Article
Biochemistry & Molecular Biology
Adel Ali Alhowyan, Mohd Abul Kalam, Muzaffar Iqbal, Mohammad Raish, Ahmed M. El-Toni, Musaed Alkholief, Aliyah A. Almomen, Aws Alshamsan
Summary: This study developed amino-functionalized silica nanoparticles (AMSN) and O-Carboxymethyl chitosan-coated AMSN (AMSN-CMC) for ocular delivery of 5-Fluorouracil (5-FU). The optimal formulation of AMSN-CMC-FU showed improved corneal permeation and higher bioavailability compared to 5-FU gel. AMSN-CMC-FU gel was minimally irritating to rabbit eyes, suggesting its potential as a topical formulation for ocular cancer treatment.
Article
Chemistry, Physical
Md Aquib, Hang Zhang, Faisal Raza, Parikshit Banerjee, Rohit Bavi, Samuel Kesse, Kofi Oti Boakye-Yiadom, Mensura Sied Filli, Muhammad Asim Farooq, Bo Wang
Summary: Aminated mesoporous silica nanoparticles (AMPSNPs) were developed as a nanocarrier for disulfiram (DSF) delivery in cancer therapies. The optimized AMPSNPs showed excellent properties and compatibility, providing potential for effective drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biophysics
Dachao Zhang, Fangyuan Jiang, Junhong Ling, Xiao-kun Ouyang, Yang-Guang Wang
Summary: This study successfully used xanthan gum as a stabilizer to improve the stability of zein nanoparticles. The addition of xanthan gum led to the formation of spherical nanoparticles with small particle size and negative zeta potential, which remained stable under various pH, temperature, and salt conditions. Additionally, the composite nanoparticles showed improved encapsulation efficiency and sustained release, making them suitable for delivering bioactive compounds in food and pharmaceutical preparations.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Ting Chen, Bo Zhuang, Yueqi Huang, Yan Liu, Bochuan Yuan, Wanmei Wang, Tianyu Yuan, Lina Du, Yiguang Jin
Summary: This study investigated the prevention and treatment of radiation pneumonitis (RP) using curcumin-loaded nanoparticles. The results showed that the nanoparticles protected cells from radiation injury, reduced inflammation, and alleviated lung tissue damages by scavenging free radicals and possessing antioxidant activity.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Biochemistry & Molecular Biology
Ying Kuang, Junjun Zhai, Qinjian Xiao, Si Zhao, Cao Li
Summary: Mesoporous silica nanoparticles (MSNs) play a significant role in drug delivery systems, and natural polysaccharides are widely used as gate materials, providing good biocompatibility and important biological functions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Khaled AbouAitah, Ahmed A. F. Soliman, Anna Swiderska-Sroda, Amr Nassrallah, Julita Smalc-Koziorowska, Stanislaw Gierlotka, Witold Lojkowski
Summary: Combining natural agents curcumin and colchicine with nanoparticles can enhance anticancer effects, especially against colon cancer cells, showing superior efficacy compared to single delivery.
Article
Pharmacology & Pharmacy
Sepanta Hosseinpour, Maria Natividad Gomez-Cerezo, Yuxue Cao, Chang Lei, Huan Dai, Laurence J. Walsh, Saso Ivanovski, Chun Xu
Summary: This study compared the capacity of mesoporous bioactive glass nanoparticles and mesoporous silica nanoparticles to deliver miRNA to bone marrow mesenchymal stem cells, demonstrating that mesoporous bioactive glass nanoparticles had a stronger osteogenic effect.
Article
Pharmacology & Pharmacy
Chennan Liu, Fangyuan Jiang, Zifeng Xing, Lihong Fan, Yuan Li, Shaoning Wang, Junhong Ling, Xiao-Kun Ouyang
Summary: In this study, we successfully synthesized a novel nanoparticle MSN-NH2-AOS for the delivery of the fat-soluble drug curcumin. The optimized preparation process resulted in high drug encapsulation efficiency and tumor cell targeting of the nanoparticles, which showed strong cytotoxicity against tumor cells.
