期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/ijms222312992
关键词
thyroid cancer; sex bias; estrogens; reactive oxygen species (ROS); oncogenes
资金
- French National Network for Rare Endocrine Diseases FIRENDO
Differentiated thyroid cancers are more common in women, possibly due to differences in patient behavior and thyroid investigations, as well as the potential impact of sex hormones. The reasons behind the poorer prognosis of thyroid cancer in male patients remain poorly explained.
Differentiated thyroid cancers are more frequent in women than in men. These different frequencies may depend on differences in patient's behavior and in thyroid investigations. However, an impact on sexual hormones is likely, although this has been insufficiently elucidated. Estrogens may increase the production of mutagenic molecules in the thyroid cell and favor the proliferation and invasion of tumoral cells by regulating both the thyrocyte enzymatic machinery and the inflammatory process associated with tumor growth. On the other hand, the worse prognosis of thyroid cancer associated with the male gender is poorly explained.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据