期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 56, 期 3, 页码 835-845出版社
WILEY
DOI: 10.1002/jmri.28086
关键词
gadolinium-based contrast agent; retention; pregnancy; magnetic resonance imaging
资金
- National Natural Science Foundation of China [82071886]
- Scientific Research Foundation for Advanced Talents, Xiang'an Hospital of Xiamen University [PM201809170011]
This study investigated the effects of pregnancy and repeated administration of gadolinium-based contrast agents (GBCAs) on gadolinium (Gd) retention in the brains of mother and pup mice. The results showed that Gd retention after gadoterate meglumine administration was lower than that of gadodiamide and gadopentetate dimeglumine administration in different brain areas of the mother and pup mice, and almost all the detected Gd in pups' brains was intact soluble GBCAs.
Background The association of repeated administration of gadolinium-based contrast agents (GBCAs) with the gadolinium (Gd) retention in the brains of mother and fetus remains unclear. Purpose To investigate the effects of pregnancy and repeated administration of GBCAs on Gd retention in the brains of mother and pup mice. Study type Cross-sectional cohort toxicity study. Animal Model From gestational days 16-19, pregnant (n = 48) BALB/c mice. Field Strength A 9.4 T and fast spin echo sequence. Assessment Half of the mother mice (n = 24) were killed at postnatal day 1 (P1) for inductively coupled plasma mass spectrometry (ICP-MS) and transmission electron microscopy (TEM). Besides the ICP-MS and TEM, four pups were randomly selected from each mother and killed at P1 for ultraperformance liquid chromatography mass spectrometry (UPLC-MS) and Nissl staining. Statistical Tests One-way analysis of variance and unpaired t-test. Results In the group of gadodiamide, retention of Gd in the brains of pregnant mice was significantly lower than that of nonpregnant mice in the area of the deep cerebellar nuclei (DCN) (10.35 +/- 2.16 nmol/g vs. 18.74 +/- 3.65 nmol/g). Retention of Gd in the DCN of pups whose mothers were administered gadoterate meglumine was significantly lower than that of pups whose mothers were administered gadodiamide (0.21 +/- 0.09 nmol/g vs. 6.15 +/- 3.21 nmol/g) at P1. In mice treated with gadodiamide, most of the retained Gd in the brain tissue was insoluble (19.5% +/- 9.5% of the recovered amount corresponded to the intact complex in the DCN). Data Conclusion In different brain areas of the mother and pup mice, the retention of Gd after gadoterate meglumine administration was lower than that of gadodiamide and gadopentetate dimeglumine administration, and almost all the detected Gd in pups' brains was intact soluble GBCAs. Evidence Level 1 Technical Efficacy Stage 2
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