Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease

A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases

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The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer’s disease

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Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns

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Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology

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Highly Elevated Cerebrospinal Fluid Total Tau Level Reflects Higher Likelihood of Non-Amnestic Subtype of Alzheimer’s Disease

(2019) Jagan A. Pillai et al.   JOURNAL OF ALZHEIMERS DISEASE

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(2019) Per Hammarström   Nature Photonics

The basis of cellular and regional vulnerability in Alzheimer’s disease

(2019) Dunja Mrdjen et al.   ACTA NEUROPATHOLOGICA

Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions

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Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology

(2019) Fares Bassil et al.   NEURON

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

(2019) Marius Kollmer et al.   Nature Communications

Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson’s disease and multiple system atrophy

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Rapidly Progressive Alzheimer’s Disease in Two Distinct Autopsy Cohorts

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Tau-targeting therapies for Alzheimer disease

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Artificial strain of human prions created in vitro

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Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

(2018) Bradley R. Groveman et al.   Acta Neuropathologica Communications

Pre-Progression Rates in Alzheimer's Disease Revisited

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Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

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Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline

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Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease

(2017) Jay Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease

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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

(2017) Sofie Nyström et al.   Jove-Journal of Visualized Experiments

Investigating dye performance and crosstalk in fluorescence enabled bioimaging using a model system

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The amyloid hypothesis of Alzheimer's disease at 25 years

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Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease

(2016) Mark Cohen et al.   Prion

Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue

(2016) Jiliang Liu et al.   Scientific Reports

Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β

(2015) Mark L. Cohen et al.   BRAIN

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure-based drug design identifies polythiophenes as antiprion compounds

(2015) Uli S. Herrmann et al.   Science Translational Medicine

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer’s disease

(2014) Mitsuru Shinohara et al.   BRAIN

Genetic Heterogeneity in Alzheimer Disease and Implications for Treatment Strategies

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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

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Implications of prion adaptation and evolution paradigm for human neurodegenerative diseases

(2014) M Enamul Kabir et al.   Prion

Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands

(2014) Karin Magnusson et al.   Prion

Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits

(2013) Sofie Nyström et al.   ACS Chemical Biology

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

Luminescent Conjugated Oligothiophenes for Sensitive Fluorescent Assignment of Protein Inclusion Bodies

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The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates

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Co-existence of Distinct Prion Types Enables Conformational Evolution of Human PrPScby Competitive Selection

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Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

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The genetics and neuropathology of Alzheimer’s disease

(2012) Gerard D. Schellenberg et al.   ACTA NEUROPATHOLOGICA

Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates

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Alzheimer’s Disease: Genetic Polymorphisms and Rate of Decline

(2012) Christian Schmidt et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

β-Sheet Core of Tau Paired Helical Filaments Revealed by Solid-State NMR

(2012) Venita Daebel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular pathogenesis of sporadic prion diseases in man

(2012) Jiri G. Safar   Prion

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

Small Protease Sensitive Oligomers of PrPSc in Distinct Human Prions Determine Conversion Rate of PrPC

(2012) Chae Kim et al.   PLoS Pathogens

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Rapidly Progressive Alzheimer Disease

(2011) Christian Schmidt   ARCHIVES OF NEUROLOGY

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

(2011) Melissa E Murray et al.   LANCET NEUROLOGY

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates

(2011) Therése Klingstedt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

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(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Protease-Sensitive Conformers in Broad Spectrum of Distinct PrPSc Structures in Sporadic Creutzfeldt-Jakob Disease Are Indicator of Progression Rate

(2011) Chae Kim et al.   PLoS Pathogens

Clinical Features of Rapidly Progressive Alzheimer’s Disease

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Novel Pentameric Thiophene Derivatives forin Vitroandin VivoOptical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

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