Article
Polymer Science
Randa Mohammed Zaki, Mohamed A. Ibrahim, Doaa H. Alshora, Amal El Sayeh Abou El Ela
Summary: This study aimed to prepare Span 60-based elastic nanovesicles using the adapted ethanol injection method, and evaluate their ability to improve transdermal permeation of tacrolimus. Different concentrations and types of penetration enhancers were assessed for their impact on the physicochemical properties of the nanovesicles. The results showed significant enhancement in in vitro release compared to pure drug suspension.
Article
Biochemistry & Molecular Biology
Asmaa Ashraf Nemr, Galal Mohamed El-Mahrouk, Hany Abdo Badie
Summary: The study successfully prepared spanlastics to enhance the transdermal delivery of CLZ and confirmed its effectiveness and safety through experiments.
JOURNAL OF LIPOSOME RESEARCH
(2022)
Article
Instruments & Instrumentation
Tanushree Gupta, Prathmesh Kenjale, Varsha Pokharkar
Summary: The study developed an alternative transdermal delivery system for RLX, which improved drug absorption and bioavailability by optimizing the formulation. The system showed safety and stability, and has the potential to overcome issues associated with existing oral dosage forms of RLX.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Mohammad A. Altamimi, Afzal Hussain, Sultan Alshehri, Syed Sarim Imam, Usamah Abdulrahman Alnemer
Summary: The study compared the skin permeation of luteolin (LUT) using different carrier systems and found that cationic nanoemulsions (CNE) prepared with bergamot oil have significant advantages in permeation.
Article
Pharmacology & Pharmacy
Deepal Vora, Amruta Dandekar, Sonalika Bhattaccharjee, Onkar N. Singh, Vivek Agrahari, M. Melissa Peet, Gustavo F. Doncel, Ajay K. Banga
Summary: In vitro permeation studies have confirmed the potential of reservoir-based polymeric gels as a transdermal delivery system for the weekly administration of Raloxifene (RLX), as they successfully released the required amount of RLX over a 7-day period.
Article
Nanoscience & Nanotechnology
Manar Adel Abdelbari, Shereen Sameh El-mancy, Ahmed Hassen Elshafeey, Aly Ahmed Abdelbary
Summary: This study aimed to encapsulate the antifungal drug clotrimazole (CLT) into spanlastics (SPs) to provide controlled ocular delivery. The optimal formulation S1 showed high encapsulation efficiency, elastic vesicles, sustained release profile, and superior inhibition of Candida albicans development compared to CLT suspension. In vivo histopathological examination confirmed the safety of S1 for ophthalmic application in rabbits, demonstrating the efficacy of SPs for ocular delivery of CLT.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Niha Sultana, Asad Ali, Ayesha Waheed, Bushra Jabi, Mohd Yaqub Khan, Mohd. Mujeeb, Yasmin Sultana, Mohd. Aqil
Summary: Osteoporosis is a fatal bone disease that contributes significantly to human mortality and economic burden. A microneedle transdermal patch loaded with optimized formulation nanotransfersomes containing Risedronate Sodium and Ursolic acid has been developed to improve osteoporosis treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Omar Awad Alsaidan, Ameeduzzafar Zafar, Rayan Hamood Al-Ruwaili, Mohd Yasir, Sami I. Alzarea, Aseel Awad Alsaidan, Lubhan Singh, Mohammad Khalid
Summary: This research aimed to develop an AN-NS gel for improved transdermal delivery. The optimized AN-NS formulation showed improved drug release and antioxidant activity compared to the pure AN gel. These findings suggest that niosomes-laden gel is a good carrier of drugs to improve transdermal delivery and therapeutic efficacy.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Manar Adel Abdelbari, Amira A. El-Gazar, Aly Ahmed Abdelbary, Ahmed Hassen Elshafeey, Shaimaa Mosallam
Summary: The objective of this research was to encapsulate niflumic acid into bilosomes for transdermal delivery and effective treatment of osteoarthritis. The optimal formulation (B5) contained 5 mg of sodium taurocholate and 5 mg of Brij-93, showing high entrapment efficiency and suitable particle size. B5 gel exhibited higher drug permeation across rat skin compared to NA gel and demonstrated superior efficacy in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, General & Internal
Tory R. Spindle, Dennis J. Sholler, Edward J. Cone, Timothy P. Murphy, Mahmoud ElSohly, Ruth E. Winecker, Ronald R. Flegel, Marcel O. Bonn-Miller, Ryan Vandrey
Summary: This study evaluated the accuracy of CBD and THC labeling in topical cannabinoid products and found that they are often inaccurately labeled and many contain THC. These findings suggest the need for clinical studies to determine whether topical cannabinoid products with THC can produce psychoactive effects or positive drug tests for cannabis.
