Article
Oncology
Eunice Eugenia Robless, Justin Andrew Howard, Ilaria Casari, Marco Falasca
Summary: Extracellular vesicles, particularly exosomes, are key players in intercellular communication, with a specific focus on their role in pancreatic cancer. Long non-coding RNAs (lncRNAs) within these vesicles are of increasing interest as potential biomarkers and therapeutic targets for pancreatic cancer, yet their precise functions within cancer exosomes remain unclear.
Article
Oncology
Bingxian Bian, Li Li, Xing Ke, Hui Chen, Yi Liu, Naisheng Zheng, Yingxia Zheng, Yanhui Ma, Yunlan Zhou, Junyao Yang, Lanshu Xiao, Lisong Shen
Summary: Urinary exosomal long non-coding RNAs have been identified as potential noninvasive biomarkers for the diagnosis of bladder cancer through high-throughput RNA sequencing. A panel of genes has been established for the diagnosis of bladder cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Jianjun Wang, Yujie Li, Nan Wang, Jianhong Wu, Xiaojian Ye, Yibiao Jiang, Lijun Tang
Summary: Tuberculosis (TB) is a fatal bacterial contagious disease caused by Mycobacterium tuberculosis (M. tb), and recent studies suggest that exosomes could be a novel option for TB diagnosis and treatment. Exosomes are nanovesicles (30-150 nm) released from various cells, carrying lipids, proteins, and non-coding RNAs (ncRNAs), and they play a role in cell-to-cell communication. Exosomal ncRNAs have shown diagnostic potential in bacterial infections, including TB, and also regulate the functions of M. tb-infected cells, serving as diagnostic markers for TB. This review explores the biological roles and diagnostic application prospects of exosomal ncRNAs in TB, as well as their pathogenic and therapeutic functions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Yi Yi, Min Wu, Hong Zeng, Weijie Hu, Chongru Zhao, Mingchen Xiong, Wenchang Lv, Pei Deng, Qi Zhang, Yiping Wu
Summary: Breast cancer is the most common malignancy among women worldwide, and exosomal non-coding RNAs play significant regulatory roles in breast cancer cells, affecting angiogenesis, immunoregulation, proliferation, and migration.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Hui-Jin Li, Xue Gong, Zheng-Kun Li, Wei Qin, Chun-Xia He, Lu Xing, Xin Zhou, Dong Zhao, Hui-Ling Cao
Summary: Bladder cancer is characterized by dysregulated lncRNAs, which play key roles in tumorigenesis, progression, and prognosis. These lncRNAs can serve as potential diagnostic and prognostic biomarkers for bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nasim Ebrahimi, Ferdos Faghihkhorasani, Siavash Seifollahy Fakhr, Parichehr Roozbahani Moghaddam, Elnaz Yazdani, Zahra Kheradmand, Fatemeh Rezaei-Tazangi, Samaneh Adelian, Halimeh Mobarak, Michael R. Hamblin, Amir Reza Aref
Summary: Reliable, accessible, and non-invasive biomarkers are crucial for reducing cancer mortality. Extracellular vesicles, particularly exosomes, have emerged as potential biomarkers for the diagnosis and follow-up of solid and hematopoietic tumors due to their abundance in bodily fluids and ability to transport various biomolecules. However, the lack of standardized effective methods for their isolation, identification, and precise characterization poses challenges for their clinical application.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Yufei Yang, Xuebing Yan, Xinxiang Li, Yanlei Ma, Ajay Goel
Summary: Colorectal cancer is a common malignancy with challenges in diagnosis and treatment, and recent research suggests that long non-coding RNAs play important roles in the progression of the disease.
