Article
Health Care Sciences & Services
Yuta Yamaguchi, Shinichiro Nameki, Yasuhiro Kato, Ryotaro Saita, Tomoharu Sato, Sayaka Nagao, Teruaki Murakami, Yuko Yoshimine, Saori Amiya, Takayoshi Morita, Yasutaka Okita, Takahiro Kawasaki, Jun Fujimoto, Yasutaka Ueda, Yuichi Maeda, Akane Watanabe, Hyota Takamatsu, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Atsushi Kumanogoh
Summary: This study investigated the medium-term effects of immunosuppressants on vaccine efficacy in autoimmune inflammatory rheumatic disease (AIRD) patients. The results showed that AIRD patients had significantly lower antibody levels and seropositivity rates compared to healthy controls at Term 2 and Term 3. Glucocorticoids, tumor necrosis factor-alpha inhibitors (TNFis), and abatacept treatments negatively affected the longevity of humoral responses to SARS-CoV-2, including Omicron.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Review
Immunology
Yasuhiro Kato, Takayoshi Morita, Atsushi Kumanogoh
Summary: Coronavirus disease 2019 (COVID-19), originating from Wuhan, China, has been initially controlled by mRNA vaccines, but new variants of severe acute respiratory syndrome coronavirus 2 have emerged and are spreading rapidly. The involvement of the virus in variant strains and the relationship between vaccine efficacy and immunosuppressive drugs have drawn attention, especially among patients with autoimmune inflammatory rheumatic disease (AIRD) who take immunosuppressive drugs. This review examines the relationship between mRNA vaccines and AIRD, discusses the immune response triggered by mRNA vaccines, and outlines the impact of immunosuppressive agents on the vaccine-induced immune response in AIRD patients and the potential side effects of the vaccine, such as exacerbation of underlying diseases.
INFLAMMATION AND REGENERATION
(2023)
Article
Public, Environmental & Occupational Health
Joseph E. Ebinger, Roy Lan, Nancy Sun, Min Wu, Sandy Joung, Gregory J. Botwin, Patrick Botting, Daniah Al-Amili, Harriet Aronow, James Beekley, Bernice Coleman, Sandra Contreras, Wendy Cozen, Jennifer Davis, Philip Debbas, Jacqueline Diaz, Matthew Driver, Justyna Fert-Bober, Quanquan Gu, Mallory Heath, Ergueen Herrera, Amy Hoang, Shehnaz K. Hussain, Carissa Huynh, Linda Kim, Michelle Kittleson, Yunxian Liu, John Lloyd, Eric Luong, Bhavya Malladi, Akil Merchant, Noah Merin, Angela Mujukian, Nathalie Nguyen, Trevor-Trung Nguyen, Valeriya Pozdnyakova, Mohamad Rashid, Koen Raedschelders, Karen L. Reckamp, Kylie Rhoades, Sarah Sternbach, Rocio Vallejo, Shane White, Rose Tompkins, Melissa Wong, Moshe Arditi, Jane C. Figueiredo, Jennifer E. Van Eyk, Peggy B. Miles, Cynthia Chavira, Rita Shane, Kimia Sobhani, Gil Y. Melmed, Dermot P. B. McGovern, Jonathan G. Braun, Susan Cheng, Margo B. Minissian
Summary: Vaccine-related symptoms are generally mild and last less than 2 days. Female sex, prior COVID-19 infection, younger age, and history of hypertension are associated with more noticeable post-vaccine symptoms. This information can help clinicians advise patients on the expected symptomatology following vaccination.
