Silibinin loaded inhalable solid lipid nanoparticles for lung targeting

Aim In the current study, efforts are being made to prepare Inhalable Silibinin loaded solid lipid nanoparticles (SLNs) with narrow size distribution with improved bioavailability. Methods SLNs were formulated by high shear homogenisation method SLNs were characterised, including Differential Scanning Calorimetry (DSC), Fourier transform infra-red spectroscopy (FTIR), particle size analysis, entrapment efficiency with Aerodynamic behaviour. The MTT assay was performed against A549 cell line, to measure their anticancer cell activity with In vivo study. Results Optimized formulation exhibited spherical surface with a mean particle size of 221 +/- 1.251 nm, PI of 0.121 +/- 0.081, zeta potential of -4.12 +/- 0.744. Aerodynamic behaviour such as Mass median aerodynamic diameter (MMAD) and Geometric size distribution (GSD) were found to be 5.487 +/- 0.072 and 2.321 +/- 0.141 respectively proved formulation is suitable for inhalation. In vitro cellular efficacy against A549 cells, revealed that the optimised formulations were more effective and potent. Conclusion The Inhalable SLNs approach was successfully engineered and administered to the lungs safely without causing any problems.

Automated summary

In the current study, inhalable solid lipid nanoparticles loaded with Silibinin were successfully prepared, showing improved bioavailability and higher efficacy against A549 cells. The optimized formulation demonstrated suitable aerodynamic properties for inhalation.