Review
Immunology
Ping-Heng Tan, Jasmine Ji, Chun-Chang Yeh, Ru-Rong Ji
Summary: IFNs exert antiviral, antiproliferative, and immunomodulatory actions, with type-I IFNs like IFN-alpha and IFN-beta used in treating diseases such as hepatitis and multiple sclerosis. Emerging evidence indicates non-genomic regulation by IFN-alpha and IFN-beta in addition to canonical transcriptional regulations, leading to rapid suppression of neuronal activity and synaptic transmission. Type-I and type-II IFNs modulate pain and infection via neuro-immune interactions, with IFN-gamma inducing central sensitization and microglia activation in persistent pain. Insights into IFN signaling in nociceptors and their roles in distinct physiological vs. pathological conditions will enhance pain treatments after surgeries, traumas, and infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiang Chen, Shuqing Zhuang, Yilin Hong, Lingtao Yang, Peng Guo, Pingli Mo, Kesong Peng, Wengang Li, Nengming Xiao, Chundong Yu
Summary: The study found that PD-L1 and JMJD2D are frequently overexpressed in human CRC specimens and have a significant positive correlation. Knocking out JMJD2D in CRC cells weakens the expression of PD-L1, inhibits tumor growth, and increases the number and function of CD8(+) T cells in tumor infiltration. JMJD2D promotes the expression of PD-L1 by co-activating SP-1 to promote the expression of IFNGR1, thereby enhancing STAT3-IRF1 signaling. Pharmacological inhibition of JMJD2D can improve the therapeutic effect of PD-L1 antibody, increase the infiltration and function of CD8(+) T cells.
Article
Oncology
Lijuan Sun, Tim Kees, Ana Almeida, Bodu Liu, Xue-Yan He, David Ng, Xiao Han, David Spector, Iain McNeish, Phyllis Gimotty, Sylvia Adams, Mikala Egeblad
Summary: The combination of MPLA and IFNγ can polarize tumor-associated macrophages to kill cancer cells, reducing primary tumor growth and metastasis. This approach also enhances chemotherapy response and suppresses metastasis, with both macrophages and T cells playing critical roles in the anti-metastatic effects. Engaging a systemic anti-tumor immune response through activation of macrophages and T cells may represent a promising strategy for cancer treatment.
Article
Immunology
Elisa Petruccioli, Linda Petrone, Teresa Chiacchio, Chiara Farroni, Gilda Cuzzi, Assunta Navarra, Valentina Vanini, Umberto Massafra, Marianna Lo Pizzo, Giuliana Guggino, Nadia Caccamo, Fabrizio Cantini, Fabrizio Palmieri, Delia Goletti
Summary: Patients with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have a higher risk of developing active tuberculosis (TB) compared to the general population. Studying the M. tuberculosis (Mtb) specific T-cell response may help identify immune biomarkers of Mtb burden or clearance in different TB statuses and risk groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Multidisciplinary Sciences
Johanna M. Schafer, Tong Xiao, Hyunwoo Kwon, Katharine Collier, Yuzhou Chang, Hany Abdel-Hafiz, Chelsea Bolyard, Dongjun Chung, Yuanquan Yang, Debasish Sundi, Qin Ma, Dan Theodorescu, Xue Li, Zihai Li
Summary: This article explains the reasons behind higher incidence and mortality rates for males in non-reproductive system cancers, focusing on the role of sex chromosomes and sex hormones in driving differential adaptive immunity. The article highlights the involvement of cell-intrinsic androgen receptors in CD8(+) T cell dysfunction or exhaustion in the tumor microenvironment, and summarizes ongoing clinical efforts to investigate the impact of androgen blockade on cancer immunotherapy. It emphasizes the importance of a comprehensive research approach to understanding sex dimorphisms in cancer and advocating for considering sex as a crucial factor in guiding treatment decisions in the future.
Article
Oncology
Antoni Ribas, W. Nicholas Haining, Ton N. M. Schumacher
Summary: Tumor-specific cytotoxic T cells need to change the tumor microenvironment to enhance their antitumor effects. IFN-γ plays a critical role by altering the gene expression of cancer cells and immune cells, turning them into enablers of the antitumor immune response.
Article
Oncology
Brian J. Park, Austin K. Mattox, Daniel Clayburgh, Mihir Patel, R. Bryan Bell, Bevan Yueh, Rom Leidner, Hong Xiao, Marcus Couey, Shiting Li, Tingting Qin, Maureen A. Sartor, Belinda Cairns, Tracy MacDonough, Kyle Halliwill, Daniel Deschler, Derrick T. Lin, William C. Faquin, Peter M. Sadow, Sara Pai
Summary: PD-L1 testing is important for decision-making in HNSCC treatment. Chemoradiation therapy has a significant impact on PD-L1 expression, especially when using a cut-off of CPS >= 20 and >= 50. Oral cavity cancer shows higher discordance rates in local and regional recurrence, suggesting the need for repeat biopsy.
