heredity
Jialing Liu, Jingru Lian, Yafei Chen, Xin Zhao, ChangZheng Du, Yang Xu, Hailiang Hu, Hai Rao, Xin Hong
Summary: Late-stage cancer metastasis is incurable in the clinic and is the leading cause of death in patients. Circulating tumor cells (CTCs), considered to be metastatic precursors shed from primary tumors, present challenges in isolation and characterization. Despite these difficulties, recent advancements in CTC isolation and culture techniques show promise for potential use as non-invasive biomarkers in predicting therapeutic response.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Jie Zhang, Yang Hong, Liang Wang, Weiheng Hu, Guangming Tian, Di Wu, Yang Wang, Ling Dai, Ziran Zhang, Yue Yang, Jian Fang
Summary: This study aimed to detect and describe the distribution characteristics of circulating tumor cells (CTCs) and circulating tumor-derived endothelial cells (CTECs) in patients with advanced lung cancer, and explore the correlation between CTC/CTEC subtypes and novel prognostic biomarkers. CTCs and CTECs derived from 52 patients with advanced lung cancer were identified using the subtraction enrichment-immunofluorescence in situ hybridization (SE-iFISH) system.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Da Hyun Lee, Ji Eun Park, NakYoung Kim, Seo Young Park, Young-Hoon Kim, Young Hyun Cho, Ho Sung Kim
Summary: The study showed that solid low-enhancing and nonviable tissue habitats on structural MRI can help localize viable tumors in patients with brain metastases after SRS. Physiologic MRI habitats were not indicative of viable tumors. These findings suggest that structural MRI may be more useful in distinguishing viable tumor from radiation necrosis.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Thomas Pierret, Niccolo Giaj-Levra, Anne-Claire Toffart, Filippo Alongi, Denis Moro-Sibilot, Elisa Gobbini
Summary: Immunotherapy is an important treatment strategy for NSCLC patients, including those with brain metastases and meningeal involvement, but further research is needed due to limited data on the efficacy in these specific patient populations.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Rimas V. Lukas, Jigisha P. Thakkar, Massimo Cristofanilli, Sunandana Chandra, Jeffrey A. Sosman, Jyoti D. Patel, Priya Kumthekar, Roger Stupp, Maciej S. Lesniak
Summary: This article reviews the current diagnostic and therapeutic management of Leptomeningeal metastases (LM) from solid tumors. Different therapeutic modalities are discussed, and future directions for research, particularly the role of cerebrospinal fluid circulating tumor cells and cell free circulating tumor DNA in diagnosis and response assessment, are highlighted.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wojciech Jelski, Barbara Mroczko
Summary: Brain tumors are often diagnosed too late for successful therapy, requiring minimally invasive methods for diagnosis and monitoring; liquid biopsies are gaining interest as substitutes for tumor tissue in diagnosing and monitoring brain tumors; current available markers have significant limitations, and conflicting reports may stem from a lack of complete understanding of these markers despite extensive research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medical Laboratory Technology
Amelie Darlix, Laure Cayrefourcq, Stephane Pouderoux, Nicolas Menjot de Champfleur, Alexis Bievelez, William Jacot, Cristina Leaha, Simon Thezenas, Catherine Alix-Panabieres
Summary: The clinical sensitivity of CTC detection in CSF with the CellSearch (R) system for LM diagnosis is higher than that of CSF cytology.
CLINICAL CHEMISTRY
(2022)
Review
Clinical Neurology
Jessica A. Wilcox, Min Jun Li, Adrienne A. Boire
Summary: Leptomeningeal metastases, which can cause significant neurological damage and death, remains a challenging disease to treat. However, there is hope as several studies and clinical trials have shown that certain cancer-directed strategies are effective in improving survival rates for patients with this condition. Further clinical trials are needed to establish the efficacy of treatments and to explore new avenues of treatment.
Article
Oncology
Michael S. Parappilly, Yuki Chin, Riley M. Whalen, Ashley N. Anderson, Trinity S. Robinson, Luke Strgar, Thomas L. Sutton, Patrick Conley, Christopher Klocke, Summer L. Gibbs, Young Hwan Chang, Guanming Wu, Melissa H. Wong, Alison H. Skalet
Summary: This study discovered a new population of tumor cells, called circulating hybrid cells, in the blood of uveal melanoma patients. The number of circulating hybrid cells at the time of initial treatment predicts the future development of disease spread. These cells have the potential to be used as a non-invasive and repeatable liquid biopsy for uveal melanoma patients.
