期刊
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
卷 64, 期 2, 页码 476-498出版社
WILEY
DOI: 10.1111/jipb.13213
关键词
crop protection; gene expression; RNA silencing; small RNAs; trans-kingdom RNAi
资金
- National Natural Science Foundation of China [32020103003, 31730078, 32170293]
This article reviews the history of RNAi mechanisms, introduces the phenomenon and potential mechanisms of trans-kingdom RNAi, and summarizes the major divergences in RNAi pathways in different kingdoms. It also discusses the applications and critical factors of trans-kingdom RNAi in crop protection.
RNA silencing (or RNA interference, RNAi) is a conserved mechanism for regulating gene expression in eukaryotes. The discovery of natural trans-kingdom RNAi indicated that small RNAs act as signaling molecules and enable communication between organisms in different kingdoms. The phenomenon and potential mechanisms of trans-kingdom RNAi are among the most exciting research topics. To better understand trans-kingdom RNAi, we review the history of the discovery and elucidation of RNAi mechanisms. Based on canonical RNAi mechanisms, we summarize the major points of divergence around RNAi pathways in the main eukaryotes' kingdoms, including plants, animals, and fungi. We review the representative incidents associated with the mechanisms and applications of trans-kingdom RNAi in crop protection, and discuss the critical factors that should be considered to develop successful trans-kingdom RNAi-based crop protection strategies.
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