期刊
IEEE TRANSACTIONS ON NANOBIOSCIENCE
卷 15, 期 8, 页码 828-834出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2016.2636869
关键词
Biosensors; plasmonic nanoparticles; photonic crystals; surface-enhanced Raman scattering
资金
- National Institutes of Health [1R03EB018893, 9R42ES024023]
- U.S. Department of Defense, Office of Naval Research, Synthetic Biology Program [N000141210313]
- NASA Ames Research Center [NNX14CA26P, NNX15CA12C]
- Universidad Nacional Autonoma de Mexico [DGAPA-IN109416]
- National Council of Science and Technology of Mexico [220626]
In this paper, we described a new type of bioenabled nano-plasmonic sensors based on diatom photonic crystal biosilica with in-situ growth silver nanoparticles and demonstrated label-free chemical and biological sensing based on surface-enhanced Raman scattering (SERs) from complex samples. Diatoms are photosynthetic marine micro-organisms that create their own skeletal shells of hydrated amorphous silica, called frustules, which possess photonic crystal-like hierarchical micro-&nanoscale periodic pores. Our research shows that such hybrid plasmonic-biosilica nanostructures formed by cost-effective and eco-friendly bottom-up processes can achieve ultra-high limit of detection for medical applications, food sensing, water/air quality monitoring and geological/space research. The enhanced sensitivity comes from the optical coupling of the guided-mode resonance of the diatom frustules and the localized surface plasmons of the silver nanoparticles. Additionally, the nanoporous, ultra-hydrophilic diatom biosilica with large surface-to-volume ratio can concentrate more analyte molecules to the surface of the SERS substrates, which can help to detect biomolecules that cannot be easily adsorbed by metallic nanoparticles.
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