Article
Biophysics
Jing Yang Quek, Richard Bright, P. R. L. Dabare, Krasimir Vasilev
Summary: This study developed a ROS-responsive micellar system for carrying NSAIDs, which showed greater anti-inflammatory potency compared to the free form of the drug. The findings highlight the potential of this system for the treatment of relevant inflammatory conditions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
JunJie Tang, Xiaoge Zhang, Lili Cheng, Yadong Liu, You Chen, Zhaozhong Jiang, Jie Liu
Summary: This study presents a novel oxygen-independent, ROS-amplifying chemo-sonodynamic antitumor therapy using pH/GSH/ROS triple-responsive PEG-PPMDT nanoparticles. The therapy effectively releases drugs and amplifies ROS levels in tumor cells, leading to significant tumor growth inhibition. The therapy also demonstrates minimal toxicity to main organs and can be guided by Fe(3)O(4) encapsulated in the nanoparticles.
BIOACTIVE MATERIALS
(2022)
Article
Polymer Science
Hyun-Chul Kim, Eunjoo Kim, Se Guen Lee, Sung Jun Lee, Sang Won Jeong, Young Jae Lee, Mi Kyung Kwon, Seong-Kyoon Choi, Jun Seong Hwang, Eunsook Choi
Summary: ROS-responsive nanocarriers have been synthesized for controlled release of anticancer drugs. The DTTP micelles are highly sensitive to ROS, releasing drugs in tumor cells with strong antitumor activity.
Article
Biophysics
Xiang Wang, Kang Song, Yan Fan, Jun Du, Jinliang Liu, Jiayu Xu, Lulu Zheng, Ruizhuo Ouyang, Yuhao Li, Yuqing Miao, Dawei Zhang
Summary: The study constructed an ultrasound-triggered ROS damage nanoamplifier using a synergistic strategy of ROS damage and decreased tumor self-protection capability, enhancing the treatment efficacy for mutant p53 tumors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Meiyao Wang, Huazhen Xu, Tongfei Li, Ke Li, Quan Zhang, Siyi Chen, Li Zhao, Jincao Chen, Xiao Chen
Summary: Sonodynamic therapy (SDT) is a promising treatment for glioblastoma (GBM) that relies on the selective accumulation of a sonosensitizer in the tumor and ultrasound irradiation to generate cytotoxic actions. To overcome the barriers in GBM, a delivery strategy using platelets with ultrasound-triggered release property was proposed. The loaded platelets released the sonosensitizer upon ultrasound activation, resulting in ROS generation and cell death in GBM cells.
Article
Chemistry, Multidisciplinary
Baojie Wen, Danqing Huang, Chuanhui Song, Jingyang Shan, Yuanjin Zhao
Summary: This study presents a novel ultrasound responsive natural pollen delivery system for synergistic treatment of triple negative breast cancer (TNBC) using simultaneous loading of chemotherapeutics and gaseous drugs. The hollow structure of pollen grains carries oxygen-enriched perfluorocarbon (PFC), and the porous spinous process structure adsorbs the chemotherapeutic drug doxorubicin (DOX) (PO/D-PGs). Ultrasound triggers oxygen release from PFC and excites DOX to realize chemo-sonodynamic therapy. The PO/D-PGs are demonstrated to effectively enhance oxygen concentration and increase the production of reactive oxygen species in the presence of low-intensity ultrasound, synergistically enhancing tumor killing ability. Based on ultrasound-facilitated PO/D-PGs, this synergistic therapy significantly enhances the antitumor effect in a mouse TNBC model, suggesting its potential as an effective strategy to enhance chemo-sonodynamic therapy for TNBC.
Review
Pharmacology & Pharmacy
Tao Sun, Chen Jiang
Summary: Drug delivery systems (DDS) triggered by local microenvironment represent the state-of-art of nanomedicine design, aiming to precisely recognize diseased sites, reduce side effects, and expand the therapeutic window. However, the design of DDS functioning at microcosmic levels is still challenging and underexploited.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Pu Yao, Xiaowen Wang, Qianmei Wang, Qing Dai, Yu Peng, Qian Yuan, Nan Mou, Shan Lv, Bangbi Weng, Yu Wang, Fengjun Sun
Summary: This study presents a pH/ROS-responsive nanoplatform for drug delivery in the treatment of breast cancer, which can actively target cancer cells and selectively release drugs for improved therapeutic efficacy.
