Discovery and Validation of Lmj_04_BRCT Domain, a Novel Therapeutic Target: Identification of Candidate Drugs for Leishmaniasis
出版年份 2021 全文链接
标题
Discovery and Validation of Lmj_04_BRCT Domain, a Novel Therapeutic Target: Identification of Candidate Drugs for Leishmaniasis
作者
关键词
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出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 19, Pages 10493
出版商
MDPI AG
发表日期
2021-09-29
DOI
10.3390/ijms221910493
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone
- (2020) Fernanda A. H. Batista et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- In Vitro and In Vivo Characterization of Potent Antileishmanial Methionine Aminopeptidase 1 Inhibitors
- (2020) Felipe Rodriguez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A chemical inhibitor of heat shock protein 78 (HSP78) from Leishmania donovani represents a potential anti-leishmanial drug candidate
- (2020) Sonali Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Safety, tolerability, and pharmacokinetics of a novel oral amphotericin B formulation (iCo-019) following single-dose administration to healthy human subjects: An alternative approach to parenteral amphotericin B administration
- (2020) Peter Hnik et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Design, synthesis, and in vitro biological evaluation of novel thiazolopyrimidine derivatives as antileishmanial compounds
- (2020) Huseyin Istanbullu et al. ARCHIV DER PHARMAZIE
- Molecular modeling and simulation study of homoserine kinase as an effective leishmanial drug target
- (2020) Rohan J. Meshram et al. JOURNAL OF MOLECULAR MODELING
- Modeling and simulation study to identify threonine synthase as possible drug target in Leishmania major
- (2020) Rohan J. Meshram et al. MOLECULAR DIVERSITY
- An overview of biochemically characterized drug targets in metabolic pathways of Leishmania parasite
- (2020) Shweta Raj et al. PARASITOLOGY RESEARCH
- Rationale for Use of Amiodarone and Its Derivatives for Treatment of Chagas’ Disease and Leishmaniasis
- (2020) Gustavo Benaim et al. CURRENT PHARMACEUTICAL DESIGN
- Drug-induced reactive oxygen species–mediated inhibitory effect on growth of Trypanosoma evansi in axenic culture system
- (2020) Rajender Kumar et al. PARASITOLOGY RESEARCH
- Berberine-Loaded Liposomes for the Treatment of Leishmania infantum-Infected BALB/c Mice
- (2020) Alba Calvo et al. Pharmaceutics
- LmjF.22.0810 from Leishmania major Modulates the Th2-Type Immune Response and Is Involved in Leishmaniasis Outcome
- (2020) Andrés Vacas et al. Biomedicines
- UniProt: the universal protein knowledgebase in 2021
- (2020) et al. NUCLEIC ACIDS RESEARCH
- Synthesis, In Silico, and In Vitro Evaluation of Anti-Leishmanial Activity of Oxadiazoles and Indolizine Containing Compounds Flagged against Anti-Targets
- (2019) Strahinja Stevanovic et al. MOLECULES
- The EMBL-EBI search and sequence analysis tools APIs in 2019
- (2019) Fábio Madeira et al. NUCLEIC ACIDS RESEARCH
- Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate
- (2019) Luz H. Patino et al. Parasites & Vectors
- CDD/SPARCLE: the conserved domain database in 2020
- (2019) Shennan Lu et al. NUCLEIC ACIDS RESEARCH
- Designing Ligands for Leishmania, Plasmodium, and Aspergillus N-Myristoyl Transferase with Specificity and Anti-Target-Safe Virtual Libraries
- (2018) Alfonso T. Garcia-Sosa Current Computer-Aided Drug Design
- SWISS-MODEL: homology modelling of protein structures and complexes
- (2018) Andrew Waterhouse et al. NUCLEIC ACIDS RESEARCH
- Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis
- (2018) Laura M. Alcântara et al. International Journal for Parasitology-Drugs and Drug Resistance
- LEISHMANICIDAL ACTIVITY OF ISOSELENOCYANATE DERIVATIVES.
