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Biochemistry & Molecular Biology
Shuxin Li, Jianyi Lv, Xing Zhang, Qiuyu Zhang, Zhihui Li, Jing Lu, Xueyun Huo, Meng Guo, Xin Liu, Ran Gao, Jianan Gong, Changlong Li, Weiying Li, Tongmei Zhang, Jinghui Wang, Zhenwen Chen, Xiaoyan Du
Summary: This study investigates the role of RNA-binding protein ELAVL4 and long noncoding RNA LYPLAL1-DT in small cell lung cancer (SCLC). The results show that LYPLAL1-DT negatively regulates miR-204-5p, leading to the upregulation of PFN2 and promoting SCLC cell proliferation, migration, and invasion.
Article
Cell Biology
Tao Hou, Weichao Dan, Tianjie Liu, Bo Liu, Yi Wei, Chenyang Yue, Taotao Que, Yuzeshi Lei, Zixi Wang, Jin Zeng, Yizeng Fan, Lei Li
Summary: This study reveals that the deubiquitinating enzyme OTUD5 activates the mTOR signaling pathway to promote bladder cancer progression. OTUD5 stabilizes the function of RNF186, a RING-type E3 ligase, leading to the degradation of sestrin2, an inhibitor of the mTOR signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Shuuhei Hirose, Tsuyoshi Waku, Misato Tani, Haruka Masuda, Keiko Endo, Sanae Ashitani, Iori Aketa, Hina Kitano, Sota Nakada, Ayaka Wada, Atsushi Hatanaka, Tsuyoshi Osawa, Tomoyoshi Soga, Akira Kobayashi
Summary: Cancer cells utilize the NRF3-mTORC1 axis, specifically in response to arginine, to promote robust growth by activating metabolic pathways and enhancing lysosome function. Inhibition of this axis impairs mitochondrial function and leads to cancer cell apoptosis, while aberrant upregulation of the axis results in tumor growth and poor prognosis. This study highlights the importance of NRF3 in arginine-dependent mTORC1 activation and provides insights into the pathophysiological role of the NRF3-mTORC1 axis in cancer development.
Article
Multidisciplinary Sciences
Yui Kotani, Mami Sumiyoshi, Megumi Sasada, Toshio Watanabe, Satoshi Matsuda
Summary: This study reveals that Arf1 plays an important role in the activation of mTORC1 and cell proliferation in mast cells, but has little impact on degranulation and cytokine secretion. This finding suggests the potential of Arf1 as a therapeutic target for mast cell proliferative disorders.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Asmaa Y. Abuhamad, Nurul Nadia Mohamad Zamberi, Sakari Vanharanta, Siti Nur Hasanah Mohd Yusuf, M. Aiman Mohtar, Saiful Effendi Syafruddin
Summary: This study found that clear cell renal cell carcinoma (ccRCC) cells are able to secrete PDGFB, which can activate the mTORC1 signaling pathway and promote the development of ccRCC. The level of PDGFB secretion was positively correlated with the expression of intracellular KLF6 and PDGFB. Reintroduction of either KLF6 or PDGFB sustained mTORC1 signaling activity in KLF6-targeted ccRCC cells. Conditioned media of PDGFB-overexpressing ccRCC cells was able to re-activate mTORC1 activity in KLF6-targeted cells. Cancer cell-derived PDGFB can mediate mTORC1 signaling pathway activation in ccRCC, further solidifying the association between the KLF6-PDGFB axis and mTORC1 signaling pathway activity in ccRCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Zixi Wang, Di Guan, Jianxin Huo, Subhra K. Biswas, Yuhan Huang, Yuansheng Yang, Shengli Xu, Kong-Peng Lam
Summary: The study demonstrates that IL-10 upregulates both glycolysis and oxidative phosphorylation in human NK cells, crucial for their enhanced effector functions. Mechanistically, it is revealed that IL-10 activates the mammalian target of rapamycin complex 1 (mTORC1) to regulate metabolic reprogramming in human NK cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Young-Jun Ju, Hee-Ok Kim, Cheol-Heui Yun, Jae-Ho Cho
Summary: The study revealed that STAT1 plays a crucial role in maintaining the quiescence of naive CD8(+) T cells, with its deficiency leading to increased proliferation and abnormal expansion of memory/activated cells. This phenomenon is paradoxically dependent on type I interferon and its alternative signaling pathway.
