Diterpene glycosides from Holothuria scabra exert the α-synuclein degradation and neuroprotection against α-synuclein-Mediated neurodegeneration in C. elegans model

Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases

(2020) Taejoon Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Downregulation of eEF1A/EFT3-4 Enhances Dopaminergic Neurodegeneration After 6-OHDA Exposure in C. elegans Model

(2020) Pawanrat Chalorak et al.   Frontiers in Neuroscience

Haloperidol Interactions with the dop-3 Receptor in Caenorhabditis elegans

(2020) Bárbara Nunes Krum et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective and Neurorestorative Effects of Holothuria scabra Extract in the MPTP/MPP+-Induced Mouse and Cellular Models of Parkinson’s Disease

(2020) Kunwadee Noonong et al.   Frontiers in Neuroscience

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models

(2019) Hayate Javed et al.   Frontiers in Pharmacology

Marine natural products as source of new drugs: a patent review (2015-2018)

(2019) Pravin Shinde et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

α‐Synuclein toxicity in yeast and human cells is caused by cell cycle re‐entry and autophagy degradation of ribonucleotide reductase 1

(2019) Belém Sampaio‐Marques et al.   AGING CELL

Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism

(2019) Fiona Limanaqi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells

(2019) Jianqun Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Holothuria scabra extracts possess anti-oxidant activity and promote stress resistance and lifespan extension in Caenorhabditis elegans

(2018) Prapaporn Jattujan et al.   EXPERIMENTAL GERONTOLOGY

Autophagy during ageing - from Dr Jekyll to Mr Hyde

(2018) Thomas Wilhelm et al.   FEBS Journal

Distribution and dynamic expression of serotonin and dopamine in the nervous system and ovary of Holothuria scabra during ovarian maturation

(2018) Arada Chaiyamoon et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY

A new clerodane furano diterpene glycoside from Tinospora cordifolia triggers autophagy and apoptosis in HCT-116 colon cancer cells

(2018) Neha Sharma et al.   JOURNAL OF ETHNOPHARMACOLOGY

Transcriptomic discovery and comparative analysis of neuropeptide precursors in sea cucumbers (Holothuroidea)

(2018) Saowaros Suwansa-ard et al.   PEPTIDES

Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota

(2018) Nawaphat Malaiwong et al.   BIOMEDICINE & PHARMACOTHERAPY

Structure and Anti-Inflammatory Activity of a New Unusual Fucosylated Chondroitin Sulfate from Cucumaria djakonovi

(2018) Nadezhda Ustyuzhanina et al.   Marine Drugs

Natural Compounds for the Management of Parkinson’s Disease and Attention-Deficit/Hyperactivity Disorder

(2018) Juan Carlos Corona   Biomed Research International

Structural Elucidation and Biological Activity of a Highly Regular Fucosylated Glycosaminoglycan from the Edible Sea Cucumber Stichopus herrmanni

(2017) Xiaomei Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update

(2017) Valerie Voon et al.   LANCET NEUROLOGY

Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease

(2017) Tim E. Moors et al.   Molecular Neurodegeneration

Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing

(2017) Pawanrat Chalorak et al.   NUTRITIONAL NEUROSCIENCE

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies

(2016) Maria Xilouri et al.   MOVEMENT DISORDERS

Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra

(2016) Yang Heng et al.   TOXICOLOGY LETTERS

Systems pharmacology-based drug discovery for marine resources: An example using sea cucumber (Holothurians)

(2015) Yingying Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

(2015) Mustafa T. Ardah et al.   NEUROBIOLOGY OF DISEASE

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

Autophagy across the eukaryotes

(2012) Jason S. King   Autophagy

Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease

(2012) A. J. Harrington et al.   JOURNAL OF NEUROSCIENCE

Beclin 1-independent autophagy contributes to apoptosis in cortical neurons

(2011) Yulia Grishchuk et al.   Autophagy

Jewel of the seabed: sea cucumbers as nutritional and drug candidates

(2011) Peck Loo Kiew et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

High-Value Components and Bioactives from Sea Cucumbers for Functional Foods—A Review

(2011) Sara Bordbar et al.   Marine Drugs

Cryptotanshinione Inhibits β-Amyloid Aggregation and Protects Damage from β-Amyloid in SH-SY5Y Cells

(2011) Zhengrong Mei et al.   NEUROCHEMICAL RESEARCH

Autophagy and misfolded proteins in neurodegeneration

(2010) Daniel J. Metcalf et al.   EXPERIMENTAL NEUROLOGY

Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against β-amyloid peptide-induced toxicity in SH-SY5Y cells

(2009) Chun Shi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Neuroprotective effects of the new diterpene, CBNU06 against beta-amyloid-induced toxicity through the inhibition of NF-kappaB signaling pathway in PC12 cells

(2009) Hyo-Shin Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ethanol preference inC. elegans

(2009) J. Lee et al.   GENES BRAIN AND BEHAVIOR

Molecular mechanisms of α-synuclein neurodegeneration

(2008) Elisa A. Waxman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice

(2006) Masaki Wakamatsu et al.   NEUROBIOLOGY OF AGING