Article
Gastroenterology & Hepatology
Rebecca J. Birch, Nicholas Burr, Venkataraman Subramanian, Jim P. Tiernan, Mark A. Hull, Paul Finan, Azmina Rose, Matthew Rutter, Roland Valori, Amy Downing, Eva J. A. Morris
Summary: This study investigated the epidemiology and outcomes of inflammatory bowel disease-associated colorectal cancer (IBD-CRC). It found that IBD patients have a higher risk of developing CRC, are diagnosed at a younger age, and have worse outcomes compared to sporadic CRC. Further research is needed to understand the reasons behind these differences and inform screening, surveillance, and treatment strategies for this high-risk group.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Tawnya M. Hansen, Zoann Nugent, Charles N. Bernstein, N. Jewel Samadder, Sanjay K. Murthy, Harminder Singh
Summary: The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years. There is a high proportion of post colonoscopy CRC among IBD-CRC patients, which has remained unchanged over the years and requires detailed root-cause analysis and interventions.
Review
Gastroenterology & Hepatology
Jordan E. Axelrad, Raymond K. Cross
Summary: Patients with chronic ulcerative and Crohn's colitis have a higher risk of developing colorectal neoplasia (CRN [dysplasia and cancer]) compared to the general population. Risk factors for CRN include the extent of colitis, cumulative inflammatory burden, family history of colorectal cancer, and primary sclerosing cholangitis. Best practices for preventing CRN involve controlling colonic inflammation, conducting high quality surveillance colonoscopy with or without enhanced imaging techniques, removing visible dysplasia if possible, and considering colectomy for patients with unresectable dysplasia, invisible multifocal low-grade dysplasia, or invisible high-grade dysplasia. The decision to stop dysplasia surveillance should be individualized and based on factors such as age, frailty, comorbid conditions, life expectancy, previous surveillance exam results, and risk factors for CRN.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Jose Maria Huguet, Luis Ferrer-Barcelo, Patricia Suarez, Eva Sanchez, Jose David Prieto, Victor Garcia, Javier Sempere
Summary: The detection of dysplasia in IBD patients is important and chromoendoscopy with targeted biopsy remains the preferred technique. However, other techniques such as virtual chromoendoscopy are being compared due to their similar results and fewer technical difficulties. New endoscopy techniques and improved devices have the potential to revolutionize the screening and follow-up of dysplasia in IBD patients. Further research is needed to define the optimal follow-up strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Adam Faye, James C. Slaughter, Noam Harpaz, Steven H. Itzkowitz, Shailja C. Shah
Summary: Colorectal strictures in patients with inflammatory bowel disease (IBD) are not independently associated with the risk of advanced colorectal neoplasia (ACRN) or colectomy, according to a retrospective cohort analysis. Further multicenter, prospective studies are needed to confirm these findings.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Mohammed Deputy, Kapil Sahnan, Guy Worley, Komal Patel, Violeta Balinskaite, Alex Bottle, Paul Aylin, Elaine M. Burns, Ailsa Hart, Omar Faiz
Summary: The Covid-19 pandemic has had a detrimental effect on inflammatory bowel disease (IBD) services, leading to delays in emergency care and access to investigations and surgeries. A study in England found significant decreases in hospital attendances for acute ulcerative colitis (UC) and acute Crohn's disease (CD), as well as a decrease in the volume of IBD procedures and investigations. The study also highlighted the importance of prioritizing care for patients with IBD to prevent clinical harm and a decrease in quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Surgery
Can Lu, Josefine Schardey, Tao Zhang, Alexander Crispin, Ulrich Wirth, Konrad W. Karcz, Alexandr Bazhin, Joachim Andrassy, Jens Werner, Florian Kuehn
Summary: This study conducted a systematic review and meta-analysis to compare the survival outcomes of IBD-associated and non-IBD-associated CRC. The results showed that IBD-CRC patients had a significantly worse overall survival than those without IBD. This may be attributed to more aggressive histological characteristics and a lower rate of R0 resections at the primary tumor site.
