Article
Multidisciplinary Sciences
Linye Zhang, Qihong Jiang, Xiuming Wang, Amit Jaisi, Opeyemi Joshua Olatunji
Summary: This study evaluated the cardioprotective effects of Boesenbergia rotunda extract (BrE) against doxorubicin (DOX)-induced cardiotoxicity. The results demonstrated that BrE attenuated DOX-induced body and cardiac weight loss, prevented cardiac injury by mitigating histopathological alterations and reducing serum cardiac function enzymes. Furthermore, BrE alleviated cardiotoxicity by reducing oxidative stress, inflammation, and apoptosis in cardiac tissues.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Yang Li, Zhou Du, Tianyu Li, Xiaoke Ren, Yang Yu, Junchao Duan, Zhiwei Sun
Summary: This study aims to explore the pathogenesis of PM2.5-induced pulmonary fibrosis and the protective effect of MitoQ. The results show that PM2.5 exposure leads to inflammatory cell aggregation and pulmonary fibrosis in mouse lungs. Additionally, PM2.5 exposure also causes Collagen I/III overproduction, EMT, and activation of the TGF-(i1/Smad2 pathway. These changes were partially alleviated by MitoQ treatment.
Review
Biochemistry & Molecular Biology
Xiaochen Xie, Ye Zhang, Zhuo Wang, Shanshan Wang, Xiaoyou Jiang, Hongyan Cui, Tingting Zhou, Zheng He, Hao Feng, Qiqiang Guo, Xiaoyu Song, Liu Cao
Summary: ROS, initially considered pathological, are now recognized as signaling intermediates that promote cellular adaptation to stress through autophagy regulation. ATM protein, activated by ROS, is involved in autophagy regulation, maintaining genome stability and triggering cytoplasmic autophagy as a ROS sensor.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Ana Mesquita, James Glenn, Andreas Jenny
Summary: Autophagy is a major catabolic pathway crucial for cellular homeostasis and stress response. Endosomal microautophagy can be induced under stress conditions and regulated by various signaling pathways, suggesting its important role in disease prevention.
Article
Biochemistry & Molecular Biology
Yanmei Li, Dan Hao, Danfeng Wei, Yue Xiao, Lian Liu, Xiaoxue Li, Lian Wang, Yu Gan, Wei Yan, Bowen Ke, Xian Jiang
Summary: This study investigated the photoprotective effects of CBD against UVB-induced skin damage. The results showed that CBD alleviated cytotoxicity, apoptosis, and cell cycle arrest caused by UVB. CBD also decreased the production of reactive oxygen species and modulated the expression of antioxidant-related proteins. Additionally, CBD mitigated UVB-induced cytotoxicity by activating autophagy. The study also demonstrated that a cream containing 5% CBD was effective in reducing photodamage in a murine model.
Article
Pharmacology & Pharmacy
Tarek Khamis, Abdelalim F. Abdelalim, Ahmed A. Saeed, Nagah M. Edress, Alaa Nafea, Huda F. Ebian, Reem Algendy, Doaa M. Hendawy, Ahmed Hamed Arisha, Somia Hassan Abdallah
Summary: The study revealed that intraperitoneally transplanted Br-MSCs homed to the diabetic islet, improving fasting blood glucose, serum insulin level, and pancreatic oxidative stress, and modulated various molecular pathways involved in beta-cell dysfunction, indicating their potential as a new insight in beta cell regenerative therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenjing Liu, Zhonggui Gong, Kanglei Zhang, Wenxuan Dong, Hui Zou, Ruilong Song, Jianchun Bian, Jiaqiao Zhu, Gang Liu, Zongping Liu
Summary: This study found that Paeonol can alleviate Cd-induced renal cytotoxicity by alleviating oxidative stress, inhibiting inflammatory responses, and restoring autophagy, potentially serving as a new candidate drug to treat Cd-induced nephrotoxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Paritosh Mondal, Pallab Shaw, Arpan Dey Bhowmik, Arindam Bandyopadhyay, Muthammal Sudarshan, Anindita Chakraborty, Ansuman Chattopadhyay
Summary: This study found that the combined exposure of arsenic and fluoride had minimal impact on the female zebrafish brain, with lower oxidative stress response and tissue damage, indicating an antagonistic effect between the two toxicants.
