Article
Pharmacology & Pharmacy
Lian Tang, Xin-yuan Ding, Lu-fen Duan, Lan Li, Hao-di Lu, Feng Zhou, Lu Shi, Jian Lu, Yi Shen, Zhi-wei Zhuang, Jian-tong Sun, Qin Zhou, Chen-qi Zhu, Jing-jing Li, Yan-xia Yu
Summary: In critically ill obstetric patients, Augmented Renal Clearance (ARC) is common and presents unique risk factors and effects on vancomycin (VCM) treatment compared to other populations. The established regression model for predicting ARC showed high predictive value, and the published VCM Population Pharmacokinetic (PPK) models performed well in predicting trough concentrations in obstetric patients. Pharmacokinetic parameters of VCM are altered in ARC obstetric patients, resulting in enhanced drug clearance and decreased trough concentrations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Roland N. Dickerson, Christin N. Crawford, Melissa K. Tsiu, Cara E. Bujanowski, Edward T. Van Matre, Joseph M. Swanson, Dina M. Filiberto, Gayle Minard
Summary: This study aimed to determine the prevalence of augmented renal clearance (ARC) in trauma patients receiving nutrition therapy. Results showed that 50% of patients exhibited ARC, with factors such as male gender, traumatic brain injury, higher injury severity score, younger age, lower serum creatinine concentration, and protein intake being associated with ARC. Patients with multiple risk factors for ARC should be closely monitored for renal dosing of electrolytes, nutrients, and medications.
Review
Pharmacology & Pharmacy
Denise H. Rhoney, Samuel A. Metzger, Nicholas R. Neslon
Summary: This scoping review summarized the evidence on Augmented Renal Clearance (ARC) in pediatric patients, revealing a variable prevalence of ARC in this population likely due to the lack of a standard definition and age-related factors not being consistently considered in studies. ARC was shown to impact the pharmacokinetics of antibiotics commonly used in pediatric patients, potentially requiring adjustments to standard dosing regimens.
Article
Infectious Diseases
David P. Nicolau, Jan De Waele, Joseph L. Kuti, Luzelena Caro, Kajal B. Larson, Brian Yu, Elaine Gadzicki, Zhen Zeng, Elizabeth G. Rhee, Matthew L. Rizk
Summary: This study aimed to determine the adequacy of established ceftolozane/tazobactam dosing for patients with augmented renal clearance (ARC) and bacterial infection. The results showed that a 3 g C/T dose met pharmacodynamic targets for ceftolozane and tazobactam in patients with ARC, with mild to moderate treatment-emergent adverse events observed.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Review
Infectious Diseases
Catarina Mendes Silva, Joao Pedro Baptista, Iolanda Santos, Paulo Martins
Summary: This systematic review searched for recommendations on antibiotic dosage adjustment for critically ill patients with augmented renal clearance (ARC). The findings suggest that increasing dosage and/or adjusting infusion modality are frequently needed to achieve the desired pharmacokinetic/pharmacodynamic (PK/PD) targets.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Julie Gorham, Fabio S. Taccone, Maya Hites
Summary: Obesity is associated with increased risks of comorbidities, postoperative infections, and nosocomial infections. The pharmacokinetics and pharmacodynamics of antibiotics are affected by obesity, leading to increased risks of antibiotic therapy failure and toxicity. Precision dosing of antibiotics using therapeutic drug monitoring may improve the management of critically ill obese patients with infections.
Article
Nutrition & Dietetics
Guilhem Dreydemy, Alexis Coussy, Alexandre Lannou, Laurent Petit, Matthieu Biais, Cedric Carrie
Summary: This pilot study aimed to investigate the association between augmented renal clearance (ARC), urinary nitrogen loss, and muscle wasting in critically ill trauma patients. The findings suggest that patients with ARC have lower nitrogen balance and increased muscle loss in the first 10 days after ICU admission. The benefits of increased protein intake (>1.5 g/kg/day) in these patients are still a matter of controversy and require further randomized trials for confirmation.