Article
Pharmacology & Pharmacy
Madhappan Santhamoorthy, Vanaraj Ramkumar, Kokila Thirupathi, Lalitha Gnanasekaran, Vanitha Karuppannan, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: In this study, L-lysine modified mesoporous silica nanoparticles (MS@Lys NPs) were synthesized for the delivery of the anticancer drug curcumin (Cur) to cancer cells. The functionalization of L-lysine groups onto the mesopore channel surfaces of MS@GPTS NPs was achieved through a ring-opening reaction. The structural properties of MS@Lys NPs were examined using various instrumental techniques. The drug loading and pH-responsive drug delivery behavior of MS@Lys NPs were investigated using curcumin as a model drug, and their cytocompatibility and cell uptake behavior were evaluated using MDA-MB-231 cells. The results suggest that MS@Lys NPs have potential for pH-responsive drug delivery in cancer therapy.
Article
Chemistry, Applied
Tzu-Hsuan Lo, Zhi-Yuan Wu, Shiow-Yi Chen, Fan-Yi Meng, Pi-Tai Chou, Chih-Min Wang, Hsiu-Mei Lin
Summary: This study synthesized a temperature-controlled drug carrier with a dual-imaging function loaded with curcumin to inhibit Zika virus infection. By loading the drug into mesoporous silica nanoparticles, the drug's solubility and biocompatibility were improved, allowing for release when body temperature rises. The experiment successfully demonstrated the effectiveness of the temperature-controlled drug carrier with dual-imaging function against Zika virus.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Biophysics
Sharon Rose Pamshong, Dhananjay Bhatane, Santosh Sarnaik, Amit Alexander
Summary: Proteins and peptides (PPs) have advantages as therapeutics, but their effective delivery and bioavailability are challenging due to their large size and susceptibility to environmental conditions. Nanoparticle-based delivery systems, such as mesoporous silica nanoparticles (MSNs), show potential for protecting and delivering PPs to the target site.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Tais de Cassia Ribeiro, Rafael Miguel Sabio, Marcela Tavares Luiz, Lucas Canto de Souza, Bruno Fonseca-Santos, Luis Carlos Cides da Silva, Marcia Carvalho de Abreu Fantini, Cleopatra da Silva Planeta, Marlus Chorilli
Summary: This study investigated the use of curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) and a thermo-responsive hydrogel for the treatment of Alzheimer's disease (AD). The results showed that the MSN-CCM and hydrogel had excellent properties and high permeation values. In vivo studies confirmed the potential of the hydrogel-MSN-CCM formulation in reverting cognitive deficits in an AD model.
Review
Pharmacology & Pharmacy
Maedeh Koohi Moftakhari Esfahani, Seyed Ebrahim Alavi, Peter J. Cabot, Nazrul Islam, Emad L. Izake
Summary: This review discusses the biomedical application of mesoporous silica nanoparticles (MSNs) as drug carriers for cancer therapy. MSNs, with their unique properties, show great potential for improving drug solubility and delivery. The development of multimodal anticancer therapeutics and chemical modifications can further enhance the applications of MSNs. Safety issues related to these nanoparticles are also discussed.
Review
Pharmacology & Pharmacy
Guijin Liu, Dongyu An, Junjian Li, Shiming Deng
Summary: This review summarizes the research progress on zein-based nanoparticles in terms of preparation methods, characteristics, and pharmaceutical applications over the past decade. Zein NPs with different nanostructures can be prepared by chemical crosslinking, desolvation, dispersion, and micromixing. The pharmaceutical applications of zein NPs mainly focus on drug delivery, which can improve drug stability, increase oral bioavailability, control drug release, and enhance drug targeting, effectively improving the pharmaceutical effect. More efforts are needed to analyze the relationship among preparation methods, particle nanostructures, and pharmaceutical properties to promote the scale-up production and clinical application of zein NPs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ivalina Trendafilova, Ralitsa Chimshirova, Denitsa Momekova, Hristo Petkov, Neli Koseva, Penka Petrova, Margarita Popova
Summary: Biologically active substances of natural origin are a promising alternative for treating skin diseases. The limitations of low water solubility and bioavailability in natural compounds can be overcome by developing suitable delivery systems. In this study, a silver-modified mesoporous silica nanocarrier was prepared using the template exchange procedure. The drug-loaded formulation showed high loading efficiency, and the interaction between drugs and carriers was studied. The release experiments demonstrated improved solubility, and the formulations exhibited potent antiradical, antioxidant, and antibacterial activities. The simultaneous delivery of curcumin and capsaicin showed enhanced antiproliferative effects on maligning cells. These findings suggest that the developed delivery systems have promising potential for dermal treatment.
