Review
Nanoscience & Nanotechnology
Jianhua Zou, Ling Li, Zhen Yang, Xiaoyuan Chen
Summary: Phototherapy combined with immunotherapy enhances the immunostimulating response and has synergistic effects for cancer treatment. Photoimmunotherapy (PIT) is a potential win-win strategy to prevent tumor metastases and recurrence by inducing immunogenic cell death (ICD).
Review
Biochemistry & Molecular Biology
Banendu Sunder Dash, Gils Jose, Yu-Jen Lu, Jyh-Ping Chen
Summary: Nanomedicine using carbon-based nanomaterials, especially reduced graphene oxide (rGO), has shown promising potential in cancer therapy due to its ability to carry drugs and act as a photothermal agent. Functionalized rGO can be designed as multifunctional nanosystems with temperature/pH-dependent drug/gene delivery abilities for multimodal cancer therapy. Additional advantages like high biocompatibility, targeted delivery, and enhanced photothermal effects further enhance the potential of functionalized rGO in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Bei Li, Xiaoya Niu, Maodi Xie, Fan Luo, Xiuyi Huang, Zhen You
Summary: This study developed a multifunctional nanoprobe with excellent therapeutic outcomes and tumor-targeting characteristics, demonstrating its potential in the treatment of tumors.
Review
Nanoscience & Nanotechnology
Cunqing Kong, Xingcai Chen
Summary: This article summarizes the importance and development of photoactivation therapy based on photodynamic therapy (PDT) and photothermal therapy (PTT) in tumor treatment. Photosensitizers and photothermal conversion agents play a key role in the phototherapy process. The advancement of nanotechnology has promoted the application of phototherapy in tumor treatment. PDT can increase the sensitivity of tumor cells to PTT, while PTT can enhance the therapeutic effect of PDT.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Polymer Science
Pedro D. Fernandes, Fernao D. Magalhaes, Ruben F. Pereira, Artur M. Pinto
Summary: Conventional cancer therapies have long-term side effects, while phototherapy and immunotherapy offer alternative treatments with different merits. Metal-organic frameworks (MOFs) have shown significant potential in the fields of cancer phototherapy and immunotherapy due to their unique properties. By addressing the drawbacks of current therapies, MOF nanoplatforms enable effective and low-side-effect combinatorial synergistical treatment for cancer.
Review
Chemistry, Multidisciplinary
Jiayan Wu, Kanyi Pu
Summary: Semiconducting polymer nanoparticles (SPNs) have been widely used in tumor treatment. Through modification, SPNs can encapsulate or conjugate with various types of immune modulators. This review summarizes the recent progress of SPNs-based combination cancer immunotherapy and highlights the synergetic effect that amplifies the anti-tumor immune response.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Junjian Shen, Minghui Lin, Mengbin Ding, Ningyue Yu, Chun Yang, Deping Kong, Haitao Sun, Zongyu Xie
Summary: In this study, a novel tumor immunosuppressive microenvironment modulating hydrogel platform was developed for the safe, effective, and durable lung metastasis-inhibiting breast cancer treatment. The platform achieved second NIR-II photothermal therapy combined with immunotherapy, prolonging the accumulation time and preventing premature release of immunotherapeutic agents. The platform elevated intratumoral temperature, induced tumor cell apoptosis, and activated thermal immune response by regulating the immunosuppressive microenvironment.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Feifan Zhou, Meng Wang, Teng Luo, Junle Qu, Wei R. Chen
Summary: By combining photothermal therapy, chemotherapy, and immunotherapy through a nanosystem, researchers developed a treatment strategy that not only destroyed local tumors and inhibited distant metastases in mouse models but also induced long-term survivors with tumor type-specific immunity. This synergistic approach showed potential for treating metastatic cancers by inducing a systemic antitumor response through a local intervention.
Article
Chemistry, Multidisciplinary
Weiwei Wu, Yan Yang, Zhuoying Liang, Xiling Song, Yadong Huang, Lin Qiu, Xiaozhong Qiu, Siming Yu, Wei Xue
Summary: This study demonstrated the effective strategy of utilizing near-infrared laser-induced simultaneous release of NO and alkyl radicals to inhibit tumor growth, achieved through the elaborately fabricated biocompatible free radical nanogenerator. Under NIR II laser irradiation, the nanogenerator can precisely control the release profiles of NO and alkyl radicals, displaying synergistic anticancer effects on breast tumors.
Review
Chemistry, Inorganic & Nuclear
Carlos F. G. C. Geraldes, M. Margarida C. A. Castro, Joop A. Peters
Summary: Mn(III) porphyrins show great potential as Gd-free MRI contrast agents due to their interesting redox properties and high affinity for tumor tissues. With applications in photothermal, photodynamic, and sonodynamic therapies, they are attractive for theranostics development. Their relative longitudinal relaxivity at typical clinical MRI field strengths is even higher than traditional Gd-based agents.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Instruments & Instrumentation
Vahid Alimardani, Samira Sadat Abolmaali, Ali Mohammad Tamaddon, Mohammad Ashfaq
Summary: Microneedles arrays (MNs) have been introduced as a novel, minimally invasive, and low-cost approach to deliver drugs to tumor tissues in a safe and controlled manner. They have promising potential in cancer therapy applications.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Wei Gao, Weihao Zhang, Haipeng Yu, Wenge Xing, Xueling Yang, Yongguang Zhang, Chunyong Liang
Summary: MXene nanosheets have the potential for use in nanomedicine due to their large surface area, near-infrared absorbance, and biocompatibility. However, their application in tumor treatment is limited by current design methodologies. This study presents a simple strategy to process MXene with carbon nanotubes into a three-dimensional honeycomb structure that can be used in disease phototherapy. The structure exhibits special photothermal effects and stability, effectively inhibiting tumor cell proliferation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carlota M. Relvas, Susana G. Santos, Maria J. Oliveira, Fernao D. Magalhaes, Artur M. Pinto
Summary: Skin cancer is a common and increasing type of cancer with two main categories: melanoma and non-melanoma. Current treatments, including surgery, radiation therapy, and chemotherapy, have limitations in terms of mortality and recurrence rates. Recent studies have focused on new approaches, such as immunotherapy and various forms of phototherapy. Among these, photoimmunotherapy has gained attention for its potential outcomes in combining photodynamic and/or photothermal therapy with a systemic immune response. This review critically discusses the properties and mechanisms of action of different nanomaterials in skin cancer photoimmunotherapy and presents important results in the field.
Review
Chemistry, Multidisciplinary
Yao Xiong, Yan Rao, Jiawei Hu, Zixuan Luo, Chuang Chen
Summary: Photothermal therapy (PTT) combined with nanotechnology has emerged as a promising noninvasive treatment strategy for breast cancer. This comprehensive review explores the use of various nanoparticles in PTT for breast cancer, highlighting their specific roles and mechanisms of action. The integration of PTT with existing clinical therapies and the modifications to the tumor microenvironment are also discussed.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Jun Zhou, Chen Cao, Xinlu Zhang, Xu Zhang, Jiansen Li, Hongzhang Deng, Sheng Wang
Summary: Phototherapies have made significant progress in cancer treatment, but face challenges. Gas therapy, which improves the level of specific gas at the tumor site, shows potential to overcome these challenges. Nanomedicine-based gas-assisted phototherapy has emerged as a promising strategy to enhance treatment efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)