PREVENTIVE MEDICINE
(2021)
Article
Infectious Diseases
Bryan Oronsky, Harry E. Gruber, Wendy Reiners, Tony R. Reid
Summary: The global pandemic of COVID-19 has accelerated vaccine development. The importance of recruiting cellular T-cell immunity in SARS-CoV-2 vaccine candidates is emphasized, and there is a call for the industry to investigate and publish parameters related to cellular immunity in their research reports.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Yan Xie, Yang Liu, Yi Liu
Summary: Concerns about disease flare among patients with rheumatic diseases after COVID-19 vaccination are not supported by current evidence. Flares triggered by vaccinations are generally mild and do not require additional treatment. Therefore, it is recommended for patients with rheumatic diseases to receive the COVID-19 vaccination when their diseases are stable.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kuo-Ming Lee, Syh-Jae Lin, Chung-Jung Wu, Rei-Lin Kuo
Summary: Since the declaration of the COVID-19 pandemic, vaccines against SARS-CoV-2 have been urgently developed and authorized for emergency use. The administration of COVID-19 mRNA vaccines has successfully reduced hospitalization and mortality caused by the viral infection. The development of mRNA vaccine technology is recognized for its contribution to moderating the harms caused by the COVID-19 pandemic.
BIOMEDICAL JOURNAL
(2023)
Article
Immunology
Sebastian Mondaca, Benjamin Walbaum, Nicole Le Corre, Marcela Ferres, Alejandro Valdes, Constanza Martinez-Valdebenito, Cinthya Ruiz-Tagle, Patricia Macanas-Pirard, Patricio Ross, Betzabe Cisternas, Patricia Perez, Olivia Cabrera, Valentina Cerda, Ivana Ormazabal, Aldo Barrera, Maria E. Prado, Maria I. Venegas, Silvia Palma, Richard Broekhuizen, Alexis M. Kalergis, Susan M. Bueno, Manuel A. Espinoza, M. Elvira Balcells, Bruno Nervi
Summary: Cancer patients receiving chemotherapy treatment have a lower immune response to SARS-CoV-2 vaccines. Our study demonstrated that booster vaccines elicit strong humoral and cellular responses among cancer patients receiving chemotherapy, regardless of the type of vaccine used as a priming dose. The homologous vaccine regimen was associated with higher neutralizing antibody positivity and total antibody levels.
Article
Rheumatology
Joo Guan Yeo, Wan Ni Chia, Kai Liang Teh, Yun Xin Book, Sook Fun Hoh, Xiaocong Gao, Lena Das, Jinyan Zhang, Nursyuhadah Sutamam, Amanda Jin Mei Lim, Su Li Poh, Shi Huan Tay, Katherine Nay Yaung, Xin Mei Ong, Sharifah Nur Hazirah, Camillus Jian Hui Chua, Jing Yao Leong, Lin-Fa Wang, Salvatore Albani, Thaschawee Arkachaisri
Summary: This study evaluated the immunogenicity and safety of SARS-CoV-2 mRNA vaccines in adolescents and young adults with childhood-onset rheumatic diseases. The results showed that the vaccines were efficacious in almost all patients after the two-dose regimen, without serious adverse events. However, some patients experienced disease flares after the second vaccination.
Letter
Medicine, General & Internal
Todd Bradley, Elin Grundberg, Rangaraj Selvarangan, Cas LeMaster, Elizabeth Fraley, Dithi Banerjee, Bradley Belden, Daniel Louiselle, Nick Nolte, Rebecca Biswell, Tomi Pastinen, Angela Myers, Jennifer Schuster
Summary: A small study found that antibody responses significantly increased in healthcare workers after receiving a single dose of the SARS-CoV-2 vaccine, including antibodies to spike protein subunits S1 and S2, as well as the receptor-binding domain.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Bjoern Corleis, Donata Hoffmann, Susanne Rauch, Charlie Fricke, Nicole Roth, Janina Gergen, Kristina Kovacikova, Kore Schlottau, Nico Joel Halwe, Lorenz Ulrich, Jacob Schoen, Kerstin Wernike, Marek Widera, Sandra Ciesek, Stefan O. Mueller, Thomas C. Mettenleiter, Domenico Maione, Benjamin Petsch, Martin Beer, Anca Dorhoi
Summary: The authors demonstrate the effectiveness of a low-dose, unmodified, bivalent mRNA vaccine against SARS-CoV-2 variants in rodent models, showing that it induces broadly neutralizing antibodies and robust T-cell responses. Combining optimized mRNA vaccines encoding Beta and Delta Spike sequences could improve control of the COVID-19 pandemic. The bivalent mRNA vaccine reduces viral replication and protects against lethality in mice challenged with Beta and Delta variants, and also generates neutralizing antibodies against the Omicron BA.1 and BA.5 variants in rats.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Elizabeth Fraley, Cas LeMaster, Eric Geanes, Dithi Banerjee, Santosh Khanal, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley
Summary: This study characterized humoral immune responses during vaccination with the BNT162b2 vaccine in individuals with or without prior history of natural SARS-CoV-2 infection, demonstrating differences in antibody levels and epitope specificity between the two groups. The findings support the consideration of prior infection history as a guide for future vaccination strategies and provide valuable insights for vaccine development.
