Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt, Gregg C. Fonarow, Lee R. Goldberg, Maya Guglin, Richard A. Josephson, Daniel E. Forman, Grace Lin, JoAnn Lindenfeld, Chris O'Connor, Gurusher Panjrath, Ileana L. Pina, Tina Shah, Shashank S. Sinha, Eugene Wolfel
Summary: Cardiac rehabilitation, which includes exercise training, risk factor modification, and outcomes assessment, is safe and beneficial for patients with HF. Despite its effectiveness and cost-efficiency, it is currently underused and should be prioritized as part of standard care for HF patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Elizabeth W. Regan, Reed Handlery, Jill C. Stewart, Joseph L. Pearson, Sara Wilcox, Stacy Fritz
Summary: This study integrated survivors of stroke into a standard exercise-based CR program and evaluated the impact through physical function measures and qualitative assessment. Results showed that exercise-based CR could significantly improve cardiovascular endurance, health status, and quality of life for survivors of stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Oncology
Hartmut Bertz
Summary: Patients undergoing allogeneic haematopoietic stem cell transplantation require intensive physical and psychological rehabilitation, typically involving a specialized multidisciplinary team in collaboration with the primary transplant center.
Review
Cardiac & Cardiovascular Systems
Gerene S. Bauldoff, Brian W. Carlin
Summary: Patients with cardiovascular disease can greatly benefit from participating in cardiac rehabilitation programs. However, many of these patients also have undiagnosed and undertreated pulmonary diseases. This article addresses the methods for evaluating and managing patients with both cardiovascular and pulmonary diseases.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Review
Cardiac & Cardiovascular Systems
Ahmad Sabbahi, Justin M. Canada, Abraham Samuel Babu, Richard Severin, Ross Arena, Cemal Ozemek
Summary: Cardiac rehabilitation programs are standard-of-care in cardiovascular medicine. Aerobic exercise training is crucial for improving cardiorespiratory fitness.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Rehabilitation
Markaela L. Bluhm, Kellie N. Hoehing, Rachael K. Nelson, Micah N. Zuhl
Summary: This study aimed to investigate the effect of cardiac rehabilitation on changes in functional capacity among patients with cardiovascular disease and a comorbidity of type 2 diabetes mellitus. The results of the study showed that patients with cardiovascular disease and type 2 diabetes mellitus experienced less improvement in functional capacity after cardiac rehabilitation compared to patients without type 2 diabetes mellitus.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Cardiac & Cardiovascular Systems
Cindy H. Nguyen, Susan Marzolini, Paul Oh, Scott G. Thomas
Summary: The study demonstrated significant improvements in VO2peak for patients with PAD, CAD, and BOTH following a 6-month CR program. Despite similar prescribed walking distance and duration, improvements in VO2peak were less pronounced in patients with PAD and BOTH compared to those with CAD. Further exploration of alternate exercise strategies for PAD patients is recommended.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Krzysztof Smarz, Tomasz Jaxa-Chamiec, Beata Zaborska, Maciej Tysarowski, Andrzej Budaj
Summary: Cardiac rehabilitation after acute myocardial infarction in patients with preserved left ventricular ejection fraction can improve exercise capacity, particularly through increased heart rate response and improved peripheral oxygen extraction during exercise.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rehabilitation
Matthew R. Ely, Grant D. Schleifer, Tamanna K. Singh, Aaron L. Baggish, J. Andrew Taylor
Summary: This study aimed to investigate the effects of different exercise training modes on cardiac atrophy and loss of function in patients with acute spinal cord injury (SCI). The results showed that neither upper-body exercise alone nor a combination of upper-body exercise with lower-body electrical stimulation had a significant impact on cardiac structure and function. This suggests that current rehabilitative aerobic exercise practices are not effective in preventing cardiac decline in individuals with SCI and further interventions are needed.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Lars Hermann Tang, Patrick Doherty, Soren T. Skou, Alexander Harrison
Summary: The purpose of this study was to explore the characteristics associated with provision and outcomes of a long-term assessment in cardiac rehabilitation (CR). Patients in optimal risk factor stage upon completion of phase II CR had a higher likelihood of being assessed at 12 months and maintaining an optimal stage.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Martin Smith, Jessica Orchard, Andre La Gerche, Robyn Gallagher, Jane Fitzpatrick
Summary: This review synthesizes the evidence on the effectiveness of modern cardiac rehabilitation programs and examines the outcomes for different age, sex, and fitness level groups. The findings suggest that cardiac rehabilitation can improve fitness levels for all groups, with no independent effect of sex or age. A more innovative and personalized approach to cardiac rehabilitation is needed to maximize the benefits.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kyle Gobeil, Kevin White, Anusha Bhat, Heidi Szalai, Tara C. Lagu, Quinn R. Pack
Summary: The study found that utilization of cardiac rehabilitation in Takotsubo cardiomyopathy patients is inconsistent, despite the potential benefits of exercise for improving exercise capacity.
