Article
Infectious Diseases
Sebastian G. Wicha, Andrea Mair, Ute Chiriac, Otto R. Frey, Thomas Fuchs, Max Gaasch, Stefan Hagel, Daniel C. Richter, Jason A. Roberts, Anka C. Roehr, Markus A. Weigand, Alexander Brinkmann
Summary: This study described the pharmacokinetic characteristics of continuous infusion of linezolid in critically ill patients and established the relationship between linezolid exposure and platelet count over time. It suggested that optimizing linezolid dosing based on creatinine clearance and body weight can maximize therapeutic exposures and that therapeutic drug monitoring may be necessary due to high variability in individual doses.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Microbiology
Mei Yang, Libo Zhao, Xiaohui Wang, Chen Sun, Hengmiao Gao, Xiaoling Wang, Suyun Qian
Summary: This study evaluated the population pharmacokinetic properties of linezolid in critically ill children and established an optimal dosage regimen based on developmental PopPK/PD model and simulation. Factors such as body weight and AST levels were found to significantly affect the variability in linezolid pharmacokinetics in the pediatric population. Dosage adjustment according to AST levels was deemed necessary for treatment success.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Medicine, General & Internal
Anna S. Messmer, Tatjana Dill, Martin Muller, Carmen A. Pfortmueller
Summary: This study included 13 trials, and found that active fluid de-resuscitation measures had no significant impact on short-term mortality, fluid separation, or patient-centered outcomes in patients with septic shock. The current evidence is limited by the lack of high-quality trials, small sample sizes, and heterogeneity of de-resuscitation techniques.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Fan Wu, Xiao-Shan Zhang, Ying Dai, Zi-Ye Zhou, Chun-Hong Zhang, Lu Han, Fang-Min Xu, Ye-Xuan Wang, Da-Wei Shi, Guan-Yang Lin, Xu-Ben Yu, Fang Chen
Summary: This study aimed to determine the pharmacokinetic/toxicodynamic threshold for linezolid treatment in critically ill patients and propose a dosing strategy for patients with renal insufficiency.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Alison L. Blackman, Praneeth Jarugula, David P. Nicolau, Sai Ho Chui, Manjari Joshi, Emily L. Heil, Mathangi Gopalakrishnan
Summary: This study demonstrates that standard linezolid doses may not be adequate for all patients, especially for noncirrhotic patients weighing over 140 kg with minimum inhibitory concentrations of >= 2mg/liter, as target attainment of >= 90% is not achieved in this population.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Xiao-bin Lin, Xiao-guang Hu, Zhao-xia Tang, Peng-hao Guo, Xiao-man Liu, Tao Liang, Yan-zhe Xia, Ka Yin Lui, Pan Chen, Ke-jing Tang, Xiao Chen, Chang-jie Cai
Summary: This prospective study aimed to describe the pharmacokinetics of intravenous VRC in the peritoneal fluid of critically ill patients. The VRC concentrations in peritoneal fluid showed a slower rise and lower fluctuation than in plasma. Good but variable penetration of VRC into the peritoneal cavity was observed, with median peritoneal fluid/plasma ratios of 0.54 and 0.67 for single and multiple doses, respectively.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Qian Liu, Sanwang Li, Feifan Xie
Summary: This study aimed to provide a population PK analysis of linezolid in patients undergoing renal replacement therapy (RRT), and evaluate the target attainment of linezolid standard dosing. The results showed that standard linezolid dosing is adequate for anuric RRT patients with MIC <= 2 mg/L. The probability of target attainment was low for RRT patients with preserved renal function.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Infectious Diseases
Ligia-Ancuta Hui, Constantin Bodolea, Laurian Vlase, Elisabeta Ioana Hiriscau, Adina Popa
Summary: A judicious antibiotic therapy is essential for critically ill patients with sepsis and septic shock. Understanding the pharmacokinetics and pharmacodynamics of antibiotics, particularly linezolid, is crucial for achieving therapeutic goals and minimizing side effects in intensive care settings.