Article
Immunology
Jun Jin, Chulwoo Kim, Qiong Xia, Timothy M. Gould, Wenqiang Cao, Huimin Zhang, Xuanying Li, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Cornelia M. Weyand, Jorg J. Goronzy
Summary: mTORC1 activation in late endosomes, rather than lysosomes, is crucial for T cell responses in older adults, who have sustained mTORC1 activity despite lysosomal dysfunction. Deficiency of SLC7A5 and VPS39 reduces mTORC1 activity in older individuals, suggesting a potential strategy to enhance T cell immunity.
SCIENCE IMMUNOLOGY
(2021)
Article
Oncology
Naghib Bogere, Felix Bongomin, Andrew Katende, Blair Andrew Omaido, Elizabeth Namukwaya, Harriet Mayanja-Kizza, Victoria Walusansa
Summary: In Uganda, adenocarcinoma is the predominant histologic subtype of lung cancer, with a majority of patients being females and non-smokers. Late diagnosis and poor overall survival are common.
Article
Oncology
Ga Bin Park, Jee-Yeong Jeong, Sangbong Choi, Yoo Sang Yoon, Daejin Kim
Summary: High doses of thyroid hormone induce a stress response in mice, leading to increased dendritic length and number, as well as changes in brain structure and related molecular expression.
Article
Oncology
Frantisek Zitricky, Asta Foersti, Akseli Hemminki, Kari Hemminki
Summary: This study modeled survival data from the NORDCAN database and analyzed survival rates of breast cancer patients in Denmark, Finland, Norway, and Sweden from 1971 to 2020. The results showed that Sweden had the highest survival rates, but all countries showed improvements over time and approached the levels of Sweden. The risk of recurrence was higher in the 2-5 year period, which resulted in higher 10/5-year survival rates compared to 5/1-year survival rates. The study suggests that late mortality is a critical factor limiting survival in breast cancer.
Review
Cell Biology
Jiajun Zhu, Hua Wang, Xuejun Jiang
Summary: In this review, Zhu et al. provide an overview of the current understanding of how mTORC1 activity is connected to cell death regulation through metabolic and signaling pathways. The authors focus on the interaction between mTORC1 and ferroptosis, an iron-dependent cell death program, and highlight the importance of further investigating the interplay between mTORC1 and cell death pathways.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guohua Chen, Guoli Zhou, Aaron Lotvola, James G. Granneman, Jian Wang
Summary: ABHD5 is a coactivator of ATGL that functions as a tumor suppressor by inhibiting cancer cell growth through activating lipolysis leading to downregulation of protein synthesis and inhibition of mTORC1 via the AMPK pathway.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sungyun Cho, Gina Lee, Brian F. Pickering, Cholsoon Jang, Jin H. Park, Long He, Lavina Mathur, Seung-Soo Kim, Sunhee Jung, Hong-Wen Tang, Sebastien Monette, Joshua D. Rabinowitz, Norbert Perrimon, Samie R. Jaffrey, John Blenis
Summary: The study found that mTORC1 and its downstream kinase S6K enhance the translation of WTAP, affecting cellular metabolism and cancer progression. WTAP regulates MXD2 to impact the proliferation of mTORC1-activated cancer cells, revealing a mechanism by which mTORC1 stimulates oncogenic signaling through m(6)A RNA modification.