Article
Pharmacology & Pharmacy
Idoia Bilbao-Meseguer, Helena Barrasa, Eduardo Asin-Prieto, Ana Alarcia-Lacalle, Alicia Rodriguez-Gascon, Javier Maynar, Jose Angel Sanchez-Izquierdo, Goiatz Balziskueta, Maria Sanchez-Bayton Griffith, Nerea Quilez Trasobares, Maria Angeles Solinis, Arantxa Isla
Summary: This study evaluated the dosing of Levetiracetam in ICU patients with normal or augmented renal clearance (ARC), finding that CrCl influenced the drug clearance rate, with normal renal function patients requiring 500mg/8h or 1000mg/12h, and ARC patients needing higher doses.
Article
Infectious Diseases
Matthias Gijsen, Omar Elkayal, Pieter Annaert, Ruth Van Daele, Philippe Meersseman, Yves Debaveye, Joost Wauters, Erwin Dreesen, Isabel Spriet
Summary: This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of meropenem in critically ill patients with preserved or increased renal function. The results showed poor target attainment, with renal function being the only significant covariate.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Zhenwei Yu, Jieqiong Liu, Haitao Yu, Ling Zhou, Yuhua Zhao, Lin Zhong, Jianping Zhu, Gang Liang, Yi Yang, Ying Zheng, Lingyan Yu, Gang Han
Summary: This multicentre retrospective study explores the conflicts in guideline recommendations about the value and range of vancomycin trough concentration during therapeutic drug monitoring (TDM) for critically ill patients without dialysis. The results suggest that vancomycin trough concentration is a useful marker of AUC for critically ill adults without dialysis. However, AUC-guided TDM may be needed for patients with trough concentrations of 10-15 mg/L, especially for those with risk factors.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Critical Care Medicine
Sujita W. Narayan, Yann Thoma, Philip G. Drennan, Hannah Yejin Kim, Jan-Willem Alffenaar, Sebastiaan Van Hal, Asad E. Patanwala
Summary: This study evaluates the predictive performance of Bayesian models for vancomycin in critically ill patients, finding that while these models exhibit low bias, they also demonstrate low precision, particularly when predicting higher concentrations.
CRITICAL CARE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yidan Wang, Yifan Luo, Shu Yang, Mingyan Jiang, Yang Chu
Summary: Augmented Renal Clearance (ARC) refers to increased renal clearance of solute in critically ill patients. This study utilized transcriptomics and metabolomics analysis to investigate the pathogenesis of ARC at the transcriptional and metabolic levels. Transcriptomics analysis of 534 samples identified 834 differential genes associated with ARC, while metabolomics analysis of 102 samples revealed 45 differential metabolites related to ARC. Combined analysis showed changes in purine metabolism, arginine biosynthesis, and arachidonic acid metabolism in ARC patients. The occurrence of ARC may be attributed to alterations in renal blood perfusion and renal capillary wall permeability mediated by various genes and metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Rekha Pai Mangalore, Aadith Ashok, Sue J. Lee, Lorena Romero, Trisha N. Peel, Andrew A. Udy, Anton Y. Peleg