Review
Medicine, General & Internal
Ugo Grossi, Gaetano Gallo, Gian Luca Di Tanna, Umberto Bracale, Mattia Ballo, Elisa Galasso, Andrea Kazemi Nava, Martino Zucchella, Francesco Cinetto, Marcello Rattazzi, Carla Felice, Giacomo Zanus
Summary: The safety and effectiveness of surgical treatment for hemorrhoidal disease in patients with inflammatory bowel disease (IBD) is currently poorly supported by evidence. However, cautious surgical management of non-responsive CD patients with inactive disease is still recommended, though further studies are needed to assess the potential benefits of non-excisional techniques in this population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Surgery
Shannon N. Radomski, Miloslawa Stem, Michael Consul, Jay Rammohan Maturi, Haniee Chung, Susan Gearhart, Ada Graham, Vincent J. Obias
Summary: Research shows that the use of robotic surgical approaches in the management of inflammatory bowel disease (IBD) is increasing and is as safe as laparoscopic surgery. For patients with ulcerative colitis (UC), there is no difference in overall morbidity, serious morbidity, or conversion to open surgery between robotic and laparoscopic approaches. However, for patients with Crohn's disease (CD), the robotic approach has similar overall morbidity but higher rates of serious morbidity, shorter length of stay, and lower conversion rates to open surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Joao A. Cunha Neves, Joana Roseira, Patricia Queiros, Helena Tavares Sousa, Gianluca Pellino, Miguel F. Cunha
Summary: In this interventional study, sustainability measures were applied to achieve reduction of regulated medical waste and daily recycling in endoscopy practice, without compromising productivity.
Review
Gastroenterology & Hepatology
Shaji Sebastian, Jonathan P. Segal, Charlotte Hedin, Gianluca Pellino, Paulo Gustavo Kotze, Michel Adamina, Marjo Campmans-Kuijpers, Justin Davies, Annemarie C. de Vries, Ana Gutierrez Casbas, Alaa El-Hussuna, Pascal Juillerat, Susanna Meade, Monica Millan, Antonino Spinelli
Summary: This article provides expert consensus practice recommendations for peri-operative care in patients with inflammatory bowel diseases (IBD) to optimize surgical outcomes.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Surgery
Giuseppe S. Sica, Danilo Vinci, Leandro Siragusa, Bruno Sensi, Andrea M. Guida, Vittoria Bellato, Alvaro Garcia-Granero, Gianluca Pellino
Summary: This study aimed to assess the variations in definition and reporting of radical right colectomy (RRC). The results showed significant heterogeneity and overlap among different RRC techniques, which may jeopardize the interpretation of study outcomes. Consistent use of definitions and reporting of procedures is crucial for obtaining reliable conclusions in future trials.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Correction
Surgery
Francesco Pata, Marcello Di Martino, Mauro Podda, Salomone Di Saverio, Benedetto Ielpo, Gianluca Pellino
WORLD JOURNAL OF SURGERY
(2023)
Letter
Surgery
Francesco Pata, Marcello Di Martino, Salomone Di Saverio, Benedetto Ielpo, Gianluca Pellino
WORLD JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Valerio Celentano, Henna Rafique, Melanie Jerome, Yu Jin Lee, Christos Kontovounisious, Oliver Warren, Alexander MacDonald, Mahmood Wahed, Sarah Mills, Paris Tekkis
Summary: This study presents an institutional initiative to promote standardisation of multidisciplinary care in IPAA surgery, and proposes outcome measures that hope to support a subspecialty IPAA service.