Article
Biotechnology & Applied Microbiology
T. S. Anirudhan, V Manjusha, F. Shainy
Summary: A novel magnetically separable composite material GO-Cys@NiFe2O4@TiO2 was prepared for the effective removal and subsequent photodegradation of the pesticide chlorpyrifos from aqueous solutions. The composite showed excellent stability and regeneration properties, with promising photocatalytic performance under visible light irradiation. The magnetic property of the composite enabled easy separation from the solution, making it economically significant for recyclable and eco-friendly wastewater treatment in the industry.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Biochemistry & Molecular Biology
T. S. Anirudhan, V. Manjusha, V. Chithra Sekhar
Summary: The study prepared a nano cellulose-based drug delivery system for effective delivery of curcumin, showing high drug loading capacity and maximum drug release at specific pH levels. In vitro studies demonstrated cytotoxicity towards cancer cells, and further investigations suggest its potential application for targeted delivery and controlled release of CUR in cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
T. S. Anirudhan, Susan Varghese, V Manjusha
Summary: The study designed and evaluated Hyaluronic Acid coated Pluronic mixed micelles loaded with Paclitaxel and Curcumin for anticancer activity in MCF-7 cells, demonstrating the superior in vitro drug release and anticancer activity of the dual drug-loaded material.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
V. Manjusha, L. R. Reshma, T. S. Anirudhan
Summary: This article introduces a nano-drug delivery system for the treatment of breast cancer, which uses two drug carriers (mesoporous silica nanoparticles and mixed micelles) to design a suitable stimuli-responsive drug delivery system. The system uses paclitaxel loaded mixed micelle as gating agents and doxorubicin loaded mesoporous silica nanoparticles via Schiff base. The gating micelles can achieve drug release under acidic conditions due to the pH-sensitive Schiff base. The system also utilizes the Arginine-glycine-aspartic acid (RGD) peptide to target specific cancer cells. The study results show that this new drug delivery system has potential for targeted delivery and controlled release of doxorubicin and paclitaxel for cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Environmental
M. R. Rajeev, V. Manjusha, T. S. Anirudhan
Summary: In this study, a novel dual drug-loaded carrier was synthesized for transdermal anti-cancer drug delivery. The carrier was characterized and evaluated for its cytotoxicity and drug release profile. The results showed that the synthesized material exhibited good pH-dependent controlled and sustained release of both drugs, with a sustained drug existence in the blood circulation system through the transdermal route of administration.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
V. Manjusha, M. R. Rajeev, T. S. Anirudhan
Summary: Safe delivery of hydrophobic drugs to the tumor site is a challenging task for the scientific community. In this study, iron oxide nanoparticles coated chitosan with [2-(methacryloyloxy) ethyl] trimethyl ammonium chloride (METAC) (CS-IONPs-METAC-PTX) were developed as a drug carrier for hydrophobic drug delivery. The drug carrier exhibited excellent therapeutic efficacy and selectivity when tested in cell lines, demonstrating its potential for PTX delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Reshma Lali Raveendran, Manjusha Valsala, Thayyath Sreenivasan Anirudhan
Summary: Injectable hydrogels with macroscopic ordering, specifically nanosilver embedded Schiff base hydrogel, have been developed for drug delivery, showing excellent biocompatibility and minimal invasiveness. The hydrogel's ordered structure and self-assembled morphology were confirmed using various techniques, and its pH-dependent anticancer activity and antibacterial properties were demonstrated through drug release studies and assays. The hydrogel also exhibited cytotoxicity towards skin cancer cells and can serve as a versatile platform for injectable drug delivery.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Chemistry, Physical
Rajalaxmi Sahoo, C. Reshma, D. S. Shankar Rao, C. V. Yelamaggad, S. Krishna Prasad
