Article
Multidisciplinary Sciences
Nicola Veronese, Ligia J. Dominguez, Saverio Ragusa, Luisa Solimando, Lee Smith, Francesco Bolzetta, Stefania Maggi, Mario Barbagallo
Summary: The study examined the relationship between dietary acrylamide intake and physical performance tests, revealing that higher intake was associated with poorer physical performance, suggesting a potential role for this food contaminant as a risk factor for sarcopenia.
Review
Pharmacology & Pharmacy
Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale
Summary: Impairment in mitochondrial homeostasis plays a crucial role in sarcopenia, leading to loss of muscle mass and strength. Targeting mitochondrial defects and developing drug delivery systems show promising potential for prevention and treatment, but require further clinical studies for promotion.
Article
Cardiac & Cardiovascular Systems
Walter Sepulveda-Loyola, Larissa Araujo de Castro, Andressa Keiko Matsumoto, Carlos Augusto Camillo, Decio Sabbatini Barbosa, Carrie Chueiri Ramos Galvan, Vanessa Suziane Probst
Summary: The study found that oxidative stress in patients with COPD is associated with sarcopenia, and antioxidant capacity is positively correlated with muscle mass and strength.
Article
Geriatrics & Gerontology
Masroor Anwar, Rashmita Pradhan, Sharmistha Dey, Rahul Kumar
Summary: The population of older individuals is increasing rapidly, but only a small fraction among them is able to experience a healthy life. Aging, due to lack of physical exercise and oxidative stress, leads to sarcopenia and frailty. Sarcopenia, a component of frailty, is defined as age-related degenerative changes in skeletal muscle mass, strength, and quality. Although the loss of muscle strength and mass seems inevitable during aging, it can be partially prevented or overcome by understanding the underlying pathogenesis. Sirtuin protein has been found to increase longevity in various organisms, including worms and mammals. Physical exercise leads to an increase in the expression of sirtuin protein, which in turn strengthens muscle mass. Satellite cells play a role in muscle repair in a SIRT1-dependent manner. Additionally, SIRT1 improves insulin sensitivity and induces autophagy in aged mice. This paper discusses the potential role of sirtuins in sarcopenia and frailty, highlighting the pathways through which sirtuins can inhibit ROS production, inflammation, and mitochondrial dysfunctions, offering protection against frailty and sarcopenia. The critical role of sirtuins in the pathogenesis of sarcopenia and frailty could eventually lead to the development of novel interventions targeting sirtuins.
Article
Integrative & Complementary Medicine
Qun Xu, Jinyou Li, Ji Yang, Zherong Xu
Summary: In this study, novel prognostic biomarkers for muscle atrophy were identified using bioinformatics methods. The findings suggest that CUL3 and COPS5 may serve as potential prognostic biomarkers for muscle atrophy, associated with the ubiquitin-proteasome pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Physiology
Ling Ruan, Bharati Mendhe, Emily Parker, Andrew Kent, Carlos M. Isales, William D. Hill, Meghan McGee-Lawrence, Sadanand Fulzele, Mark W. Hamrick
Summary: This study discovered that the expression of lncRNA MALAT1 decreases with age in skeletal muscle, accompanied by an increase in miR-34a-5p expression. In vitro experiments showed that silencing MALAT1 increases miR-34a expression. Additionally, oxidative stress reduces MALAT1 expression, but this effect can be attenuated by p53 siRNA. Furthermore, MALAT1 silencing significantly increases TGF-beta 1 expression in C2C12 cells.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Nutrition & Dietetics
Filippo G. Di Girolamo, Nicola Fiotti, Ugo G. Sisto, Alessio Nunnari, Stefano Colla, Filippo Mearelli, Pierandrea Vinci, Paolo Schincariol, Gianni Biolo
Summary: There is a strong association between SARS-CoV-2 infection and decreased muscle mass and function, possibly due to the effects of inflammation, oxidative stress, hypoxia, and muscle fatigue. Aging and muscle wasting or sarcopenic obesity are risk factors for severe acute COVID-19 and long-COVID-19 syndrome.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Medicinal