Article
Biochemistry & Molecular Biology
Yuyin Zheng, Lanxin Hu, Yuwen Yang, Cheng Zheng, Wenzhan Tu, Haiyan Lin, Haotian Wang, Yiwei Jiang, Songhe Jiang, Wu Zheng
Summary: This study identified the critical role of IFN-gamma signaling in the choroid plexus (CP) in the pathological process of experimental autoimmune encephalomyelitis (EAE). Blocking the IFN-gamma signal by knocking down IFN-gamma R1 in the CP protected mice against EAE pathology, as evidenced by improvements in clinical scores and infiltration. The study also revealed that IFN-gamma signaling in the CP may participate in the pathological process of EAE by preventing pathological Th17+ cells from infiltrating into the CNS.
Article
Immunology
Audrey Lee, Katharine Floyd, Shengyang Wu, Zhuoqing Fang, Tze Kai Tan, Heather M. Froggatt, John M. Powers, Sarah R. Leist, Kendra L. Gully, Miranda L. Hubbard, Chunfeng Li, Harold Hui, David Scoville, Alistaire D. Ruggiero, Yan Liang, Anna Pavenko, Victor Lujan, Ralph S. Baric, Garry P. Nolan, Prabhu S. Arunachalam, Mehul S. Suthar, Bali Pulendran
Summary: The study reveals the mechanisms underlying the nonspecific antiviral effects exerted by the BCG vaccine against SARS-CoV-2 and highlights the pivotal role of BCG-specific CD4+ T cells in imprinting a persistent antiviral innate program in the lung, mediating heterologous viral protection.
Article
Immunology
Shanmuga Sundaram Mahalingam, Sangeetha Jayaraman, Adhvika Arunkumar, Holly M. Dudley, Donald D. Anthony, Carey L. Shive, Jeffrey M. Jacobson, Pushpa Pandiyan
Summary: Individuals aged >61 show intrinsic changes in T cell responses during SARS-CoV-2 infection, including reduced cytokine production capacity and increased PD-1(+) cells. These findings may provide insights into dysregulated immune responses in COVID-19 in the elderly.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Wenxiu Chen, Yiting Hua, Conghui Shan, Jia Wei, Yutong Zhou, Shiyang Pan
Summary: This study investigated reliable markers based on circulating immune cell subsets to predict the curative effect of PD-1 antibody treatment in patients with non-small cell lung cancer (NSCLC). The percentage of circulating PD-1(+)IFN-gamma(+) subset of CD8(+) T cell was found to be a potential marker at baseline to predict early response or progression in NSCLC patients receiving chemotherapy combined with anti-PD-1 therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Marius Schwabenland, Omar Mossad, Annika Sievert, Adam G. Peres, Elena Ringel, Sebastian Baasch, Julia Kolter, Giulia Cascone, Nikolaos Dokalis, Andreas Vlachos, Zsolt Ruzsics, Philipp Henneke, Marco Prinz, Thomas Blank
Summary: The study found that mimicking early systemic viral infection in neonatal mice resulted in behavioral deficits and immune response changes only in male adolescent mice, while female mice were unaffected. This suggests that there may be sex-dependent differences in the susceptibility and long-term effects of CNS disorders following early life immune activation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Baohuan Cai, Yun Liu, Yating Chong, Hualei Zhang, Atsuko Matsunaga, Xuexiu Fang, Rafal Pacholczyk, Gang Zhou, John K. Cowell, Tianxiang Hu
Summary: The study revealed that IRAK1 orchestrates an immune escape mechanism by regulating the IFN-γ signaling in leukemia cells to induce the generation of MDSCs in SCLL. The knockout of IRAK1 using CRISPR technology can suppress leukemia cell growth and inhibit disease progression by restoring immune surveillance.
Article
Biotechnology & Applied Microbiology
Mikal El-Hajjar, Lara Gerhardt, Megan M. Y. Hong, Mithunah Krishnamoorthy, Rene Figueredo, Xiufen Zheng, James Koropatnick, Saman Maleki Vareki
Summary: Immune checkpoint blockade is effective against highly immunogenic mismatch repair-deficient tumors but not neuroblastoma. However, stimulating T cell-based therapy and memory T cell-dependent gene expression can improve survival in high-risk neuroblastoma patients. Inducing mismatch repair deficiency and combining it with anti-CTLA4 therapy can serve as a novel T cell-based treatment strategy for neuroblastoma.
Article
Immunology
Xuyang Wang, Liqiu Jia, Yang Liu, Jing Wang, Chao Qiu, Tao Li, Wenhong Zhang, Zhaoqin Zhu, Jing Wu, Yanmin Wan
Summary: Individuals with IL12RB1 deficiency are more susceptible to BCG and environmental mycobacteria infections. This study using a mouse model reveals that IL12RB1-deficient mice have impaired tuberculosis suppression, with decreased innate immune responses and increased IL-17 responses. It suggests that IFN-gamma responses alone may not be sufficient to contain BCG infection in the setting of IL12RB1 deficiency.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)