Summary: This study investigates the influence of the flexible spacer parity of a guest photoactive liquid crystalline dimer on the photonic bandgap features of the cholesteric and twist grain boundary smectic C phases of the host molecule. The results show that the parity of the photoactive dimer affects the width of the photonic bandgap and the blue-shift of the cholesteric phase. Additionally, the parity of the dimer also affects the layer spacing and two-dimensional periodicity of the liquid crystalline phases.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Sara Rozas, Alberto Gutierrez, Mert Atilhan, Alfredo Bol, Santiago Aparicio
Summary: This study presents a multiscale theoretical investigation on the use of bifunctional hydrophobic Deep Eutectic Solvent for carbon capture using tetrapropylammonium chloride, acetic acid, and ethanolamine. The characterization includes nanoscale analysis of CO2 absorption mechanisms and changes in liquid phase properties during gas capture.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Tabouli Eric Da-yang, Alhadji Malloum, Jean Jules Fifen, Mama Nsangou, Jeanet Conradie
Summary: In this study, the potential energy of different glycine tautomers and their interaction with Cu2+ cations was investigated. The results showed that the solvation medium and the presence of Cu2+ cations influenced the stability of glycine tautomers.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Xiaoliang Gou, Nan Ye, Qingqing Han, Junjie Cui, Long Yi Jin
Summary: In this study, amphiphilic rod-coil molecules with rigid DSA parts and flexible oligoether chains were designed and their assembly capacities were investigated. The morphology of the molecular aggregates was influenced by the pH of the solution and UV light, and the aggregates showed adsorption capacity for nitroaromatic compounds.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Shuang Liu, Liyan Shan, Cong Qi, Wenhui Zhang, Guannan Li, Bei Wang, Wei Wei
Summary: Optimizing the design of styrene-butadiene-styrene copolymer (SBS) is crucial for producing cost-effective SBS modifiers and improving road quality. This study examined the influence of SBS content and molecular structure on viscosity and compatibility. The results showed that the viscosity contribution of SBS is determined by its molecular structure and phase morphology.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Artem A. Petrov, Ekaterina A. Titova, Aydar A. Akhmadiyarov, Ilnaz T. Rakipov, Boris N. Solomonov
Summary: This work focuses on the thermochemistry of solvation of azeotropes. The enthalpies of dissolution of azeotropes in different mediums were determined, and the impact of the structure of the azeotropes on their properties in solution was discussed. A correlation between enthalpies of solvation and molar refraction was used to determine the vaporization enthalpies of azeotropes for the first time. The results were found to be consistent with literature data, obtained using direct and calculated methods. These findings contribute to the analysis of the structure-property relationships of azeotropes.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
L. V. Kamaeva, E. N. Tsiok, N. M. Chtchelkatchev
Summary: Understanding the correlations between liquids and solids allows us to predict the thermodynamic parameter range favorable for the formation of intriguing solid phases by studying liquids. In this study, we experimentally and theoretically investigated an Al-Cu-Co system within different composition ranges, and identified high-temperature solid phases. Our findings demonstrated the correlation between the boundaries of different solid phases and undercooling and viscosity in the concentration area.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
R. Aneesh Kumar, S. Jamelah Al-Otaibi, Y. Sheena Mary, Y. Shyma Mary, Nivedita Acharjee, Renjith Thomas, Renjith Raveendran Pillai, T. L. Leena
Summary: In this study, the interactions between doped and pristine coronenes and adenine nucleobases were investigated using Density Functional Theory. The optimal configurations, adsorption energies, charge transfer, and electrical properties of each complex were calculated. It was found that doped coronene had stronger adsorption strength and charge transfer compared to pristine coronene. The stability of the complexes was attributed to non-covalent interactions in the interactive region. The change in electrical conductivity of coronenes after adsorption suggested their sensitivity towards DNA bases. The predicted energy gap and prolonged recovery time for adenine-coronene configurations indicated the potential application of pristine/doped coronene in DNA detection.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Gang Zhou, Yongwei Liu, Biao Sun, Zengxin Liu, Cuicui Xu, Rulin Liu, Qi Zhang, Yongmei Wang