Article
Polymer Science
Farzaneh Sabbagh, Beom-Soo Kim
Summary: Nicotinamide mononucleotide (NMN) is a precursor of nicotinamide adenine dinucleotide that plays a crucial role in intracellular redox reactions. Oral NMN capsules currently have low bioavailability due to metabolism and excretion. To address this issue, PVA-based microneedle patches were developed for transdermal delivery of NMN. The optimal molecular weight PVA microneedle containing NMN and CMC achieved a high release rate of 91.94% in 18 hours.
Article
Pharmacology & Pharmacy
Mohamed M. Badran, Nadia N. Alouny, Basmah N. Aldosari, Ahlam M. Alhusaini, Amal El Sayeh Abou El Ela
Summary: The study developed a sustained-release transdermal GLP film using chitosan-coated deformable liposomes (DLs) to overcome the challenges associated with oral administration of the drug. The DLs showed improved drug transdermal delivery compared to conventional liposomes (CL), with high stability and deformability. The in vitro release study confirmed sustained release of GLP, and coating with CS further enhanced the sustained release. The transdermal films demonstrated promising pharmacokinetic profiles and higher hypoglycemic effect compared to oral GLP, indicating the potential of systemic action through local topical delivery.
Article
Pharmacology & Pharmacy
Jiawei Ling, Yanan Du, Yuze Sheng, Weiqin Wang, Hangyi Wu, Guorong Chen, Huixia Lv
Summary: In vitro permeation test (IVPT) is commonly used for evaluating topical preparations and transdermal drug delivery systems. However, the storage of ex vivo skin for IVPT is challenging. This study investigated the efficacy of two cryopreservation media, 10% DMSO and 10% GLY, for preserving rat and pig skin at -20°C and -80°C, and found that -80°C storage in 10% DMSO or 10% GLY was optimal for maintaining skin viability and permeability. The results also suggested that skin viability could serve as a potential indicator for IVPT skin.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Francesca Ferrara, Mascia Benedusi, Franco Cervellati, Maddalena Sguizzato, Leda Montesi, Agnese Bondi, Markus Drechsler, Walter Pula, Giuseppe Valacchi, Elisabetta Esposito
Summary: In this study, transethosomes were explored as potential delivery systems for dimethyl fumarate. Formulative studies were conducted to investigate the effects of various compositions on the morphology and drug entrapment capacity of vesicles. Results showed that certain formulations were able to effectively improve wound healing and control drug release, indicating their potential application in wound treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Instruments & Instrumentation
Guilherme L. Alves, Fernanda V. Teixeira, Priscila Bianca Rodrigues da Rocha, Anna Paula Krawczyk-Santos, Ligia Marquez Andrade, Marcilio Cunha-Filho, Ricardo N. Marreto, Stephania F. Taveira
Summary: The transdermal administration of raloxifene hydrochloride (RLX)-loaded nanostructured lipid carriers (NLCs) has been proposed to overcome its low oral bioavailability. Preformulation studies, in vitro release studies, and skin permeation studies revealed that NLC7 and NLC8 are the most promising formulations for controlling RLX release and potential use in transdermal drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemical Research Methods
Ritu Tiwari, Amit Kumar, Pavitra Solanki, Mahaveer Dhobi, Velusamy Sundaresan, Vivekanandan Kalaiselvan, Rajeev Singh Raghuvanshi
Summary: The study developed a reverse-phase HPLC method for the quantification of plumbagin using an AQbD approach, optimizing critical method parameters through Box-Behnken Design experiment and validation following ICH guidelines. The developed method showed high precision and sensitivity, with the highest plumbagin content found in P. indica roots from different climatic conditions, suggesting the potential application of AQbD approach in optimizing plant metabolite extraction in other plant systems.