Article
Nutrition & Dietetics
Hongxing Dang, Jing Li, Chengjun Liu, Feng Xu
Summary: This study investigated the prevalence of vitamin E deficiency in critically ill children with sepsis, finding a higher incidence in the infection group and septic shock subgroup. Vitamin E deficiency was associated with higher mortality rates in critically ill children and showed an independent effect on septic shock.
FRONTIERS IN NUTRITION
(2021)
Article
Hematology
Won Kyoung Jhang, Seong Jong Park
Summary: The modified SIC score for critically ill children with septic shock showed good ability to predict 28-day mortality and was identified as an independent prognostic factor. It demonstrated better performance in predicting clinical outcomes compared to other diagnostic scoring systems.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Infectious Diseases
Lu Shi, Ying Zhang, Lufen Duan, Lifeng Huang, Jingjing Li, Jian Lu, Zhiwei Zhuang, Yunlong Yuan, Zongtai Feng, Jiantong Sun, Xin Liu, Qin Zhou, Hongzhi Xue, Jinhui Xu, Lian Tang
Summary: This study evaluated the effect of clinical pharmacist-mediated optimisation of a linezolid regimen using a population pharmacokinetic (PPK) model. The results showed that interventions by clinical pharmacists reduced the incidence of linezolid-induced thrombocytopenia (LIT) and other adverse drug reactions (ADRs). Furthermore, implementation of model-informed precision dosing (MIPD) for linezolid markedly increased the proportion of patients with target trough concentration (Cmin) and area under the concentration-time curve/MIC ratio (AUC24/MIC).
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Public, Environmental & Occupational Health
Shanshan Jin, Jian Luo, Xiayun Wu, Danqiong Wang, Weiwen Zhang, Zhangping Li
Summary: The Omicron variant infection can cause severe symptoms, but active rescue treatment combining Chinese and Western medicine can effectively control the clinical symptoms.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Daniele Roberto Giacobbe, Francesca Crea, Paola Morici, Laura Magnasco, Vincenzo Di Pilato, Federica Briano, Edward Willison, Rachele Pincino, Silvia Dettori, Stefania Tutino, Simone Esposito, Erika Coppo, Chiara Dentone, Federica Portunato, Malgorzata Mikulska, Chiara Robba, Antonio Vena, Denise Battaglini, Iole Brunetti, Lorenzo Ball, Paolo Pelosi, Anna Marchese, Matteo Bassetti
Summary: This retrospective study analyzed the impact of T2Bacteria and T2Resistance tests on the diagnosis and treatment of sepsis in critically ill patients. The results showed that these tests can help identify causative agents and resistance determinants in advance and influence treatment decisions.
Review
Microbiology
Katherine Elizabeth Bline, Mark W. Hall
Summary: The inflammatory response in pediatric sepsis is dynamic, involving both pro- and anti-inflammatory elements that can lead to acquired immunodeficiency. This review focuses on the pathophysiology and clinical implications of immune dysfunction in septic children, including risk factors for immunoparalysis and immunomodulation strategies currently under clinical trials.
Review
Medicine, General & Internal
Salvatore Lucio Cutuli, Simone Carelli, Domenico Luca Grieco, Gennaro De Pascale
Summary: Sepsis is a condition triggered by infection-induced immune alterations and can theoretically be improved through pharmacological or extracorporeal immune modulation therapies. While pharmacological immune modulation may have long-lasting effects, extracorporeal immune modulation allows for short-term removal of inflammatory mediators from the bloodstream. Despite the widespread use of these therapies in clinical practice, their specific role in critically ill septic patients remains unclear.