Summary: This article conducted a systematic review and meta-analysis on the relationship between TDM-guided dosing and clinical outcomes in critically ill patients. The results showed that TDM-guided dosing improved clinical cure, microbiological cure, and treatment response. However, the impact on mortality and length of stay remains unclear and further research is needed.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Immunology
Rekha Pai Mangalore, Aadith Ashok, Sue J. Lee, Lorena Romero, Trisha N. Peel, Andrew A. Udy, Anton Y. Peleg
Summary: TDM-guided dosing of beta-lactam antibiotics improved clinical and microbiological cure in critically ill patients, with no significant impact on mortality and length of stay.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Chailat Maluangnon, Surat Tongyoo, Chairat Permpikul
Summary: This study compared the benefits of continuous and intermittent vancomycin infusion. Continuous infusion was found to achieve therapeutic targets faster and have fewer subtherapeutic episodes compared to intermittent infusion. However, there was no significant difference in treatment success, mortality, or incidence of acute kidney injury between the two methods.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Public, Environmental & Occupational Health
Keisuke Kagami, Nobuhisa Ishiguro, Sumio Iwasaki, Takayuki Usami, Tatsuya Fukumoto, Kasumi Hayasaka, Reiko Oyamada, Tsubasa Watanabe, Sho Nakakubo, Yusuke Niinuma, Takashi Hagino, Yoshifumi Abe, Ikuya Fujimoto, Hideki Maekawa, Ryo Fujibayashi, Satoshi Fuke, Kuniko Asahi, Shuichi Ota, Tatsuya Nagakura, Toshinari Okubo, Hideomi Asanuma, Toshihiro Ito, Sho Okano, Erika Komatsu, Kota Sasaki, Kei Hashimoto, Kazutoshi Washiya, Yumiko Kato, Katsunori Kusumi, Yasufumi Asai, Yuichi Saito, Yoshiyuki Sakai, Minoru Sakurada, Yuji Sakimoto, Yukari Ichikawa, Takahiro Kinebuchi, Dai Kondo, Syuhei Kanno, Minoru Kobayashi, Kagami Hirabayashi, Shinako Saitou, Katsuhiko Saito, Yuuki Ebina, Yuusuke Koshizaki, Makoto Chiba, Atsushi Yasuda, Toshiya Sato, Atsuo Togashi, Takashi Abe, Takahiro Fujita, Kengo Umehara, Masaru Amishima, Nobuo Murakami, Tetsuya Yagi, Shuhei Fujimoto, Taichi Tajima, Mitsuru Sugawara, Yoh Takekuma
Summary: This multicenter study utilized the J-SIPHE system to evaluate the correlation between antibiotic use and antibiotic resistance in Hokkaido, Japan. The results showed a significant positive correlation between the detection rate of carbapenem-resistant Pseudomonas aeruginosa and carbapenem use, as well as between the detection rate of fluoroquinolone-resistant Escherichia coli and the use of piperacillin/tazobactam, carbapenems, and quinolones. This study suggests that using the J-SIPHE system may be beneficial for promoting antimicrobial resistance measures.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Pharmacology & Pharmacy
Yuki Inoue, Yoh Takekuma, Takayuki Miyai, Hitoshi Kashiwagi, Yuki Sato, Mitsuru Sugawara, Shungo Imai
Summary: This study investigated the associated factors and high-risk combinations that influence linezolid-induced thrombocytopenia (LIT) using Japanese big data. Prolonged linezolid therapy, body weight less than 45 kg, estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m(2), and dialysis were identified as risk factors for LIT. The highest risk combination was a combination of prolonged linezolid therapy (>= 14 days) and eGFR less than 30 mL/min/1.73 m(2).