FRONTLINE GASTROENTEROLOGY
(2023)
Letter
Gastroenterology & Hepatology
Matteo Rottoli, Alice Gori, Gianluca Pellino, Maria Elena Flacco, Antonino Spinelli, Gilberto Poggioli
Correction
Gastroenterology & Hepatology
V. Celentano, R. Beable, C. Ball, K. G. Flashman, R. Reeve, C. Fogg, M. Harper, A. Higginson
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Review
Gastroenterology & Hepatology
Leandro Siragusa, Gianluca Pellino, Bruno Sensi, Yves Panis, Vittoria Bellato, Jim Khan, Giuseppe S. S. Sica
Summary: This systematic review evaluates the feasibility, safety, and outcomes of ambulatory laparoscopic colectomy (ALC). The study shows that ALC is a safe and feasible option for selected patients with a high success rate and a low risk of readmission after discharge.
COLORECTAL DISEASE
(2023)
Review
Gastroenterology & Hepatology
A. Spinelli, F. M. Carrano, M. E. Laino, M. Andreozzi, G. Koleth, C. Hassan, A. Repici, M. Chand, V. Savevski, G. Pellino
Summary: Artificial intelligence has the potential to revolutionize surgery in the coming years. This review assessed the role of AI in colorectal surgery and identified various potential applications in the preoperative, intraoperative, and postoperative phases. However, more research is needed as AI in colorectal surgery is still in its early stages.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Emergency Medicine
Lorenzo Cobianchi, Francesca Dal Mas, Vanni Agnoletti, Luca Ansaloni, Walter Biffl, Giovanni Butturini, Stefano Campostrini, Fausto Catena, Stefano Denicolai, Paola Fugazzola, Jacopo Martellucci, Maurizio Massaro, Pietro Previtali, Federico Ruta, Alessandro Venturi, Sarah Woltz, Haytham M. Kaafarani, Tyler J. Loftus, Team Dynamics Study Grp
Summary: This study explores the understanding, barriers, and facilitators of shared decision-making (SDM) in trauma and emergency surgery. Findings show that less than half of the surgeons understand SDM and 30% still see value in exclusively engaging multidisciplinary provider teams without involving the patient. The inclusion of SDM practices in clinical guidelines is recommended.
WORLD JOURNAL OF EMERGENCY SURGERY
(2023)
Article
Gastroenterology & Hepatology
Valerio Celentano, Carlo Alberto Manzo
Summary: Appropriate patient selection, standardized surgical technique, and postoperative follow-up are essential for successful ileoanal pouch surgery. This study demonstrated a structured approach to laparoscopic proctectomy with ileoanal pouch anastomosis formation. Out of 38 patients, all procedures were completed laparoscopically, with a conversion rate of 2.6% to open surgery. There were postoperative complications in 34.2% of patients, with 15.8% classified as Clavien Dindo class 3 or higher. The stepwise approach resulted in a median bowel movement frequency of 4 per day at 12 months post-surgery.
COLORECTAL DISEASE
(2023)
Article
Surgery
Zoe Garoufalia, Gianluca Pellino
Summary: Social media has become an integral part of surgical communication, research, and patient education. It has revolutionized how academic congresses are held and provides benefits such as disseminating content and increasing engagement. However, it also has disadvantages including lack of content control, anonymity, and accuracy issues.
Review
Surgery
Francesco Pata, Bruno Nardo, Benedetto Ielpo, Marcello Di Martino, Valentina Murzi, Salomone Di Saverio, Baohong Yang, Monica Ortenzi, Adolfo Pisanu, Gianluca Pellino, Mauro Podda
Summary: This systematic review compared endoscopic retrograde appendicitis therapy with conventional treatment for appendicitis. The results showed no significant differences in technical success and treatment efficacy at one-year follow-up between the two approaches. However, endoscopic retrograde appendicitis therapy had advantages in terms of shorter procedural time and hospital stay.
Editorial Material
Surgery
Sameh Hany Emile, Nir Horesh, Michael Freund, Gianluca Pellino, Lucia Oliveira, Anjelli Wignakumar, Steven D. Wexner