Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy

PI3K inhibitors are finally coming of age

(2021) Bart Vanhaesebroeck et al.   NATURE REVIEWS DRUG DISCOVERY

BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair

(2021) Shaolu Zhang et al.   Cell Death & Disease

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer

(2020) Lei Zhang et al.   Molecular Cancer

Digoxin Enhances the Anticancer Effect on Non-Small Cell Lung Cancer While Reducing the Cardiotoxicity of Adriamycin

(2020) Yingying Wang et al.   Frontiers in Pharmacology

Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3

(2020) Chiharu Sogawa et al.   Cancers

Time Course and Management of Key Adverse Events During the Randomized Phase 3 SOLAR-1 Study of PI3K Inhibitor Alpelisib Plus Fulvestrant in Patients With HR-Positive Advanced Breast Cancer

(2020) H.S. Rugo et al.   ANNALS OF ONCOLOGY

Rethinking the role of hydroxychloroquine in the treatment of COVID‐19

(2020) Eric A. Meyerowitz et al.   FASEB JOURNAL

Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer

(2020) Wenjing Wang et al.   Molecular Cancer

PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance

(2020) Maddison Rose et al.   Frontiers in Cell and Developmental Biology

Biomimetic carrier-free nanoparticle delivers digoxin and doxorubicin to exhibit synergetic antitumor activity in vitro and in vivo

(2020) Zhe Zhang et al.   CHEMICAL ENGINEERING JOURNAL

NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression

(2019) Chunjing Bian et al.   Nature Communications

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial

(2019) Panagiotis A Konstantinopoulos et al.   LANCET ONCOLOGY

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

(2019) Takafumi Suzuki et al.   Cell Reports

Biomarkers of response and resistance to PI3K inhibitors in estrogen receptor-positive breast cancer patients and combination therapies involving PI3K inhibitors

(2019) M Brandão et al.   ANNALS OF ONCOLOGY

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

(2019) Jonathan Kim et al.   NATURE

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Phosphatidylinositol 3-kinase β and δ isoforms play key roles in metastasis of prostate cancer DU145 cells

(2018) Zhe Zhang et al.   FASEB JOURNAL

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

(2018) Minxian Qian et al.   eLife

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

(2018) Benjamin D. Hopkins et al.   NATURE

The phase 3 DUO trial: duvelisib vs ofatumumab in relapsed and refractory CLL/SLL

(2018) Ian W. Flinn et al.   BLOOD

Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells

(2018) Ning Ji et al.   CANCER LETTERS

PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.

(2018) Vito W Rebecca et al.   Cancer Discovery

PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8+ T-cell activity

(2018) Larissa S. Carnevalli et al.   Journal for ImmunoTherapy of Cancer

Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma

(2017) Martin Dreyling et al.   JOURNAL OF CLINICAL ONCOLOGY

ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma

(2017) M R Yun et al.   ONCOGENE

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

(2017) Smruthi Vijayaraghavan et al.   Nature Communications

Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice

(2017) Chunfeng Li et al.   EBioMedicine

Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy

(2017) Wennan Zhao et al.   Acta Pharmaceutica Sinica B

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

(2016) Hai Hu et al.   CELL

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses

(2016) Jiqing Sai et al.   CLINICAL CANCER RESEARCH

Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis

(2016) Hui Guo et al.   HEPATOLOGY

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells

(2016) Yaochen Wang et al.   Oncotarget

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

(2016) Ran Wang et al.   Scientific Reports

Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ

(2015) Sarit Schwartz et al.   CANCER CELL

DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics

(2015) Mrinal Srivastava et al.   CHEMISTRY & BIOLOGY

mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer

(2015) W. Mo et al.   CLINICAL CANCER RESEARCH

FDA Approval: Idelalisib Monotherapy for the Treatment of Patients with Follicular Lymphoma and Small Lymphocytic Lymphoma

(2015) B. W. Miller et al.   CLINICAL CANCER RESEARCH

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

(2015) K. D. Rainsford et al.   INFLAMMOPHARMACOLOGY

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

In vitro multifaceted activities of a specific group of novel phosphatidylinositol 3-kinase inhibitors on hotspot mutant PIK3CA

(2014) Dexin Kong et al.   INVESTIGATIONAL NEW DRUGS

Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity

(2014) Robin Mathew et al.   MOLECULAR CELL

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

(2014) C. Gorrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

Autophagy is differentially induced in prostate cancer LNCaP, DU145 and PC-3 cells via distinct splicing profiles of ATG5

(2012) Dong-Yun Ouyang et al.   Autophagy

JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs

(2012) Dexin Kong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363

(2012) F. Lamoureux et al.   CLINICAL CANCER RESEARCH

PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition

(2012) Yasir H. Ibrahim et al.   Cancer Discovery

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

(2012) Ashish Juvekar et al.   Cancer Discovery

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39

(2010) Dexin Kong et al.   EUROPEAN JOURNAL OF CANCER

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair

(2010) L Tian et al.   ONCOGENE

Nuclear phosphoinositide 3-kinase   controls double-strand break DNA repair

(2010) A. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-dependent generation of reactive oxygen species in human astrocytoma cells contributes to resistance to TRAIL-mediated apoptosis

(2009) K Choi et al.   CELL DEATH AND DIFFERENTIATION

ATM-Dependent Hyper-Radiosensitivity in Mammalian Cells Irradiated by Heavy Ions

(2009) Lian Xue et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS