期刊
JOURNAL OF MOLECULAR NEUROSCIENCE
卷 72, 期 2, 页码 372-381出版社
SPRINGERNATURE
DOI: 10.1007/s12031-021-01959-8
关键词
Autism; Fecal transplant; Bifidobacteria; Cytokines; Hormones; Gut microbiota
资金
- Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University [RGP-1441-0027]
Gut microbiota plays a significant role in neurological disorders, including autism, and modulation of the gut microbiota through fecal microbiota transplantation or probiotic administration could alleviate autistic symptoms and have positive effects on the brain.
Gut microbiota plays a major role in neurological disorders, including autism. Modulation of the gut microbiota through fecal microbiota transplantation (FMT) or probiotic administration, such as Bifidobacteria, is suggested to alleviate autistic symptoms; however, their effects on the brain are not fully examined. We tested both approaches in a propionic acid (PPA) rodent model of autism as treatment strategies. Autism was induced in Sprague-Dawley rats by administering PPA orally (250 mg/kg) for 3 days. Animals were later treated with either saline, FMT, or Bifidobacteria for 22 days. Control animals were treated with saline throughout the study. Social behavior and selected brain biochemical markers related to stress hormones, inflammation, and oxidative stress were assessed. PPA treatment induced social impairments, which was rescued by the treatments. In the brain, Bifidobacteria treatment increased oxytocin relative to control and PPA groups. Moreover, Bifidobacteria treatment rescued the PPA-induced increase in IFN-gamma levels. Both treatments increased GST levels, which was diminished by the PPA treatment. These findings indicate the potential of gut microbiota-targeted therapeutics in ameliorating behavioral deficit and underlying neural biochemistry.
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