- (2018) Celia Fernández-Rubio et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx
- (2017) Nagakumar Bharatham et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Structural Insight into BLM Recognition by TopBP1
- (2017) Luxin Sun et al. STRUCTURE
- Drug resistance and treatment failure in leishmaniasis: A 21st century challenge
- (2017) Alicia Ponte-Sucre et al. PLoS Neglected Tropical Diseases
- SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
- (2017) Antoine Daina et al. Scientific Reports
- Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors
- (2016) Birgit Viira et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Repurposing strategies for tropical disease drug discovery
- (2016) Dana M. Klug et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets
- (2016) Sanja Glisic et al. MOLECULES
- The SWISS-MODEL Repository—new features and functionality
- (2016) Stefan Bienert et al. NUCLEIC ACIDS RESEARCH
- Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain
- (2015) E. Railey White et al. ACS Chemical Biology
- A Small-Molecule Protein-Protein Interaction Inhibitor of PARP1 That Targets Its BRCT Domain
- (2015) Zhenkun Na et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Leishmanicidal Activities of Novel Methylseleno-Imidocarbamates
- (2015) Celia Fernández-Rubio et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The I-TASSER Suite: protein structure and function prediction
- (2015) Jianyi Yang et al. NATURE METHODS
- I-TASSER server: new development for protein structure and function predictions
- (2015) Jianyi Yang et al. NUCLEIC ACIDS RESEARCH
- Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1
- (2013) Xuying Liu et al. BIOCHEMISTRY
- Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
- (2013) G. Madhavi Sastry et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- High-Resolution Comparative Modeling with RosettaCM
- (2013) Yifan Song et al. STRUCTURE
- Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction
- (2012) Jian Ye et al. BMC BIOINFORMATICS
- Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option
- (2012) Ziyan Yuan Pessetto et al. BREAST CANCER RESEARCH AND TREATMENT
- Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking
- (2012) Michael M. Mysinger et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mechanistic Insights into Phosphopeptide–BRCT Domain Association: Preorganization, Flexibility, and Phosphate Recognition
- (2012) Yu-ming M. Huang et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Functional Evolution of BRCT Domains from Binding DNA to Protein
- (2011) Zi-Zhang Sheng et al. Evolutionary Bioinformatics
- Structure–Activity Relationship Studies To Probe the Phosphoprotein Binding Site on the Carboxy Terminal Domains of the Breast Cancer Susceptibility Gene 1
- (2011) Ziyan Yuan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective
- (2010) Nicolas Guex et al. ELECTROPHORESIS
- The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts
- (2010) R. Craig MacLean et al. NATURE REVIEWS GENETICS
- Rational Approaches for Drug Designing Against Leishmaniasis
- (2009) Anil Kumar Shukla et al. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
- Miltefosine Promotes IFN- -Dominated Anti-Leishmanial Immune Response
- (2009) P. Wadhone et al. JOURNAL OF IMMUNOLOGY
- GPCR 3D homology models for ligand screening: Lessons learned from blind predictions of adenosine A2a receptor complex
- (2009) Vsevolod Katritch et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Structure prediction for CASP8 with all-atom refinement using Rosetta
- (2009) Srivatsan Raman et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Docking and Virtual Screening Using Distributed Grid Technology
- (2009) Alfonso T. García-Sosa et al. Quantitative structure-activity relationships & combinatorial science
- Meglumine antimonate directly increases phagocytosis, superoxide anion and TNF-α production, but only via TNF-α it indirectly increases nitric oxide production by phagocytes of healthy individuals, in vitro
- (2008) Maria Imaculada Muniz-Junqueira et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Discovery of Novel Chemotypes to a G-Protein-Coupled Receptor through Ligand-Steered Homology Modeling and Structure-Based Virtual Screening
- (2008) Claudio N. Cavasotto et al. JOURNAL OF MEDICINAL CHEMISTRY
- MODBASE, a database of annotated comparative protein structure models and associated resources
- (2008) U. Pieper et al. NUCLEIC ACIDS RESEARCH
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