Stem Cell Transplantation and Cell-Free Treatment for Periodontal Regeneration

Increasing attention has been paid to cell-based medicines. Many in vivo and in vitro studies have demonstrated the efficacy of stem cell transplantation for the regeneration of periodontal tissues over the past 20 years. Although positive evidence has accumulated regarding periodontal regeneration using stem cells, the exact mechanism of tissue regeneration is still largely unknown. This review outlines the practicality and emerging problems of stem cell transplantation therapy for periodontal regeneration. In addition, possible solutions to these problems and cell-free treatment are discussed.

Automated summary

This article discusses the progress in cell-based medicine for periodontal regeneration, highlighting the lack of understanding regarding the exact mechanism of tissue regeneration despite positive evidence. The article also explores practical issues and possible solutions in stem cell transplantation therapy, as well as the potential of cell-free treatment.