Emerging View on the Molecular Functions of Sec62 and Sec63 in Protein Translocation

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

(2021) Samuel Itskanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SEC62 and SEC63 Expression in Hepatocellular Carcinoma and Tumor-Surrounding Liver Tissue

(2021) Markus Casper et al.   Visceral Medicine

Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex

(2021) Mark Sicking et al.   Cells

Cotranslational Targeting and Posttranslational Translocation can Cooperate in Spc3 Topogenesis

(2021) Sung-jun Jung et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of signal peptide features for substrate specificity in human Sec62/Sec63‐dependent ER protein import

(2020) Stefan Schorr et al.   FEBS Journal

Architecture of the active post‐translational Sec translocon

(2020) Tsai‐Hsuan Weng et al.   EMBO JOURNAL

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

(2019) Anke Ziska et al.   Biology Open

Membrane Protein Integration and Topogenesis at the ER

(2019) Martin Spiess et al.   PROTEIN JOURNAL

Identification of 3q oncogene SEC62 as a marker for distant metastasis and poor clinical outcome in invasive ductal breast cancer

(2019) Ferenc Zoltan Takacs et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Proper insertion and topogenesis of membrane proteins in the ER depend on Sec63

(2019) Sung-jun Jung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

(2018) Sarah Haßdenteufel et al.   Cell Reports

Profiling of signal sequence characteristics and requirement of different translocation components

(2018) Chewon Yim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure of the post-translational protein translocation machinery of the ER membrane

(2018) Xudong Wu et al.   NATURE

Structure of the posttranslational Sec protein-translocation channel complex from yeast

(2018) Samuel Itskanov et al.   SCIENCE

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins

(2017) Arati Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erratum: Corrigendum: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2017) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases

(2017) Sven Lang et al.   Frontiers in Physiology

Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions

(2016) Maximilian Linxweiler et al.   BMC CANCER

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

Crystal structure of a substrate-engaged SecY protein-translocation channel

(2016) Long Li et al.   NATURE

Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma

(2016) SILKE WEMMERT et al.   Oncology Letters

Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events

(2015) Brian J. Conti et al.   MOLECULAR CELL

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

(2015) Bhalchandra Jadhav et al.   Nature Communications

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins

(2014) S.-j. Jung et al.   JOURNAL OF CELL SCIENCE

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

(2014) Andrew L MacKinnon et al.   eLife

The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis

(2013) Felix Willmund et al.   CELL

Sec62 Protein Mediates Membrane Insertion and Orientation of Moderately Hydrophobic Signal Anchor Proteins in the Endoplasmic Reticulum (ER)

(2013) Johannes H. Reithinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages

(2013) Nicholas Johnson et al.   PLoS One

BiP-mediated closing of the Sec61 channel limits Ca2+leakage from the ER

(2012) Nico Schäuble et al.   EMBO JOURNAL

Different effects of Sec61 , Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

(2012) S. Lang et al.   JOURNAL OF CELL SCIENCE

Orientation of Internal Signal-Anchor Sequences at the Sec61 Translocon

(2012) Lucyna Kocik et al.   JOURNAL OF MOLECULAR BIOLOGY

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

(2012) Asvin K. K. Lakkaraju et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of Heterozygosity Is Present in SEC63 Germline Carriers with Polycystic Liver Disease

(2012) Manoe J. Janssen et al.   PLoS One

Sec62 Bridges the Gap from 3q Amplification to Molecular Cell Biology in Non–Small Cell Lung Cancer

(2011) Maximilian Linxweiler et al.   AMERICAN JOURNAL OF PATHOLOGY

Sec61 complexes form ubiquitous ER Ca2+leak channels

(2011) Sven Lang et al.   Channels

An interaction between human Sec63 and nucleoredoxin may provide the missing link between theSEC63gene and polycystic liver disease

(2011) Linda Müller et al.   FEBS LETTERS

Sec62 protein level is crucial for the ER stress tolerance of prostate cancer

(2011) Markus Greiner et al.   PROSTATE

Interaction of calmodulin with Sec61α limits Ca2+leakage from the endoplasmic reticulum

(2010) Frank Erdmann et al.   EMBO JOURNAL

Structural Studies and the Assembly of the Heptameric Post-translational Translocon Complex

(2010) Yoichiro Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary Gain of Function for the ER Membrane Protein Sec62 from Yeast to Humans

(2010) Linda Müller et al.   MOLECULAR BIOLOGY OF THE CELL

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

(2010) P. F. Egea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a complex of the ATPase SecA and the protein-translocation channel

(2008) Jochen Zimmer et al.   NATURE