Article
Medicine, General & Internal
L. J. Abu-Raddad, H. Chemaitelly, H. H. Ayoub, S. AlMukdad, H. M. Yassine, H. A. Al-Khatib, M. K. Smatti, P. Tang, M. R. Hasan, P. Coyle, Z. Al-Kanaani, E. Al-Kuwari, A. Jeremijenko, A. H. Kaleeckal, A. N. Latif, R. M. Shaik, H. F. Abdul-Rahim, G. K. Nasrallah, M. G. Al-Kuwari, A. A. Butt, H. E. Al-Romaihi, M. H. Al-Thani, A. Al-Khal, R. Bertollini
Summary: A study in Qatar showed that booster vaccination significantly reduced the incidence of infection with the omicron variant, providing strong protection against Covid-19-related hospitalization and death. Booster effectiveness was observed for both mRNA vaccines, BNT162b2 and mRNA-1273, with lower infection rates and reduced severity of cases among those who received the booster dose.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Carolina Lucas, Chantal B. F. Vogels, Inci Yildirim, Jessica E. Rothman, Peiwen Lu, Vatter Monteiro, Jeff R. Gehlhausen, Melissa Campbell, Julio Silva, Alexandra Tabachnikova, Mario A. Pena-Hernandez, M. Catherine Muenker, Mallery Breban, Joseph R. Fauver, Subhasis Mohanty, Jiefang Huang, Albert C. Shaw, Albert Ko, Saad B. Omer, Nathan D. Grubaugh, Akiko Iwasaki
Summary: This study found that individuals previously infected with the virus had higher antibody titres post-vaccination compared to those who were uninfected, but both groups reached comparable levels of neutralization responses to the ancestral strain after the second vaccine dose. Comprehensive analysis of 16 locally circulating SARS-CoV-2 variants revealed varying degrees of reduction in neutralization capacity associated with specific mutations in the spike gene, suggesting vaccine boosters as a relevant future strategy to counteract the impact of emerging variants on antibody neutralizing activity.
Review
Endocrinology & Metabolism
Abubakr Mohamed, Ploutarchos Tzoulis, Andrea Lora Kossler, Chrysoula Dosiou
Summary: This study describes two cases of thyroid eye disease (TED) activation following mRNA SARS-CoV-2 vaccination and reviews additional cases reported in the literature. The results show that new-onset TED or deterioration of previously stable TED can occur after SARS-CoV-2 vaccination, with most cases occurring in patients with underlying autoimmune thyroid disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Immunology
Nadine G. Rouphael, Angela R. Branche, David J. Diemert, Ann R. Falsey, Cecilia Losada, Lindsey R. Baden, Sharon E. Frey, Jennifer A. Whitaker, Susan J. Little, Satoshi Kamidani, Emmanuel B. Walter, Richard M. Novak, Richard Rupp, Lisa A. Jackson, Tara M. Babu, Angelica C. Kottkamp, Anne F. Luetkemeyer, Lilly C. Immergluck, Rachel M. Presti, Martin Backer, Patricia L. Winokur, Siham M. Mahgoub, Paul A. Goepfert, Dahlene N. Fusco, Robert L. Atmar, Christine M. Posavad, Antonia Netzl, Derek J. Smith, Kalyani Telu, Jinjian Mu, Lisa J. McQuarrie, Mat Makowski, Mamodikoe K. Makhene, Sonja Crandon, David C. Montefiori, Paul C. Roberts, John H. Beigel, Kuleni Abebe
Summary: A comparison was conducted on the serologic responses in adults between a single dose and a two-dose variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine). The findings indicate that a two-dose boosting regimen with a variant vaccine does not enhance the magnitude or durability of the serological responses compared to a single variant vaccine boost.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Rheumatology
A. Venetsanopoulou, Y. Alamanos, A. Skalkou, P. V. Voulgari, Alexandros A. Drosos
Summary: This study investigated the incidence of rheumatoid arthritis (RA) in a geographically defined area of Greece over a 40-year period. The findings showed a decrease in the incidence of RA over the years, particularly in cases with rheumatoid factor (RF) positivity. Greek patients with RA also tend to have a milder expression of the disease compared to northern European countries.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Nafsika Gerolymatou, Athanasios-Dimitrios Bakasis, Paraskevi V. Voulgari, Panayiotis G. Vlachoyiannopoulos
