Article
Chemistry, Analytical
Eduardo Zapp, Daniela Brondani, Tania Regina Silva, Edivandro Girotto, Hugo Gallardo, Iolanda Cruz Vieira
Summary: According to the World Health Organization, cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide. Therefore, the development of electrochemical biosensors for detecting CVD markers has become an important diagnostic strategy. In this study, a glassy carbon electrode was modified with liquid crystal and gold nanoparticles to successfully detect cardiac troponin I, showing good diagnostic capacity for point-of-care applications.
Article
Chemistry, Analytical
Koji Toma, Koki Oishi, Kenta Iitani, Takahiro Arakawa, Kohji Mitsubayashi
Summary: A surface plasmon-enhanced fluorescence immunosensor was developed for semi-continuous measurement of cardiac troponin I (cTnI). The sensor showed high selectivity and reproducibility, and has the potential for cTnI monitoring.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Saloni Kakkar, Sakshi Chauhan, Rajni Bala, Bharti, Virendra Kumar, Manojkumar Rohit, Vijayender Bhalla
Summary: This article describes a novel nano-sandwich assay using aptamer and peptide functionalized gold nanoparticles for the detection of the cardiac biomarker troponin I. The assay achieves 100% specificity and 90% sensitivity, with a detection limit as low as 0.084 ng/mL, making it promising for point-of-care detection of TnI.
Article
Engineering, Electrical & Electronic
Rajeev K. Sinha
Summary: A wavelength modulation based surface plasmon resonance sensor setup was developed for the detection of cardiac marker proteins, CTnI and CTnT, with a simple approach used for the fabrication of the CTnI/CTnT antibody sensor chip. The developed setup and sensor chip showed good performance for the detection of CTnI and CTnT in direct assay, with detected concentrations well below the onset concentration of these proteins in blood following AMI, allowing for easy detection during their onset period.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Chemistry, Analytical
Mahnaz D. Gholami, Anthony P. O'Mullane, Prashant Sonar, Godwin A. Ayoko, Emad L. Izake
Summary: A novel electrochemical immunosensor was developed for rapid and selective detection of cTnI in blood plasma, demonstrating potential application in pathological laboratories and point-of-care settings.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Vidya Raj, Saji Alex
Summary: A simple enzyme-free colorimetric sensor based on self-assembled gold nanorods on heparin was developed for the detection of cardiac marker cTnI, showing excellent selectivity and detection sensitivity. The system demonstrated good performance even in the presence of various competing substances. The method is cost-effective, easy to operate, and suitable for use in rural healthcare centers.
Article
Engineering, Electrical & Electronic
Yu Wang, Ragini Singh, Sushank Chaudhary, Bingyuan Zhang, Santosh Kumar
Summary: This study developed an optical fiber biosensor for detecting cardiac troponin I using localized surface plasmon resonance (LSPR) technology. The sensor probe's sensitivity and stability were improved by immobilizing graphene oxide, gold nanoparticles, and molybdenum disulfide nanoparticles to the etched fiber surface. The sensing surface was functionalized with an enzyme to enhance selectivity performance.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Nanoscience & Nanotechnology
Carlo Bravin, Vincenzo Amendola
Summary: The study found that the performance of Au NPs-based optical sensors is strongly related to the size, spacing, number, and aggregation state of the particles. By using the CRP/anti-CRP couple, the results provided insights into evaluating the extent of antigen-induced particle aggregation and pointed towards identifying a useful figure of merit for developing particle aggregates with optimal structures for desirable nanosensor response.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Physical
William Morton, Caoimhe Joyce, Jonny Taylor, Mary Ryan, Stefano Angioletti-Uberti, Fang Xie
Summary: The research findings suggest that the geometric properties of gold nanostars can be referenced, similar to the way a nanosphere can be described by its radius, instead of solely relying on the local surface plasmon resonance (LSPR) of the structure. The suggested average tip approximation simplifies the complex nature of nanostars in simulations. By comparing the characteristics of modeled nanostars to synthesized nanostars, the volume, surface area, and number of tips can be approximated without the need for extensive characterization. Understanding the nanoparticle geometry can have implications for drug delivery capacity, identification of hot spots for electron microscopy imaging, and the interaction of particles with cells.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Medical Laboratory Technology
Rasmus Bo Hasselbalch, Jonas Henrik Kristensen, Nicoline Jorgensen, Nina Strandkjaer, Bashir Alaour, Shoaib Afzal, Michael Marber, Henning Bundgaard, Kasper Karmark Iversen
Summary: The hs-cTnI assay showed comparable diagnostic accuracy to the cTnI-U assay for diagnosing myocardial infarction, but measured higher concentrations. This resulted in a higher frequency of acute myocardial injury. A subset of patients had significantly elevated hs-cTnI concentrations without any evidence of heterophilic antibodies.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Geriatrics & Gerontology
Olive Tang, Kunihiro Matsushita, Josef Coresh, Ron C. Hoogeveen, B. Gwen Windham, Christie M. Ballantyne, Elizabeth Selvin
Summary: In older adults, high-sensitivity cardiac troponin I (hs-cTnI) is more predictive of mortality and cardiovascular risk compared to traditional risk factors, and provides better discrimination abilities. Its elevation without clinical cardiovascular disease identifies a high-risk group with comparable mortality risks to those with a history of CVD.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Medical Laboratory Technology
Dorien M. Kimenai, Anoop S. Shah, David A. McAllister, Kuan Ken Lee, Athanasios Tsanas, Steven J. R. Meex, David J. Porteous, Caroline Hayward, Archie Campbell, Naveed Sattar, Nicholas L. Mills, Paul Welsh
Summary: Cardiac troponin concentrations differ in women and men, with women having stronger predictive ability for cardiovascular events. Sex-specific approaches are needed to provide equivalent risk prediction.