Shanshan Wei, Wanjun Ma, Chuanhao Jiang, Jiaqin Liu, Jian Liu, Bikui Zhang, Wenqun Li
Summary: The present study aimed to demonstrate the effect and mechanism of hyperoside in Doxorubicin-induced cardiotoxicity. Hyperoside attenuated the cardiac dysfunction and cardiomyocyte apoptosis induced by Doxorubicin, mainly through inhibiting the NOXs/ROS/NLRP3 inflammasome signaling pathway, which is related to oxidative stress.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xin-xin Wang, Fan Wang, Guang-hui Mao, Jun-chao Wu, Mei Li, Rong Han, Jing She, Rong Zhang, Rui Sheng, Zhong Chen, Zheng-hong Qin
Summary: The study demonstrates that NADPH exerts better neuroprotective effects against ischemic stroke than NADH and edaravone, with a longer therapeutic time window and superior efficacy in ameliorating brain injury and metabolic stress.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Myung-Hun Lee, Jin-Ho Lee, Wan-Joong Kim, Seo Ho Kim, Sun-Young Kim, Han Sung Kim, Tack-Joong Kim
Summary: This study aimed to identify the antioxidant mechanism of linoleic acid (LA) in muscle atrophy caused by oxidative stress. The results showed that cells treated with LA were able to recover from oxidative damage, suggesting that LA may be a candidate substance for preventing muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Geriatrics & Gerontology
Francesca M. Alves, Scott Ayton, Ashley Bush, Gordon S. Lynch, Rene Koopman
Summary: Sarcopenia is an age-related condition characterized by the progressive loss of muscle mass and strength, leading to frailty, increased risk of hospitalization and mortality, and increased healthcare costs. The review outlines the mechanisms of iron accumulation in muscle and evaluates the evidence for the role of iron overload in sarcopenia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu Su, Bumsoo Ahn, Peter C. D. Macpherson, Rojina Ranjit, Dennis R. Claflin, Holly Van Remmen, Susan Brooks
Summary: Restoring CuZnSOD specifically in neurons of mice deficient in SOD can prevent muscle atrophy and loss of force, and restore mitochondrial function, ROS generation, and calcium handling levels. This suggests that intact neuronal function and innervation are key to maintaining excitation-contraction coupling and muscle mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lu-Lu Wu, Yue Zhang, Xiu-Zhen Li, Xin-Li Du, Ying Gao, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
Summary: Selective renal afferent denervation attenuated sympathetic activity, oxidative stress, vascular remodeling, and hypertension in spontaneously hypertensive rats (SHR).
Article
Biochemistry & Molecular Biology
Chiharuko Ushimoto, Shigeru Sugiki, Kenshirou Kunii, Shinya Inoue, Eriko Kuroda, Ryoko Akai, Takao Iwawaki, Katsuhito Miyazawa
Summary: Oxidative stress is a significant risk factor for calcium oxalate nephrolithiasis. This study investigates the association between oxidative stress response and stone formation through analyzing the response during different phases and observing the effect on crystal formation in mouse models. The findings suggest that the oxidative stress response via Keap1-Nrf2 pathway may contribute to crystal formation and could be a potential target for preventing and treating nephrolithiasis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
David Hernandez-Alvarez, Juana Rosado-Perez, Graciela Gavia-Garcia, Taide Laurita Arista-Ugalde, Itzen Aguiniga-Sanchez, Edelmiro Santiago-Osorio, Victor Manuel Mendoza-Nunez
Summary: Human aging is a complex process involving biochemical and molecular changes driven by hallmarks of aging such as oxidative stress, chronic inflammation, and telomere shortening. Sarcopenia, a disease associated with hallmarks of aging, significantly affects functionality and quality of life. The relationship between telomere length, sarcopenia, and age-related mortality is not well-studied. Moderate physical exercise has been found to have positive effects on sarcopenia, reducing oxidative stress and inflammation, and protecting telomeric DNA. This review presents the current state of knowledge on the impact of physical exercise on telomeric maintenance and repair mechanisms in sarcopenia.