Review
Cardiac & Cardiovascular Systems
Philip A. Ades, Sherrie Khadanga, Patrick D. Savage, Diann E. Gaalema
Summary: Participation in cardiac rehabilitation plays a significant role in reducing morbidity and mortality, and improving quality of life. However, participation rates and adherence with cardiac rehabilitation remain below optimal levels. This paper reviews the current status of participation rates and successful interventions, as well as explores the underrepresented populations who are less likely to engage in cardiac rehabilitation.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Rehabilitation
Yoichiro Aoyagi, Etsuko Mori, Hideki Ishii, Yuji Kono, Ayako Sato, Yuki Okochi, Reisuke Funahashi, Hitoshi Kagaya
Summary: This study compared the effects of cardiac rehabilitation therapies performed in wards and rehabilitation units during the COVID-19 pandemic. The results showed that patients receiving ward-based rehabilitation had lower walking distance and speed at discharge compared to those admitted before the outbreak, and they also had shorter exercise time.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Medicine, General & Internal
Catherine Giuliano, Don Vicendese, Sara Vogrin, Rebecca Lane, Andrea Driscoll, Diem Dinh, Katie Palmer, Itamar Levinger, Christopher Neil
Summary: This study investigated the rate and factors associated with referral to cardiac rehabilitation (CR) among patients hospitalized with heart failure (HF). The results showed a low rate of referral, particularly among females, older patients, and those with chronic obstructive pulmonary disease or anemia. Future studies should focus on improving referral processes and implementing strategies to increase referrals to CR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Salvatore Carbone, Hayley E. Billingsley, Paula Rodriguez-Miguelez, Danielle L. Kirkman, Ryan Garten, R. Lee Franco, Duck-chul Lee, Carl J. Lavie
CURRENT PROBLEMS IN CARDIOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Salvatore Carbone, Danielle L. Kirkman, Ryan S. Garten, Paula Rodriguez-Miguelez, Enrique G. Artero, Duck-chul Lee, Carl J. Lavie
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2020)
Article
Biochemistry & Molecular Biology
Meghan G. Ramick, Danielle L. Kirkman, Joseph M. Stock, Bryce J. Muth, William B. Farquhar, Julio A. Chirinos, Paschalis-Thomas Doulias, Harry Ischiropoulos, David G. Edwards
Summary: The study found that dietary nitrate can acutely improve exercise capacity in CKD patients, increasing total work performed, total exercise time, and oxygen consumption at the ventilatory threshold. Further research is needed to investigate the effects of chronic nitrate supplementation on exercise intolerance in CKD patients.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Danielle L. Kirkman, Natalie Bohmke, Hayley E. Billingsley, Salvatore Carbone
FRONTIERS IN ENDOCRINOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Danielle L. Kirkman, Salvatore Carbone, Justin M. Canada, Cory Trankle, Dinesh Kadariya, Leo Buckley, Hailey Billingsley, Jason M. Kidd, Benjamin W. Van Tassell, Antonio Abbate
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Danielle L. Kirkman, Austin T. Robinson, Matthew J. Rossman, Douglas R. Seals, David G. Edwards
Summary: Cardiovascular disease is a leading cause of death in America, with advancing age being a major risk factor. Vascular dysfunction, characterized by endothelial dysfunction and large elastic artery stiffening, is associated with an increased CVD risk. Mitochondria play a crucial role in maintaining vascular homeostasis, and age- and disease-related impairments in mitochondrial function contribute to vascular dysfunction and increase CVD risk.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Virginia L. Mihalick, Justin M. Canada, Ross Arena, Antonio Abbate, Danielle L. Kirkman