Article
Engineering, Biomedical
Jianming Zhao, Jirong Shi, Xiangdan Meng, Chenchen Gong, Peng Wu, Zhou Yang, Haifeng Dong
Summary: Stimuli-responsive nanoplatforms have great potential for delivering drugs to kill cancer cells with high accuracy and minimal invasiveness. In this study, ROS-responsive nanoscale coordination polymers were designed, and the release of drugs was enhanced under ultrasound stimulation. The nanoplatform achieved the synergistic effect of sonodynamic therapy and chemotherapy, and showed good targeting ability to cancer cells.
ACTA BIOMATERIALIA
(2022)
Review
Chemistry, Multidisciplinary
Zeyu Jiang, Wenjing Xiao, Qinrui Fu
Summary: Sonodynamic therapy (SDT) has significant potential in the treatment of deep tumors and multidrug-resistant bacterial infections, but traditional sonosensitizers have limitations. Stimuli-responsive nano-sonosensitizers that utilize the local microenvironment and ultrasound stimulation offer a promising alternative for efficient and safe treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Fan Zhuang, Qiong Ma, Caihong Dong, Huijing Xiang, Yujia Shen, Pei Sun, Cuixian Li, Yixin Chen, Beilei Lu, Yu Chen, Beijian Huang
Summary: The study developed a sequential ultrasound/hypoxia-sensitive sonochemotherapeutic nanoprodrug that combines hypoxic condition with sonodynamic therapy to enhance the treatment outcome of tumors.
Article
Chemistry, Multidisciplinary
Shikai Liu, Wenting Li, He Ding, Boshi Tian, Linyang Fang, Xudong Zhao, Ruoxi Zhao, Baichao An, Lianfei Ding, Lei Zhong, Piaoping Yang
Summary: This study designs chlorin e6 (Ce6) and bovine serum albumin-ruthenium dioxide nanozyme (BCNR) for ultrasound-triggered peroxynitrite-mediated ferroptosis. The Ce6 and RuO2 generate highly efficient singlet oxygen (O-1(2)) upon ultrasound stimulation. BCNR releases nitric oxide (NO) on-demand, which reacts with O-1(2) forming highly cytotoxic peroxynitrite (ONOO-). BCNR nanozyme consumes glutathione (GSH) and downregulates glutathione reductase, ensuring complete depletion of GSH within the tumor and enhancing ferroptosis sensitization of cancer cells.
Article
Nanoscience & Nanotechnology
Thuy Giang Nguyen Cao, Ji Hee Kang, Jae Young You, Han Chang Kang, Won Jong Rhee, Young Tag Ko, Min Suk Shim
Summary: Utilizing exosomes as nanocarriers, this study effectively delivered the sonosensitizer ICG to tumor tissues, with surface modification using the cancer-targeting ligand FA to enhance ROS production in breast cancer cells and inhibit tumor growth. The active cancer-targeted FA-ExoICG showed superior tumor accumulation, pharmacokinetic properties, and sonotoxicity against cancer cells compared to ExoICG and free ICG, demonstrating its potential as an effective nanosonosensitizer for safe and targeted cancer treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Chong Shen, Ming Gao, Haimin Chen, Yanting Zhan, Qiumei Lan, Zhimin Li, Wei Xiong, Zainen Qin, Li Zheng, Jinmin Zhao
Summary: This study developed a smart nanoscale probe targeting cartilage, able to activate in response to excessive ROS and deactivate in normal conditions, effectively reducing cartilage damage in patients with osteoarthritis.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Chufen Yang, Delin Wang, Wenyao Liu, Zexiong Yang, Teng He, Fang Chen, Wenjing Lin
Summary: In this study, folate (FA) modified dual pH/reduction-responsive mixed polymeric micelles were successfully assembled for high loading, controlled release, and active targeted delivery. The micelles showed excellent drug loading capacity and encapsulation efficiency, and demonstrated well-controlled release performance in neutral and acidic environments. Cytotoxicity assays further revealed the superior inhibitory effect of FA-modified micelles on cancer cells. These findings suggest that the developed micelles have great potential for anticancer drug delivery.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