Article
Environmental Sciences
Solomon E. Owumi, Eseroghene S. Najophe, Moses T. Otunla
Summary: Co-treatment with indole-3-propionic acid (IPA) can effectively reduce oxidative stress, pro-inflammatory responses, DNA damage, and apoptosis induced by chlorpyrifos (CPF) in the liver and kidneys of rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Xiaoming Liu, Pengxiang Ge, Zhenyu Lu, Rongying Yang, Zhengjiang Liu, Fen Zhao, Mindong Chen
Summary: This study aimed to investigate the reproductive toxicity of PM2.5 to Caenorhabditis elegans (C. elegans) and its underlying mechanisms. The results showed that exposure to PM2.5 caused reproductive dysfunction, germ cell apoptosis, and DNA damage in C. elegans, possibly through the induction of reactive oxygen species (ROS). Furthermore, heavy metals in PM2.5 were identified as important contributors to the reproductive toxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Food Science & Technology
Goran Gajski, Marko Geric, Ivone Jakasa, Ines Peremin, Ana-Marija Domijan, Marijana Vucic Lovrencic, Sanja Kezic, Martina Bituh, Vanessa Moraes de Andrade
Summary: The health benefits of a vegetarian diet are still debated, but it may have positive effects on oxidative stress and inflammation, while its impact on immune biomarkers is inconclusive.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Environmental Sciences
Zhihui Tian, Haohao Liu, Xinghai Chen, Michael D. Losiewicz, Rui Wang, Xingde Du, Bingqian Wang, Ya Ma, Shiyu Zhang, Linjia Shi, Xing Guo, Yongshui Wang, Bingyu Zhang, Shumeng Yuan, Xin Zeng, Huizhen Zhang
Summary: The study revealed that oxidative stress induced by MC-LR can activate the DNA damage-mediated ATM/p53 signaling pathway to induce autophagy in male germ cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Merve Becit, Sule Cilekar, Mustafa Mert Basaran, Halit Bugra Koca, Sefa Celik, Sevtap Aydin Dilsiz
Summary: Workers in marble processing plants are at high risk of exposure to marble dust containing silica, which may result in immunotoxic and genotoxic effects. Oxidative stress and immune system parameters were significantly affected in workers exposed to marble dust.
ENVIRONMENTAL RESEARCH
(2021)
Article
Immunology
Siyue He, Jing Xia, Huijie Jia, Qianlong Dai, Cui Chen, Yue Zhou, Xiao Bo Wang
Summary: 5-Fluorouracil (5-FU) is an important drug for colorectal cancer patients, but it causes severe side effects like chemotherapy intestinal mucositis (CIM). The therapeutic role of peficitinib, a Janus Kinase (JAK) inhibitor, in CIM is still unclear. This study found that peficitinib alleviates mucositis by reducing aging, inflammation, and oxidative stress, and enhances the anticancer activity of 5-FU. Rating: 8 points.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Hongrui Guo, Heng Yin, Zhicai Zuo, Zhuangzhi Yang, Yue Yang, Ling Wei, Hengmin Cui, Huidan Deng, Xia Chen, Jian Chen, Yanqiu Zhu, Ping Ouyang, Yi Geng, Zongjun Du, Huaqiao Tang, Fengyuan Wang, Jing Fang
Summary: The study found that nickel-mediated renal injury is associated with oxidative stress-induced apoptosis and autophagy. NAC, as an effective antioxidant, can suppress nickel-induced oxidative stress and alleviate kidney damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
