期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 67, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jddst.2021.103032
关键词
Oleic acid; Topical delivery; Nanocarriers; Dermal; Skin retention; Penetration enhancer
This article discusses the use of oleic acid in nano-carriers for enhanced drug penetration and therapeutic effectiveness in skin delivery. It highlights the synergy between oleic acid and nano-carriers, and provides a comprehensive review of their characteristics and evaluation methods.
Oleic acid (OA), the naturally occurring fatty acid, is a multifunctional pharmaceutical excipient with penetration enhancing property for effective skin applications. Topical drug delivery via nano-carriers is also a widely used approach to improve dermal permeation and drug retention. Nano-carriers could achieve a sustainment drug release, hence reduce adverse effects such as skin irritation accompanied by the immediate release of some actives. The present review particularly emphasizes the synergy between both approaches for enhanced drug penetration, skin retention and therapeutic effectiveness in the treatment of several cutaneous diseases. Hence, defining exactly the characteristics of the various OA-based nanosystems; composition, viscosity, physicochemical properties, and focusing on their effects on enhanced dermal drug delivery are accentuated. Methods used to assess their effectiveness in skin delivery are thoroughly discussed. The overall in vitro, in vivo and/or clinical outcomes associated with these nano-platforms are highlighted based on literature during the last ten years.
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