CLINICAL CHEMISTRY
(2021)
Article
Medical Laboratory Technology
Peter A. Kavsak, Tara Edge, Chantele Roy, Paul Malinowski, Karen Bamford, Lorna Clark, Shana Lamers, Stephen Hill, Andrew Worster
Summary: The study evaluated the Ortho Clinical Diagnostics VITROS high-sensitivity cardiac troponin I (hs-cTnI) assay in specific matrices and compared it to other hs-cTn assays. The VITROS hs-cTnI assay yielded lower concentrations compared to other assays, with important differences between plasma and serum, but showed excellent clinical performance comparable to other hs-cTn assays.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Remya Radha, Syeda Kiran Shahzadi, Mohammad Hussein Al-Sayah
Summary: Cardiovascular diseases are a major cause of global human death, with myocardial infarction (MI) having the highest morbidity and mortality rates. Cardiac troponin is considered the gold standard as a specific biomarker for cardiac injury, with fluorescence-based immunoassays being the fastest, most accurate, and most sensitive method for detecting cardiac troponins post-MI.
Article
Biochemical Research Methods
Yu Wang, Ragini Singh, Muyang Li, Rui Min, Qiang Wu, Brajesh Kumar Kaushik, Rajan Jha, Bingyuan Zhang, Santosh Kumar
Summary: The article presents the development of a hetro-core optical fiber sensor using localized surface plasmon resonance (LSPR) to detect cardiac troponin I (cTnI) solution. The sensor structure consists of a single-mode fiber - multimode fiber - single-mode fiber (SMS) structure, immobilized with gold and cerium oxide nanoparticles. The sensor has a linear range of 0-1000 ng/mL cTnI, a sensitivity of 3 pm/(ng/mL), and a detection limit of 108.15 ng/mL. It will be used in real-time to detect acute myocardial infarction (AMI).
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Saji Alex, Ashutosh Tiwari
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2015)
Article
Materials Science, Biomaterials
Kun Tian, Saji Alex, Gene Siegel, Ashutosh Tiwari
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2015)
Article
Crystallography
Saji Alex, Kun Tian, Shiang Teng, Gene Siegel, Ashutosh Tiwari
JOURNAL OF CRYSTAL GROWTH
(2014)
Article
Materials Science, Multidisciplinary
A. R. Athira, V. M. Vimuna, Merin Tomy, K. V. Dinesh Babu, Saji Alex, T. S. Xavier
Summary: Surfactant intercalated polypyrrole-exfoliated graphene oxide hybrid thin films were electrodeposited as binder-free electrodes for supercapacitors. The electrochemical performance was significantly improved by tuning the morphology of the composite films through the concentration of the anionic surfactant sodium lauryl sulfate (SLS).
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
V. M. Vimuna, U. M. Karthika, Saji Alex, T. S. Xavier
Summary: Microsphere MnO2/rGO composites were synthesized and characterized for supercapacitor electrodes. The RX-GMN@80 composite exhibited a high surface area and abundant porosity, which facilitated ion diffusion. Electrochemical analyses demonstrated that the RX-GMN@80 composite had excellent specific capacitance and energy density, as well as long cycle life and high efficiency.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Vidya Raj, Saji Alex
Summary: A simple enzyme-free colorimetric sensor based on self-assembled gold nanorods on heparin was developed for the detection of cardiac marker cTnI, showing excellent selectivity and detection sensitivity. The system demonstrated good performance even in the presence of various competing substances. The method is cost-effective, easy to operate, and suitable for use in rural healthcare centers.