Article
Biochemistry & Molecular Biology
Qun Lin, Yu Shi, Zihao Liu, Maryam Mehrpour, Ahmed Hamai, Chang Gong
Summary: Recent research has shown that non-coding RNAs play crucial roles in regulating both selective and non-selective autophagy, with abnormal expression impacting autophagy and contributing to carcinogenesis. Understanding the regulatory roles of ncRNAs in autophagy may offer valuable therapeutic targets for cancer management.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Oncology
Mohammad Roshani, Ghazaleh Baniebrahimi, Mahboubeh Mousavi, Noushid Zare, Reza Sadeghi, Reza Salarinia, Amirhossein Sheida, Danial Molavizadeh, Sara Sadeghi, Farzaneh Moammer, Mohammad Reza Zolfaghari, Hamed Mirzaei
Summary: Exosomal lncRNAs play a crucial role in the biology of gastrointestinal cancer and can be utilized as biomarkers for diagnosis, prognosis, and potential treatment targets.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ohanes Ashekyan, Samira Abdallah, Ayman Al Shoukari, Ghada Chamandi, Hayat Choubassy, Abdul Rahman S. Itani, Nisreen Alwan, Rihab Nasr
Summary: Breast cancer is the most common cancer type worldwide, and metastatic disease is the main cause of death. Non-coding RNAs found in exosomes have been found to play important roles in breast cancer progression, drug sensitivity/resistance, and have the potential to be used as diagnostic, prognostic, and predictive biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Huiyuan Xiao, Wen Huang, Yanlei Li, Rongxin Zhang, Long Yang
Summary: The study showed that higher expression of TTN-AS1 was associated with poorer DFS in BC patients, especially in those who underwent Re-TURBT. Knocking down TTN-AS1 could inhibit the proliferation and invasion abilities of BC cells. ATF2 may act as a downstream target of TTN-AS1 in BC, and high expression of ATF2 is also related to adverse DFS in patients.
FRONTIERS IN GENETICS
(2021)
Review
Pharmacology & Pharmacy
Xingyu Gao, Haiying Zhang, Chang Zhang, Minghe Li, Xiao Yu, Yanan Sun, Yingai Shi, Hongxia Zhang, Xu He
Summary: This review summarizes the metabolic regulatory mechanisms of long non-coding RNAs (lncRNAs) in the progression of renal cell carcinoma (RCC), especially their roles in glucose metabolism, lipid metabolism, amino acid metabolism, and mitochondrial dynamics. It also discusses the clinical applications of lncRNAs targeting metabolism in RCC therapy. Accumulating evidence shows that lncRNAs participate in the occurrence and progression of RCC, achieved through the lncRNA-miRNA-mRNA axis. This study provides new targets and approaches for early clinical diagnosis, treatment, and prognosis of RCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Ebrahim Balandeh, Kimia Mohammadshafie, Yaser Mahmoudi, Mohammad Hossein Pourhanifeh, Ali Rajabi, Zahra Razaghi Bahabadi, Amir Hossein Mohammadi, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei
Summary: Non-coding RNAs play a crucial role in regulating angiogenesis in glioblastoma, affecting gene transcription and the expression of angiogenesis-inducing molecules through various mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Wenqi Ti, Jianbo Wang, Yufeng Cheng
Summary: Despite advances in research and treatment, lung cancer remains one of the leading causes of cancer-related deaths. The dynamic communication network in the tumor microenvironment, particularly involving cancer-associated fibroblasts (CAFs) and long non-coding RNAs (lncRNAs), plays a significant role in tumor initiation and development. Understanding the molecular mechanisms and biomarkers related to CAFs can greatly contribute to the precise treatment of lung cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Maliheh Entezari, Mehrdokht Sadrkhanloo, Mohsen Rashidi, Sholeh Etehad Asnaf, Afshin Taheriazam, Mehrdad Hashemi, Milad Ashrafizadeh, Ali Zarrabi, Navid Rabiee, Kiavash Hushmandi, Sepideh Mirzaei, Gautam Sethi
Summary: Macrophages in the tumor microenvironment can be influenced by non-coding RNAs, such as miRNAs, lncRNAs, and circRNAs, which in turn affect tumor progression and therapy response. Exosomal ncRNAs derived from tumor cells or macrophages play a role in modulating macrophage polarization and tumor microenvironment remodeling. These ncRNAs, especially exosomal ncRNAs, have the potential to serve as non-invasive biomarkers for tumor diagnosis.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)