Summary: This retrospective study analyzed the use of MP and NM/R in SARD patients infected with SARS-CoV-2. The results showed favorable outcomes and acceptable safety profiles of the two oral antiviral therapies in this high-risk population. However, cases of COVID-19 rebound were identified, highlighting the need for continuous surveillance to assess the real-world efficacy and safety in subpopulations of interest.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Dimitrios I. Zaridis, Eugenia Mylona, Nikolaos Tachos, Vasileios C. Pezoulas, Grigorios Grigoriadis, Nikos Tsiknakis, Kostas Marias, Manolis Tsiknakis, Dimitrios I. Fotiadis
Summary: Automatic segmentation of the prostate and prostatic zones on MRI is a critical research area. This study introduces a novel image enhancement method, RACLAHE, which improves the performance of CNN models for prostate segmentation. Comparing with four popular image enhancement methods, RACLAHE shows the most consistent improvement in performance across five CNN models. Additionally, a feature-driven methodology is proposed to explain the predictions after image enhancement.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Vasiliki Koulouri, Athanasios-Dimitrios Bakasis, Nikolaos Marketos, Kyriaki Tavernaraki, Mayra Giannelou, Haralampos M. Moutsopoulos, Clio P. Mavragani
Summary: This study aimed to estimate the prevalence of SSc autoantibodies in seropositive RA and primary SS patients, and found that RA ILD patients had a higher frequency of SSc-specific antibodies compared to RA patients without lung involvement. No differences were detected between primary SS groups. These findings suggest that many RA ILD patients may represent an overlap RA/SSc entity and require tailored diagnostic and therapeutic approaches.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Review
Oncology
Stavros P. Papadakos, Konstantinos Arvanitakis, Ioanna E. Stergiou, Vasileios Lekakis, Spyridon Davakis, Maria-Ioanna Christodoulou, Georgios Germanidis, Stamatios Theocharis
Summary: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and toll-like receptor 4 (TLR4) has been found to play a crucial role in HCC and its potential as an immunotherapy target. TLR4 is involved in both innate and adaptive immunity, and its signaling pathway is associated with various cancer hallmarks and mechanisms. Understanding the multiple aspects of the TLR4 pathway in liver diseases and HCC could lead to the development of targeted immunotherapies for HCC.
Review
Oncology
Alexandros Pergaris, Ioannis Genaris, Ioanna E. Stergiou, Jerzy Klijanienko, Stavros P. Papadakos, Stamatios Theocharis
Summary: DAXX and HJURP are proteins involved in many physiological processes and have been implicated in the development of various tumors. This review summarizes studies investigating the expression of these proteins in different tumor types and highlights their role as potential biomarkers for diagnosis and prognosis in cancer.
Review
Oncology
Stavros P. Papadakos, Ioanna E. Stergiou, Nikolina Gkolemi, Konstantinos Arvanitakis, Stamatios Theocharis
Summary: This narrative literature review focuses on the role of EPH/ephrin signaling in liver cancer and its implications for tumor progression and potential therapeutic strategies. It highlights the upregulation of HIF-1α in HCC cells under low oxygen conditions and explores the significance of the EPH/ephrin axis in regulating the hypoxic tumor microenvironment. The review also emphasizes the potential of targeting the EPH/ephrin signaling pathway in liver cancer treatment.