Article
Medicine, General & Internal
Chengjun Zhu, Jing Xu, Jinyu Sun, Shiyun Cui, Yue Sun, Tao Yu, Cenzhu Wang, Tianyao Wang, Yufeng Wu, Feng Ju, Jiafeng Yao, Kai Liu, Wenwen Zhang, Xiaoxiang Guan
Summary: This study investigates the association between circulating tumor cells (CTCs) and breast cancer metastasis. The results show that CTC enumeration is significantly associated with liver metastasis in breast cancer patients, and CTCs >= 5 are a risk factor for tumor metastasis. Furthermore, high CTC levels may be associated with an increased risk of liver metastasis in patients with metastatic breast cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Minsoo Khang, Ranjit S. Bindra, W. Mark Saltzman
Summary: Intrathecal delivery has been clinically used for anesthesia and pain relief, and it also shows potential in treating certain cancers. However, the dynamics and clearance pathways of cerebrospinal fluid pose challenges for predicting drug distribution, and new approaches are needed to overcome these obstacles.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Cell Biology
Mahsa Salehi, Zohre Miri Lavasani, Hani Keshavarz Alikhani, Bahare Shokouhian, Moustapha Hassan, Mustapha Najimi, Massoud Vosough
Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), has become a leading cause of cancer-related deaths worldwide due to late diagnosis and limited therapeutic options. The use of circulating tumor cells (CTCs) holds promise for early detection, accurate prognosis, and monitoring of therapeutic responses in HCC patients. This review discusses the novel materials and technologies used for the isolation and detection of CTCs in HCC, as well as the clinical value of CTC detection.
Article
Neurosciences
U. Shivraj Sohur, Hari K. Padmanabhan, Ivan S. Kotchetkov, Joao R. L. Menezes, Jeffrey D. Macklis
Review
Clinical Neurology
Brian Y. Hwang, Geoffrey Appelboom, Amit Ayer, Christopher P. Kellner, Ivan S. Kotchetkov, Paul R. Gigante, Raqeeb Haque, Michael Kellner, E. Sander Connolly
CEREBROVASCULAR DISEASES
(2011)
Article
Clinical Neurology
Paul R. Gigante, Ivan S. Kotchetkov, Christopher P. Kellner, Raqeeb Haque, Andrew F. Ducruet, Brian Y. Hwang, Robert A. Solomon, Eric J. Heyer, E. Sander Connolly
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2011)
Article
Clinical Neurology
Bartosz T. Grobelny, Andrew F. Ducruet, Peter A. DeRosa, Ivan S. Kotchetkov, Brad E. Zacharia, Zachary L. Hickman, Luis Fernandez, Reshma Narula, Jan Claassen, Kiwon Lee, Neera Badjatia, Stephan A. Mayer, E. Sander Connolly
JOURNAL OF NEUROSURGERY
(2011)
Article
Clinical Neurology
Richard C. E. Anderson, Michael M. McDowell, Christopher P. Kellner, Geoffrey Appelboom, Samuel S. Bruce, Ivan S. Kotchetkov, Raqeeb Haque, Neil A. Feldstein, E. Sander Connolly, Rober T. A. Solomon, Philip M. Meyers, Sean D. Lavine
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2012)
Article
Clinical Neurology
Robert M. Starke, Ricardo J. Komotar, Brian Y. Hwang, Fred Rincon, Ivan S. Kotchetkov, Stephan A. Mayer, E. Sander Connolly
Article
Oncology
Hernando Lopez-Bertoni, Ivan S. Kotchetkov, Nicole Mihelson, Bachchu Lal, Yuan Rui, Heather Ames, Maria Lugo-Fagundo, Hugo Guerrero-Cazares, Alfredo Quinones-Hinojosa, Jordan J. Green, John Laterra
Review
Dentistry, Oral Surgery & Medicine
Brin Freund, Ivan S. Kotchetkov, Aruna Rao
JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE
(2020)
Article
Clinical Neurology
Ivan S. Kotchetkov, Brin Freund, Khalil Husari, Peter W. Kaplan
Summary: This study investigates the role of white matter disease (WMD) in the generation of triphasic waves (TWs) when other common causes are absent. It suggests that less recognized risk factors of WMD and mild metabolic or infectious abnormalities may be drivers of TWs. With the increasing elderly population, treating physicians need to consider factors beyond the common causes of TWs to effectively manage these patients.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Maria Diaz, Jasmin Jo, Mark Smolkin, Sarah Jane Ratcliffe, David Schiff
Summary: The study found that patients with lower-grade gliomas have a higher VTE risk, which is decreased in the presence of an IDH mutation. The incidence of VTE in glioblastoma patients is not affected by MGMT promoter methylation status.
Review
Clinical Neurology
Brin Freund, Ivan S. Kotchetkov, Peter W. Kaplan
Summary: Triphasic waves are commonly seen EEG patterns in patients with acute encephalopathy and are important for diagnosis and prognosis. Although the metabolic disturbances underlying their occurrence have been described, the neuroimaging characteristics are not well defined. Small studies have outlined the common neuroimaging findings in these patients, with subcortical white matter disease potentially being a risk factor for triphasic waves.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Oncology
Laura Liberman, Priya Singh, Kay See Tan, Ruth Gotian
Summary: To promote diversity in cancer research, the SCORE Program at Memorial Sloan Kettering engages undergraduate and post-baccalaureate students from diverse backgrounds in an 8-week summer research program. Demographics and career paths of SCORE students from 2010-2019 were analyzed, revealing high persistence in STEMM careers and increased participation in cancer research. The program successfully attracts and encourages underrepresented students to pursue careers in cancer research.
JOURNAL OF CANCER EDUCATION
(2023)