MEDICINA-LITHUANIA
(2021)
Article
Critical Care Medicine
Fei Peng, Chenglong Liang, Wei Chang, Qin Sun, Jianfeng Xie, Haibo Qiu, Yi Yang
Summary: Elevated plasma HGF levels in sepsis patients are associated with poor prognosis and correlated with established markers of endothelial cell injury, indicating their potential as an efficient indicator for outcome prediction in septic patients.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Engineering, Biomedical
Chenglong Li, Tong Cai, Haixiu Xie, Liangshan Wang, Feng Yang, Zhongtao Du, Xiaoyang Hong, Chengbing Zhou, Yimin Li, Haibo Qiu, Zhaohui Tong, Hui Zeng, Zhiyong Peng, Xin Li, Xiaotong Hou
Summary: This study analyzed the occurrence, risk factors, and clinical outcomes of bleeding complications in patients supported with extracorporeal membrane oxygenation (ECMO). The results showed that 18.1% of ECMO patients in the Chinese Society of Extracorporeal Life Support (CSECLS) registry experienced bleeding complications, which were associated with higher in-hospital mortality, especially in patients who received extracorporeal cardiopulmonary resuscitation (ECPR), patients on circulatory support, and pediatric patients.
Letter
Medicine, General & Internal
Xian Qi, Haibo Qiu, Shixuan Hao, Fengcai Zhu, Yingzi Huang, Ke Xu, Huiyan Yu, Daowei Wang, Lei Zhou, Qigang Dai, Yin Zhou, Shenjiao Wang, Haodi Huang, Shuyue Yu, Xiang Huo, Kai Chen, Jin Liu, Jianli Hu, Ming Wu, Changjun Bao
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cell & Tissue Engineering
Ming Xue, Xiwen Zhang, Jianxiao Chen, Feng Liu, Jingyuan Xu, Jianfeng Xie, Yi Yang, Weiping Yu, Haibo Qiu
Summary: This study found that under hypoxic and inflammatory conditions, the transforming growth factor-β1 (TGF-β1) secreted by mesenchymal stem cells (MSCs) can regulate the Treg/Th17 skewing induced by lipopolysaccharide (LPS) and hypoxia by inhibiting the expression of miR-155. These findings provide evidence for future T lymphocyte-targeted cell therapy in specific conditions.
STEM CELLS INTERNATIONAL
(2022)
Letter
Critical Care Medicine
Dongyu Chen, Leo Heunks, Chun Pan, Jianfeng Xie, Haibo Qiu, Yi Yang, Ling Liu
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Correction
Cell & Tissue Engineering
Feng Liu, Jianfeng Xie, Xiwen Zhang, Zongsheng Wu, Shi Zhang, Ming Xue, Jianxiao Chen, Yi Yang, Haibo Qiu
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Chun Pan, Hui Chen, Jianfeng Xie, Yingzi Huang, Yi Yang, Bin Du, Haibo Qiu
Summary: Convalescent plasma therapy can improve the negative conversion rate of SARS-CoV-2 but does not improve the 60-day mortality in patients with severe and life-threatening COVID-19 infection.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Le Zhang, Yuxing Wang, Chang Cao, Yike Zhu, Wei Huang, Yi Yang, Haibo Qiu, Songqiao Liu, Dayong Wang
Summary: In this study, the potential of Xuebijing treatment against bacterial infection and the underlying mechanisms were investigated using Caenorhabditis elegans as an animal model. The results showed that Xuebijing could inhibit the reduction of lifespan caused by Pseudomonas aeruginosa infection by inhibiting colonization of the bacteria in the intestinal lumen. Xuebijing treatment also suppressed the increase in antimicrobial gene expression induced by Pseudomonas infection.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Linhui Hu, Haibo Qiu, Ling Liu, Claude Guerin, Chunbo Chen