Article
Geriatrics & Gerontology
Katelyn A. Russell, Rainer Ng, John A. Faulkner, Dennis R. Claflin, Christopher L. Mendias
EXPERIMENTAL GERONTOLOGY
(2015)
Article
Orthopedics
Christopher L. Mendias, Stuart M. Roche, Julie A. Harning, Max E. Davis, Evan B. Lynch, Elizabeth R. Sibilsky Enselman, Jon A. Jacobson, Dennis R. Claflin, Sarah Calve, Asheesh Bedi
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2015)
Article
Physiology
Dennis R. Claflin, Malcolm J. Jackson, Susan V. Brooks
FRONTIERS IN PHYSIOLOGY
(2015)
Article
Multidisciplinary Sciences
Stuart M. Roche, Jonathan P. Gumucio, Susan V. Brooks, Christopher L. Mendias, Dennis R. Claflin
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2015)
Article
Physiology
Anjali L. Saripalli, Kristoffer B. Sugg, Christopher L. Mendias, Susan V. Brooks, Dennis R. Claflin
JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Neurosciences
Fairouz Elsaeidi, Peter Macpherson, Elizabeth A. Mills, Jonathan Jui, John G. Flannery, Daniel Goldman
JOURNAL OF NEUROSCIENCE
(2018)
Article
Geriatrics & Gerontology
Rizwan Qaisar, Shylesh Bhaskaran, Pavithra Premkumar, Rojina Ranjit, Kavithalakshmi Satara Natarajan, Bumsoo Ahn, Kaitlyn Riddle, Dennis R. Claflin, Arlan Richardson, Susan Brooks, Holly Van Remmen
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2018)
Article
Geriatrics & Gerontology
Bumsoo Ahn, Rojina Ranjit, Pavithra Premkumar, Gavin Pharaoh, Katarzyna M. Piekarz, Satoshi Matsuzaki, Dennis R. Claflin, Kaitlyn Riddle, Jennifer Judge, Shylesh Bhaskaran, Kavithalakshmi Satara Natarajan, Erika Barboza, Benjamin Wronowski, Michael Kinter, Kenneth M. Humphries, Timothy M. Griffin, Willard M. Freeman, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Article
Medicine, Research & Experimental
James F. Markworth, Lemuel A. Brown, Eunice Lim, Carolyn Floyd, Jacqueline Larouche, Jesus A. Castor-Macias, Kristoffer B. Sugg, Dylan C. Sarver, Peter C. D. Macpherson, Carol Davis, Carlos A. Aguilar, Krishna Rao Maddipati, Susan Brooks
Article
Biochemistry & Molecular Biology
Yu Su, Bumsoo Ahn, Peter C. D. Macpherson, Rojina Ranjit, Dennis R. Claflin, Holly Van Remmen, Susan Brooks
Summary: Restoring CuZnSOD specifically in neurons of mice deficient in SOD can prevent muscle atrophy and loss of force, and restore mitochondrial function, ROS generation, and calcium handling levels. This suggests that intact neuronal function and innervation are key to maintaining excitation-contraction coupling and muscle mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Neurosciences
N. Pollock, P. C. Macpherson, C. A. Staunton, K. Hemmings, C. S. Davis, E. D. Owen, A. Vasilaki, H. Van Remmen, A. Richardson, A. McArdle, S. Brooks, M. J. Jackson
Summary: Comparing old mice with inducible neuron-specific deletion of Sod1 and whole-body Sod1 knockout mice with wild-type mice of different ages, it was found that the absence of neuronal Sod1 led to oxidative damage in motor neurons, resulting in loss of muscle mass and function and breakdown of neuromuscular junction.