期刊
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
卷 64, 期 4, 页码 1339-1347出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMTT.2016.2536021
关键词
Complex dielectric permittivity; conformal mapping; giant unilamellar vesicles (GUVs); microfluidics; microwave sensor
资金
- National Institutes of Health (NIH) [1K25GM100480-01A1]
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]
Novel techniques that enable reagent free detection and analysis of single cells are of great interest for the development of biological and medical sciences, as well as point-of-care health service technologies. Highly sensitive and broadband RF sensors are promising candidates for such a technique. In this work, we present a highly sensitive and tunable RF sensor, which is based on interference processes and built with a 100-nm slotline structure. The highly concentrated RF fields, up to similar to 1.76 x 10(7) V/m, enable strong interactions between giant unilamellar vesicles (GUVs) and fields for high-sensitivity operations. We also provide two modeling approaches to extract cell dielectric properties from measured scattering parameters. GUVs of different molecular compositions are synthesized and analyzed with the RF sensor at similar to 2, similar to 2.5, and similar to 2.8 GHz with an initial vertical bar S-21 vertical bar(min) of similar to -100 dB. Corresponding GUV dielectric properties are obtained. A one-dimensional scanning of single GUV is also demonstrated.
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