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Alexis Tabah, Niccolo Buetti, Quentin Staiquly, Stephane Ruckly, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Andrew Conway Morris, Matteo Bassetti, Kostoula Arvaniti, Jeffrey Lipman, Ricard Ferrer, Haibo Qiu, Jose-Artur Paiva, Pedro Povoa, Liesbet De Bus, Jan De Waele, Farid Zand, Mohan Gurjar, Adel Alsisi, Khalid Abidi, Hendrik Bracht, Yoshiro Hayashi, Kyeongman Jeon, Muhammed Elhadi, Francois Barbier, Jean-Francois Timsit
Summary: This study investigated hospital-acquired bloodstream infections (HA-BSI) in 2600 adult patients from 333 ICUs in 52 countries. HA-BSI were frequently caused by Gram-negative, carbapenem-resistant, and difficult-to-treat pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy, resulting in high mortality rates.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Songqiao Liu, Chen Yao, Jianfeng Xie, Hong Liu, Hongliang Wang, Zhaofen Lin, Bingyu Qin, Difen Wang, Weihua Lu, Xiaochun Ma, Yan Liu, Ling Liu, Chi Zhang, Lei Xu, Ruiqiang Zheng, Feihu Zhou, Zhongmin Liu, Guoqiang Zhang, Lixin Zhou, Jian Liu, Aihua Fei, Guoxiu Zhang, Yimin Zhu, Kejian Qian, Ruilan Wang, Yafeng Liang, Meili Duan, Dawei Wu, Rongqing Sun, Ying Wang, Xijing Zhang, Quan Cao, Mingshi Yang, Minggen Jin, Yan Song, Ling Huang, Fachun Zhou, Dechang Chen, Qun Liang, Chuanyun Qian, Zhongzhi Tang, Zhong Zhang, Qiming Feng, Zhiyong Peng, Renhua Sun, Zhenju Song, Yunbo Sun, Yanfen Chai, Lihua Zhou, Chen Cheng, Li Li, Xiaoyan Yan, Junhua Zhang, Yingzi Huang, Fengmei Guo, Chuan Li, Yi Yang, Hongcai Shang, Haibo Qiu, EXIT-SEP Investigators
Summary: In this multicenter, randomized double-blind, placebo-controlled trial, the administration of XBJ was found to reduce 28-day mortality among patients with sepsis.
JAMA INTERNAL MEDICINE
(2023)
Article
Critical Care Medicine
Hui Chen, Qin Sun, Yali Chao, Yue Liu, Qian Yu, Jianfeng Xie, Chun Pan, Ling Liu, Yi Yang, Haibo Qiu
Summary: The association between ventilator variables and mortality varies among ARDS patients with different lung morphology. A novel ventilator variable (4xDP + RR) is found to have significant impact on mortality in ARDS patients, but further validation is needed.
Article
Critical Care Medicine
Hui Chen, Qian Yu, Jianfeng Xie, Songqiao Liu, Chun Pan, Ling Liu, Yingzi Huang, Fengmei Guo, Haibo Qiu, Yi Yang
Summary: This study successfully identified three novel longitudinal phenotypes for ARDS patients using 24-hourly data from the first four days of invasive ventilation. These phenotypes were validated in four clinical trials, and simple classifier models were constructed for accurate identification.
Letter
Critical Care Medicine
Ling Liu, Jianfeng Xie, Changsong Wang, Zhanqi Zhao, Yang Chong, Xueyan Yuan, Haibo Qiu, Mingyan Zhao, Yi Yang, Arthur S. Slutsky
Article
Medicine, General & Internal
Shanshan Meng, Feiping Xia, Jingyuan Xu, Xiwen Zhang, Ming Xue, Mingyuan Gu, Fengmei Guo, Yingzi Huang, Haibo Qiu, Yi Yang
Summary: Pulmonary microvascular endothelial cells play a crucial role in the pathogenesis of acute lung injury. This study demonstrated that hepatocyte growth factor (HGF) protects the endothelium by suppressing oxidative stress and mitochondria-dependent apoptosis, thereby maintaining the integrity of the endothelial barrier. The mTOR/STAT3 signaling pathway was found to be involved in these protective effects.
CHINESE MEDICAL JOURNAL
(2022)