Summary: The outbreak of COVID-19 has led to multi-organ damage and reduced cardiorespiratory fitness, while decreased physical activity exacerbates the risk of cardiopulmonary disease. CP exercise testing is crucial in clinical practice and rehabilitation, but precautions need to be taken due to its aerosol generating nature. Recommendations have been provided to prevent the transmission of SARS-CoV-2 during CPET testing.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Hayley E. Billingsley, Dave L. Dixon, Justin M. Canada, Danielle L. Kirkman, Brando Rotelli, Dinesh Kadariya, Natalie Bohmke, Roshanak Markley, Benjamin W. Van Tassell, Francesco S. Celi, Antonio Abbate, Salvatore Carbone
Summary: The study aimed to investigate the impact of caloric intake before or after the evening meal on cardiorespiratory fitness in patients with HFpEF and obesity. Results showed that caloric intake after the evening meal was associated with higher peak oxygen consumption (VO2), and delaying meal time was correlated with greater peak VO2.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Gastroenterology & Hepatology
Mohammad S. Siddiqui, Samarth Patel, Mikael Forsgren, Anh T. Bui, Steve Shen, Taseen Syed, Sherry Boyett, Shanshan Chen, Arun J. Sanyal, Susan Wolver, Danielle Kirkman, Francesco S. Celi, Chandra S. Bhati
Summary: This study evaluated the metabolic flexibility of patients who underwent liver transplantation for NASH cirrhosis. The findings suggest that reduced metabolic flexibility, characterized by impaired fatty acid utilization, may precede the development of non-alcoholic fatty liver disease after transplantation. The study also found a correlation between body mass index and fasting respiratory quotient in the NASH cohort.
LIVER INTERNATIONAL
(2022)
Review
Cardiac & Cardiovascular Systems
Danielle L. Kirkman, Duck-Chul Lee, Salvatore Carbone
Summary: Lean mass abnormalities are common in cardiac rehabilitation patients. Resistance exercise is recommended in current guidelines, but its effects in cardiovascular disease patients are not well-studied compared to aerobic exercise. This review highlights the prevalence of lean mass abnormalities in cardiovascular disease and discusses the potential benefits of resistance exercise.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Rehabilitation
Danielle L. Kirkman, Meghan G. Ramick, Bryce J. Muth, Joseph M. Stock, Raymond R. Townsend, David G. Edwards
Summary: Aerobic exercise training can improve cardiopulmonary function in patients with chronic kidney disease, but does not have a significant impact on physical function and habitual physical activity levels.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Danielle L. Kirkman, Meghan G. Ramick, Bryce J. Muth, Joseph M. Stock, Raymond R. Townsend, David G. Edwards
Summary: This study revealed potential sex differences in arterial hemodynamics and microvascular dysfunction in patients with CKD, with female patients showing poorer central hemodynamics and reduced microvascular function compared to males. The lower microvascular function observed in females may be contributed to by oxidative stress.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Physiology
Danielle L. Kirkman, Joseph M. Stock, Ninette Shenouda, Natalie J. Bohmke, Youngdeok Kim, Jason Kidd, Raymond R. Townsend, David G. Edwards
Summary: This study demonstrates the potential of a mitochondria-targeted therapy, MitoQ, to improve vascular function in patients with CKD. These findings hold promise for future investigations of mitochondria-targeted therapies in CKD.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Review
Physiology
Danielle L. Kirkman, Natalie Bohmke, Salvatore Carbone, Ryan S. Garten, Paula Rodriguez-Miguelez, Robert L. Franco, Jason M. Kidd, Antonio Abbate
Summary: Exertional fatigue is a common issue in patients with chronic kidney disease and end-stage renal disease, impacting their ability to perform daily activities. This review discusses the potential physiological contributors to exercise intolerance in kidney disease patients, highlighting the negative effects and potential interventions to address this symptom. Current and prospective lifestyle, pharmaceutical, and nutraceutical strategies are explored to improve exertional fatigue and quality of life in CKD and ESRD patients.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)