Editorial Material
Multidisciplinary Sciences
Soizic Garaud, Marie-Caroline Dieu-Nosjean, Karen Willard-Gallo
Summary: Tumor-infiltrating lymphocytes, organized in tertiary lymphoid structures and specific subpopulation composition/balances, play a crucial role in stimulating cellular crosstalk and anti-tumor immunity.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Jaeyoung Cho, Hyuck-Se Kweon, Sung-Oh Huh, Ali Sadra
ANIMAL CELLS AND SYSTEMS
(2018)
Correction
Oncology
Kausik Bishayee, Khadija Habib, Uddin Md. Nazim, Jieun Kang, Aniko Szabo, Sung-Oh Huh, Ali Sadra
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Kausik Bishayee, Uddin Md. Nazim, Vijay Kumar, Jieun Kang, Jaebong Kim, Sung-Oh Huh, Ali Sadra
Summary: In MYCN-amplified neuroblastoma, treatment with the HDAC inhibitor vorinostat leads to a reprogramming of the glycolytic pathway, increasing fatty acid oxidation and oxidative phosphorylation. This reprogramming is correlated with reduced levels of MYCN and increased levels of PPARD transcription factors. Additionally, the combination of HDAC and mTORC1 inhibitors increases reactive oxygen species levels. The glycolytic enzymes HK2 and GPI are most affected by this combination. Overall, this combination treatment shows promising results without causing significant toxicity in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Uddin Md. Nazim, Kausik Bishayee, Jieun Kang, Dongkwan Yoo, Sung-Oh Huh, Ali Sadra
Summary: Through screening anticancer drugs, the combination of ponatinib and sirolimus was found to synergistically inhibit tumor growth in multiple myeloma. The combination therapy prevents metabolic escape, blocks oxidative phosphorylation, and increases reactive oxygen species. The treatment effectively inhibits cell viability with no overt toxicity.
Article
Biochemistry & Molecular Biology
Heeyoung Park, Chang-Wook Lee, Jieun Kang, Ali Sadra, Sung-Oh Huh
Summary: This study examined the effect of environmental glutamine on the expression of tryptophan hydroxylase 1 (TPH1) gene in mouse mastocytoma cells. The results showed that glutamine could stabilize the mRNA levels of TPH1 and enhance its expression.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Khadija Habib, Kausik Bishayee, Jieun Kang, Ali Sadra, Sung-Oh Huh
Summary: Rbms1 plays a crucial role in the migration, polarization, and differentiation of neuronal progenitors in neocortex development. Its expression is highest in the early development of the cortex. Knockdown of Rbms1 delays the transition of neuronal progenitors from multipolar to bipolar state and causes a delay in radial migration. Additionally, Rbms1 binds and stabilizes the mRNA for Efr3a, a signaling adapter protein, which is required for migration and maturation of neuronal progenitors in the developing neocortex.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Khadija Habib, Kausik Bishayee, Jieun Kang, Au Sadra, Sung-Oh Huh
Summary: The RNA-binding protein Rbms1 plays a vital role in the radial migration, polarization, and differentiation of neuronal progenitors in neocortex development. Rbms1 stabilizes the mRNA for Efr3a, a signaling adapter protein, thereby promoting the migration and maturation of neuronal progenitors.
MOLECULES AND CELLS
(2022)
Article
Medicine, Research & Experimental
Seunghyuk Choi, Ali Sadra, Jieun Kang, Jae Ryun Ryu, June Hoan Kim, Woong Sun, Sung-Oh Huh
EXPERIMENTAL NEUROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Nam-Ho Kim, Ali Sadra, Hee-Young Park, Sung-Min Oh, Jerold Chun, Jeong Kyo Yoon, Sung-Oh Huh
MOLECULES AND CELLS
(2019)
Article
Cell Biology
Ali Sadra, Hyuck-Se Kweon, Sung-Oh Huh, Jaeyoung Cho
ANIMAL CELLS AND SYSTEMS
(2017)
Article
Biochemistry & Molecular Biology
Md. Ataur Rahman, Kausik Bishayee, Ali Sadra, Sung-Oh Huh
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2017)