Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription

HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

(2021) Alicia Tapias et al.   eLife

Histone sumoylation and chromatin dynamics

(2021) Hong-Yeoul Ryu et al.   NUCLEIC ACIDS RESEARCH

Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism

(2021) Deepti Abbey et al.   CTS-Clinical and Translational Science

In vivo analysis of the evolutionary conserved BTD-box domain of Sp1 and Btd during Drosophila development

(2020) David Blom-Dahl et al.   DEVELOPMENTAL BIOLOGY

The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole

(2020) Jelly H.M. Soffers et al.   GENES & DEVELOPMENT

Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouse

(2020) Li Niu et al.   Cell and Bioscience

Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability

(2019) Benjamin Cogné et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Tracing the origin and evolution of pseudokinases across the tree of life

(2019) Annie Kwon et al.   Science Signaling

Depletion of TRRAP induces p53‐independent senescence in liver cancer by downregulating mitotic genes

(2019) Suet‐Yan Kwan et al.   HEPATOLOGY

New insights into the evolutionary conservation of the sole PIKK pseudokinase Tra1/TRRAP

(2019) Alberto Elías-Villalobos et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations

(2019) Cedric Magaway et al.   Cells

TRRAP is a central regulator of human multiciliated cell formation

(2018) Zhao Wang et al.   JOURNAL OF CELL BIOLOGY

Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression

(2018) Sofia Nasif et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

De novo variant of TRRAP in a patient with very early onset psychosis in the context of non-verbal learning disability and obsessive-compulsive disorder: a case report

(2018) Chrystal F. Mavros et al.   BMC Medical Genetics

Elevated histone H3 acetylation and loss of the Sp1–HDAC1 complex de-repress the GM2-synthase gene in renal cell carcinoma

(2018) Avisek Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter

(2017) Deepa Rajagopalan et al.   PLoS Pathogens

Maximal Expression of the Evolutionarily Conserved Slit2 Gene Promoter Requires Sp1

(2015) Jacquelyn Saunders et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Sp1 and the ‘hallmarks of cancer’

(2015) Kate Beishline et al.   FEBS Journal

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response

(2015) Andrew E.H. Elia et al.   MOLECULAR CELL

Trrap-Dependent Histone Acetylation Specifically Regulates Cell-Cycle Gene Transcription to Control Neural Progenitor Fate Decisions

(2014) Alicia Tapias et al.   Cell Stem Cell

Histone Acetyltransferase Cofactor Trrap Maintains Self-Renewal and Restricts Differentiation of Embryonic Stem Cells

(2013) Carla Sawan et al.   STEM CELLS

The Specificity Protein Factor Sp1 Mediates Transcriptional Regulation of P2X7 Receptors in the Nervous System

(2012) Paula García-Huerta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex

(2011) Dominique Helmlinger et al.   EMBO JOURNAL

Interplay of Posttranslational Modifications in Sp1 Mediates Sp1 Stability during Cell Cycle Progression

(2011) Yi-Ting Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of Sp1 and Sp3 in normal and cancer cell biology

(2010) Lin Li et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation

(2010) Mary L. Spengler et al.   CELL CYCLE

Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells

(2009) Wen-Chun Hung et al.   CANCER LETTERS

Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin

(2009) Catherine Creppe et al.   CELL

Emerging common themes in regulation of PIKKs and PI3Ks

(2009) Harri Lempiäinen et al.   EMBO JOURNAL

Histone Acetyltransferase Cofactor Trrap Is Essential for Maintaining the Hematopoietic Stem/Progenitor Cell Pool

(2009) J. I. Loizou et al.   JOURNAL OF IMMUNOLOGY

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

(2009) R. L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sp1: Emerging roles—Beyond constitutive activation of TATA-less housekeeping genes

(2008) Inken Wierstra   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcription factor Sp1 dysregulation in Alzheimer's disease

(2008) Bruce A. Citron et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2α

(2007) Yan Zhang et al.   PEPTIDES