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
(2021)
Review
Pharmacology & Pharmacy
Mohd Danish Ansari, Zoya Saifi, Jayamanti Pandit, Iram Khan, Pavitra Solanki, Yasmin Sultana, Mohd Aqil
Summary: Nanotechnology-based drug delivery systems have revolutionized drug delivery. Spanlastics, an elastic nanovesicle, has the ability to carry a wide range of drug molecules and is suitable for various routes of administration. This review provides an overview of the composition, structure, advantages, and mechanism of drug penetration of spanlastics.
Article
Pharmacology & Pharmacy
Iram Khan, Jayamanti Pandit, Shakeeb Ahmed, Saima Zameer, Nikita, Saeem Ahmad, Shahnaj Bano, Mohd Danish Ansari, Pavitra Solanki, Rao Nargis Jahan, Ayesha Waheed, Mohd Aqil, Yasmin Sultana
Summary: The study aimed to develop biodegradable nanofibers loaded with lomustine for the treatment of primary and metastatic brain tumors. The results showed that the nanofibers had desired size and drug release characteristics, improving lomustine permeation in the cerebral cavity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Saeem Ahmad, Iram Khan, Jayamanti Pandit, Nasr A. Emad, Shahnaj Bano, Khalid Imtiyaz Dar, M. Moshahid Alam Rizvi, Mohd Danish Ansari, Mohd. Aqil, Yasmin Sultana
Summary: This study successfully developed chitosan-coated PLGA nanoparticles for nose-to-brain delivery of carmustine. The optimized nanoparticles showed satisfactory levels in terms of particle size, entrapment efficiency, drug release, and permeability. The results suggested that chitosan-coated nanoparticles could be a promising approach for delivering carmustine to treat Glioblastoma multiforme via intranasal administration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Mohit, Pankaj Kumar, Pavitra Solanki, Bharti Mangla, Geeta Aggarwal
Summary: The study developed a gefitinib-phospholipid complex (GB-PC-90G) using the solvent evaporation method and job plot. The complexes were confirmed and characterized using FTIR, DSC, and SEM morphologies. The dissolution study showed improved drug release through complexation at pH 1.2. The complex was loaded into a nanoemulsion (GB-PC90G@NE) using caproyl 90, Transcutol HP, and Tween 80 as the oil, surfactant, and co-surfactant, respectively. In vitro studies showed sustained release behavior of the drug from the nanoemulsion.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Instruments & Instrumentation
Pavitra Solanki, Mohd Danish Ansari, Mohd Iqbal Alam, Mohd Aqil, Farhan J. Ahmad, Yasmin Sultana
Summary: This study developed an orally effective nanoformulation of disodium pamidronate for the treatment of osteoporosis. Through rational design and optimization, a commercially potential self nano-emulsifying drug delivery system (SNEDDS) was developed, which showed improved oral bioavailability and enhanced anti-osteoporotic activity. The study provided significant achievements in the treatment of postmenopausal osteoporosis and may lead to the use of nanotherapeutic-driven emerging biodegradable carriers-based drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Anjali Rathee, Pavitra Solanki, Surajpal Verma, Divya Vohora, Mohammad Javed Ansari, Alhussain Aodah, Kanchan Kohli, Yasmin Sultana
Summary: This study developed a reverse-phase HPLC method using the quality-by-design approach to estimate the content of posaconazole and hemp seed oil simultaneously in nanomicelles formulation. The separation of posaconazole and hemp seed oil was successfully achieved, and this is the first study to develop and quantify posaconazole and hemp seed oil nanomicelles. The proposed method was effective for estimating the content of drugs from their nanoformulation and suitable for both in vivo and in vitro research.
Meeting Abstract
Geriatrics & Gerontology
P. Solanki, Y. Sultana, M. Aqil, F. J. Ahmad
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Geriatrics & Gerontology
P. Solanki, M. Aqil, F. J. Ahmad, Y. Sultana
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Geriatrics & Gerontology
P. Solanki, M. Aqil, F. J. Ahmad, Y. Sultana
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Pathology
E. Guryanova, O. Vorobyeva, D. Lastochkina, N. Zhuravleva
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)