Summary: The CFD-DEM method was used to simulate the dust deposition pattern in the bronchus of anchor digging drivers, revealing the highest dust concentration in the vortex region of the working face. The study also found a positive correlation between dust particle diameter and bronchial deposition rate, and a negative correlation with alveolar deposition rate.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Yan Zhang, Yafei Luo, Lingkai Tang, Mingyan E, Jianping Hu
Summary: This study investigates the effects of different transition metal decorations on B12N12 nanocages on the adsorption properties of nitrosourea drugs using computational methods. The results reveal the presence of weak non-covalent interactions between metals and nanocages, and the interaction between drugs and nanocages plays a significant role in drug adsorption. Compared to free drugs, the adsorption of drugs on nanocages can facilitate electron transfer, reduce energy gaps and chemical hardness, indicating activity at the target site.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
C. I. Alcolado, J. Poblete, L. Garcia-Rio, E. Jimenez, F. J. Poblete
Summary: In this study, the selective oxidation of aromatic aldehydes was investigated using Ru(VI) as a catalyst and hexacyanoferrate (III) as a cooxidant in an alkaline medium. The reaction mechanism involves complex reaction orders for the oxidant and the aromatic aldehyde, while the reaction order for Ru(VI) is one. The proposed mechanism includes two catalytic cycles and the formation and decomposition of complexes. Quantitative structure-activity relationship analysis showed that deactivating groups in the para-position enhance the process.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Inez A. Barbieri, Marcos L. S. Oliveira, Franciele S. Bruckmann, Theodoro R. Salles, Leonardo Zancanaro, Luis F. O. Silva, Guilherme L. Dotto, Eder C. Lima, Mu. Naushad, Cristiano R. Bohn Rhoden
Summary: This study evaluated the adsorption of zolpidem on magnetic graphene oxide and synthesized magnetic graphene oxide adsorbents for zolpidem removal. The best magnetic nanoadsorbent was found to have a removal percentage of 87.07% at specific pH and temperature conditions. The results suggest that the removal of zolpidem is related to the surface chemistry of the adsorbent rather than the surface area of graphene oxide. The adsorbent showed excellent adsorption efficiency and magnetic behavior, making it a promising material for removing zolpidem from aqueous solutions.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Hongyan Huang, Chunquan Li, Siyuan Huang, Yuling Shang
Summary: This study examines the sensitivity of the thermal conductivity of water-based alumina nanofluids to changes in concentration, sphericity, and temperature. The results show that volume fraction and temperature have a significant impact on the thermal conductivity, while sphericity also needs to be considered. A support vector machine regression model was created to analyze the sensitivity of the thermal conductivity to different parameters. The findings indicate that temperature, sphericity, and volume fraction are the most sensitive variables.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Correction
Chemistry, Physical
V. M. Pergamenshchik, T. Bryk, A. Trokhymchuk
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Valentyn Rudenko, Anatolii Tolochko, Svitlana Bugaychuk, Dmytro Zhulai, Gertruda Klimusheva, Galina Yaremchuk, Tatyana Mirnaya, Yuriy Garbovskiy
Summary: This paper reports on the synthesis, structural characterization, spectral and nonlinear-optical properties of glass nanocomposites made of glass forming ionic liquid crystals and nanoparticles. The study reveals that by exciting the nanocomposites within their absorption band, a control over effective optical nonlinearities can be achieved, allowing the modification of the magnitude and sign of the effective nonlinear absorption coefficient. The proposed strategy using metal-alkanoates based glass-forming ionic liquid crystals and nanoparticles shows great potential for the development of nanophotonics and plasmonics technologies.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