Review
Oncology
Ioanna E. Stergiou, Stavros P. Papadakos, Anna Karyda, Ourania E. Tsitsilonis, Meletios-Athanasios Dimopoulos, Stamatios Theocharis
Summary: The EPH/ephrin signaling axis plays a crucial role in both embryonic development and adult life, and recent studies have shown its involvement in the pathogenesis of various types of solid tumors. In normal hematopoiesis, different patterns of EPH/ephrin expression are associated with the maintenance, differentiation, and function of hematopoietic stem cells and their mature offspring. Abnormalities in the EPH/ephrin pathway have been found to contribute to the development of hematologic malignancies, with both tumor-promoting and tumor-suppressive effects. Understanding the complexity of this signaling pathway in normal and malignant hematopoiesis is essential for the development of potential therapeutic targets.
Review
Cell Biology
Stavros P. Papadakos, Nikolaos Machairas, Ioanna E. Stergiou, Konstantinos Arvanitakis, Georgios Germanidis, Adam Enver Frampton, Stamatios Theocharis
Summary: This article investigates the importance of macrophage-derived exosomes as both sources and targets in hepatocellular carcinoma (HCC) progression. The research found that exosomes derived from HCC cells and other cell types within the tumor microenvironment (TME) can influence macrophage behavior, polarization, and recruitment. Furthermore, the reciprocal interactions between macrophage-derived exosomes and HCC cells, stromal cells, and other immune cells play a role in tumor growth, angiogenesis, metastasis, and immune evasion. The findings contribute to a better understanding of the role of macrophage-derived exosomes in HCC progression and offer new avenues for targeted interventions and improved patient outcomes.
Article
Rheumatology
K. Bitzogli, E. Jahaj, A. -D. Bakasis, E. K. Kapsogeorgou, A. V. Goules, I. Stergiou, V. Pezoulas, C. Antoniadou, P. Skendros, K. Ritis, D. I. Fotiadis, A. Kotanidou, A. G. Tzioufas, P. G. Vlachoyiannopoulos
Summary: This study assessed the prevalence of autoantibodies (AAbs) in mechanically ventilated COVID-19 patients and investigated whether AAbs influenced the clinical outcome. The results showed that COVID-19 patients in the ICU had a higher prevalence of AAbs compared to age-and sex-matched controls. However, no correlation was found between AAbs and disease outcome.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Athina Zarachi, Aikaterini D. Lianou, Vasileios Pezoulas, Ioannis Komnos, Orestis Milionis, Dimitrios Fotiadis, Haralampos Milionis, Ioannis G. Kastanioudakis, Angelos Liontos
Summary: The present study aimed to evaluate the severity of olfactory and gustatory dysfunction (OGD) in COVID-19-positive patients in Northwestern Greece using the visual analogue scale (VAS), and to investigate its possible association with the patients' self-reported symptoms. The results showed that most patients recovered their sense of smell and taste after COVID-19 infection, and the VAS score was a reliable diagnostic tool for assessing OGD. However, larger-scale trials are needed to confirm these findings.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Dionysios Fanidis, Vasileios C. Pezoulas, Dimitrios Fotiadis, Vassilis Aidinis
Summary: Pulmonary fibrosing diseases have become a focus of biomedical research due to their increasing prevalence and association with SARS-CoV-2 infections. This study used machine learning techniques and Shapley values to explain the decisions made by an ensemble learning model in classifying samples based on gene expression values. The proposed gene lists can serve as new diagnostic markers and targets for future research.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos Arvanitakis, Stavros P. Papadakos, Vasileios Lekakis, Theocharis Koufakis, Ioannis G. Lempesis, Eleni Papantoniou, Georgios Kalopitas, Vasiliki E. Georgakopoulou, Ioanna E. Stergiou, Stamatios Theocharis, Georgios Germanidis
Summary: This article examines the association between obesity and hepatocellular carcinoma (HCC), emphasizing the importance of obesity as a risk factor and proposing comprehensive treatment approaches, including lifestyle interventions and pharmacotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)
