The HDL mimetic CER‐001 remodels plasma lipoproteins and reduces kidney lipid deposits in inherited lecithin:cholesterol acyltransferase deficiency

Administration of the High-Density Lipoprotein Mimetic CER-001 for Inherited Lecithin–Cholesterol Acyltransferase Deficiency

(2021) Stanislas Faguer et al.   ANNALS OF INTERNAL MEDICINE

Genetic, biochemical, and clinical features of LCAT deficiency: update for 2020

(2020) Chiara Pavanello et al.   CURRENT OPINION IN LIPIDOLOGY

Progression of chronic kidney disease in Familial LCAT Deficiency: a follow-up of the Italian cohort

(2020) Chiara Pavanello et al.   JOURNAL OF LIPID RESEARCH

Activation of naturally occurring LCAT mutants by a novel activator compound

(2020) Chiara Pavanello et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

CER-001 ameliorates lipid profile and kidney disease in a mouse model of familial LCAT deficiency

(2020) Alice Ossoli et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The P274S Mutation of Lecithin-Cholesterol Acyltransferase (LCAT) and Its Clinical Manifestations in a Large Kindred

(2019) Nikolaos Fountoulakis et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial

(2018) Stephen J. Nicholls et al.   JAMA Cardiology

Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31

(2017) Lita A. Freeman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement

(2016) Robert D. Shamburek et al.   Journal of Clinical Lipidology

Safety and Tolerability of ACP-501, a Recombinant Human Lecithin:Cholesterol Acyltransferase, in a Phase 1 Single-Dose Escalation StudyNovelty and Significance

(2015) Robert D. Shamburek et al.   CIRCULATION RESEARCH

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

(2015) Ruud S. Kootte et al.   JOURNAL OF LIPID RESEARCH

CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice

(2013) Claudine Tardy et al.   ATHEROSCLEROSIS

Therapeutic management of a new case of LCAT deficiency with a multifactorial long-term approach based on high doses of angiotensin II receptor blockers (ARBs)

(2013) P. Aranda et al.   CLINICAL NEPHROLOGY