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Oncology
Yoshitaka Saito, Yoh Takekuma, Yoshito Komatsu, Mitsuru Sugawara
Summary: This study retrospectively assessed 100 patients with metastatic colorectal cancer who received regorafenib treatment. The results showed that patients who developed grade 3 or higher hypertension had significantly longer progression-free survival. However, there was no significant difference in overall survival and disease control rate between the groups.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Osamu Taniguchi, Yoshitaka Saito, Yoh Takekuma, Hirotoshi Akita, Ichiro Kinoshita, Yasushi Shimizu, Naofumi Shinagawa, Mitsuru Sugawara
Summary: This study aimed to investigate the effect of antacids on gastrointestinal symptoms caused by cisplatin-containing chemotherapy. The results showed that antacids did not significantly affect the symptoms of anorexia and nausea associated with cisplatin chemotherapy.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Oncology
Yoshitaka Saito, Yoh Takekuma, Takashi Takeshita, Tomohiro Oshino, Mitsuru Sugawara
Summary: This study aimed to investigate whether dexamethasone dosage can prevent taxane-associated acute pain syndrome (T-APS) in breast cancer patients. The results showed that a higher dose of dexamethasone significantly lowered the incidence and severity of T-APS.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Pharmacology & Pharmacy
Yuki Inoue, Yuki Sato, Hitoshi Kashiwagi, Shunsuke Nashimoto, Mitsuru Sugawara, Yoh Takekuma
Summary: This study compared the concentrations of tedizolid and linezolid in rat submandibular saliva and plasma. The results showed a strong correlation between the concentrations of these drugs in saliva and plasma, indicating that saliva is a useful matrix for therapeutic drug monitoring.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2023)
Article
Oncology
Keisuke Okamoto, Yoshitaka Saito, Atsushi Yamaguchi, Yoh Takekuma, Mitsuru Sugawara
Summary: This meta-analysis evaluated the effect of acid suppressants (ASs) on immune checkpoint inhibitors (ICIs) in cancer immunotherapy. The results showed that proton pump inhibitors (PPIs) reduced the therapeutic effect of ICIs, while histamine H2-receptor antagonists (H2RAs) had no effect. ASs did not affect immune-related adverse events (irAEs), but increased the risk of ICIs-induced acute kidney injury (AKI).
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Nursing
Keisuke Kagami, Reiko Oyamada, Tsubasa Watanabe, Sho Nakakubo, Takahiro Hayashi, Sumio Iwasaki, Tatsuya Fukumoto, Takayuki Usami, Kasumi Hayasaka, Shinichi Fujisawa, Chiaki Watanabe, Mutsumi Nishida, Takanori Teshima, Yusuke Niinuma, Isao Yokota, Yoh Takekuma, Mitsuru Sugawara, Nobuhisa Ishiguro
Summary: The aim of this study was to determine the risk factors for household transmission of the omicron variant of SARS-CoV-2. The study found that being unvaccinated, having an index case aged 6 years or younger, and staying at home with the index case were risk factors for household transmission. It is important for infected family members to live separately during the period of viral shedding to avoid household infection.
INTERNATIONAL JOURNAL OF NURSING PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Shunsuke Nashimoto, Shungo Imai, Mitsuru Sugawara, Yoh Takekuma
Summary: The Child-Pugh score and ALBI score are useful in assessing liver function and predicting drug clearance in patients with liver cirrhosis. This study found a correlation between the ALBI score and the plasma concentration and maintenance dose of voriconazole, an antifungal drug. However, the C : D ratio did not increase for intravenous administration in both the Child-Pugh and ALBI scores compared to the non-cirrhosis group.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Infectious Diseases
Hitoshi Yonezawa, Shingo Tanaka, Makito Tanaka, Ryo Kobayashi, Satoshi Takahashi
Summary: The aim of this study was to identify the risk factors for false positives in high-sensitivity HBsAg quantitative tests and reduce the need for neutralization tests. The results showed that younger age, female sex, lower HBsAg values, and reagent improvement were independent risk factors for false positives. The false-positive rate was highest in the range of 0.005-0.049 IU/mL.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Nobuaki Kobayashi, Katsushi Tanaka, Suguru Muraoka, Kohei Somekawa, Ayami Kaneko, Sousuke Kubo, Hiromi Matsumoto, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Summary: This study identified age, a negative T-SPOT.TB result, elevated CRP levels, and a high NLR as significant independent risk factors for death in hospitalized TB patients. These findings underscore the importance of these parameters in the risk stratification and management of hospitalized TB patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Naokuni Hishiya, Kenji Uno, Akiyo Nakano, Mitsuru Konishi, Seiya Higashi, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Yuki Suzuki, Saori Horiuchi, Nobuyasu Hirai, Yoshihiko Ogawa, Taku Ogawa, Ryuichi Nakano, Keiichi Mikasa, Kei Kasahara, Hisakazu Yano
Summary: This study revealed intestinal dysbiosis near a CD4 count of 350 in HIV-infected patients undergoing cART. These findings contribute to the understanding of intestinal damage and systemic inflammation in HIV infection.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)