Article
Gastroenterology & Hepatology
Yoosun Cho, Yoosoo Chang, Seungho Ryu, Sarah H. Wild, Christopher D. Byrne
Summary: Reclassification of NAFLD as MAFLD has been proposed, and the risk of developing type 2 diabetes in NAFLD-only subjects remains unclear. This study compared the risk of incident T2D in individuals with NAFLD-only and MAFLD to those without fatty liver, and found that both NAFLD-only and MAFLD were associated with an increased risk of T2D. The risk was higher in women than in men, and the association was consistent across all subgroups.
LIVER INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Pai-Chi Teng, Daniel Q. Huang, Ting-Yi Lin, Mazen Noureddin, Ju Dong Yang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease caused by insulin resistance. Diabetes increases the risk of liver disease progression and cirrhosis development in NAFLD patients, as well as the risk of hepatocellular carcinoma (HCC). Diabetes promotes hepatocarcinogenesis through inflammatory cascades, resulting in genomic instability, cellular proliferation, and apoptosis inhibition.
Article
Oncology
Jae Seung Lee, Dong Hyun Sinn, Soo Young Park, Hye Jung Shin, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Joo Hyun Oh, Jung Il Lee, Seung Up Kim
Summary: A new liver stiffness-based risk prediction model for the development of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease showed acceptable performance in both internal and external validation, demonstrating its usefulness in predicting the risk of HCC development in NAFLD patients.
Article
Gastroenterology & Hepatology
Dong Hyun Sinn, Danbee Kang, Sung Chul Choi, Yun Soo Hong, Di Zhao, Eliseo Guallar, Yewan Park, Juhee Cho, Geum-Youn Gwak
Summary: The clinical implications of nonalcoholic fatty liver disease (NAFLD) in subjects who fulfill the diagnostic criteria of metabolic (dysfunction)-associated fatty liver disease (MAFLD) are unknown.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Yi-Chuan Yu, Pedram Paragomi, Renwei Wang, Feiran Liang, Hung N. N. Luu, Jaideep Behari, Jian-Min Yuan
Summary: This study examined the association between serum magnesium levels and the risk of HCC among patients with NAFLD. The results showed that higher levels of serum magnesium were significantly associated with a decreased risk of HCC among patients with NAFLD.
Review
Oncology
Tomomi Kogiso, Katsutoshi Tokushige
Summary: The incidence of NAFLD-related HCC is increasing, emphasizing the need for effective screening. Revised guidelines in Japan propose new management and surveillance strategies for NAFLD/NASH. Advanced fibrosis and lifestyle-related diseases are associated with HCC development.
Review
Gastroenterology & Hepatology
Yuri Cho, Bo Hyun Kim, Joong-Won Park
Summary: The incidence of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD) is increasing globally, including Asia. Compared to virus-related HCC, most patients with NAFLD-related HCC are diagnosed at a late stage and older age due to lack of HCC surveillance. This review provides an overview of the mechanism of hepatocarcinogenesis in NAFLD, preventive strategies for NAFLD-related HCC, and surveillance strategies for patients with NAFLD.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Biyao Zou, Michelle C. Odden, Mindie H. Nguyen
Summary: Recent evidence suggests potential clinical benefits of statin in cancer chemoprevention and treatment. This study aimed to investigate the association between statin initiation and the risk of HCC among patients with NAFLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Maria Corina Plaz Torres, Ariel Jaffe, Rachel Perry, Elisa Marabotto, Mario Strazzabosco, Edoardo G. Giannini
Summary: Type 2 diabetes mellitus is a recognized risk factor for HCC in patients with liver disease, and the choice of diabetic medication in these patients can have complex implications for potential hepatic carcinogenesis. Metformin may reduce the risk of HCC, while evidence for other diabetic medications, especially newer agents, is limited and inconsistent. Further research is needed to understand the potential effects of different diabetic agents on liver cancer tumorigenesis.
Review
Multidisciplinary Sciences
George Agyapong, Farzaneh Dashti, Bubu A. A. Banini
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and a leading indication for liver transplantation in the United States. This manuscript provides an overview of NAFLD risk factors, natural history, diagnosis, and current management strategies.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Immunology
Nuria Barbarroja, Miriam Ruiz-Ponce, Laura Cuesta-Lopez, Carlos Perez-Sanchez, Chary Lopez-Pedrera, Ivan Arias-de La Rosa, Eduardo Collantes-Estevez
Summary: Liver disease is a significant cause of increased morbidity and mortality worldwide. Inflammation and the accumulation of fat in the liver can lead to hepatic damage, progressing to fibrosis and eventually cirrhosis, which are closely associated with cardiovascular disease. Patients with inflammatory conditions like rheumatoid arthritis and psoriatic arthritis have a higher risk of liver disease compared to the general population, possibly due to chronic inflammation, autoimmunity, treatments, and metabolic deregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Yifan Sun, Liang Hong, Zhe Huang, Lihong Wang, Yanqin Xiong, Shuhang Zong, Rui Zhang, Jun Liu, Shufei Zang
Summary: The study found that NAFLD, fibrosis, and type 2 diabetes had an additive interaction on chronic kidney disease incidence. The increased risk of NAFLD fibrosis was closely associated with chronic kidney disease in elderly patients with type 2 diabetes. FIB-4 performed better than NFS in predicting chronic kidney disease development.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Gastroenterology & Hepatology
Simona Cernea, Danusia Onisor
Summary: Liver cancer, specifically hepatocellular carcinoma (HCC), is a common type of cancer worldwide. In addition to viral infections and certain liver diseases, other risk factors such as old age, obesity, insulin resistance, and type 2 diabetes also contribute to the occurrence of HCC. Screening for HCC in nonalcoholic fatty liver disease (NAFLD) patients is still lacking, and identifying individuals who progress to HCC without cirrhosis is a challenge. Lifestyle changes and pharmacological interventions may play a protective role in preventing NAFLD/NASH-associated HCC, but more research is needed to understand the relationship.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Food Science & Technology
Seyed Mohammad Mazloomi, Mohammad Samadi, Hajar Davarpanah, Siavash Babajafari, Cain C. T. Clark, Zohreh Ghaemfar, Mojtaba Rezaiyan, Abdolhamid Mosallanezhad, Maryam Shafiee, Hosein Rostami
Summary: The study suggests that Spirulina may improve nonalcoholic fatty liver disease by modifying liver enzymes, oxidative stress, and some lipid profiles, while showing no effect on anthropometric characteristics and blood pressure.
FOOD SCIENCE & NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Eunji Ko, Eileen L. Yoon, Dae Won Jun
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, with an estimated prevalence of 25%. NAFLD is a major cause of liver cirrhosis, hepatocellular carcinoma, and death. Cardiovascular disease risk also increases with NAFLD severity.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
J. R. Kramer, H. B. El-Serag, T. J. Taylor, D. L. White, S. M. Asch, S. M. Frayne, Y. Cao, D. L. Smith, F. Kanwal
JOURNAL OF VIRAL HEPATITIS
(2017)
Article
Gastroenterology & Hepatology
J. R. Kramer, A. Puenpatom, K. F. Erickson, Y. Cao, D. Smith, H. B. El-Serag, F. Kanwal
JOURNAL OF VIRAL HEPATITIS
(2018)
Article
Gastroenterology & Hepatology
Hashem B. El-Serag, Israel C. Christie, Amy Puenpatom, Diana Castillo, Fasiha Kanwal, Jennifer R. Kramer
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Infectious Diseases
J. R. Kramer, C. Hartman, D. L. White, K. Royse, P. Richardson, A. P. Thrift, S. Raychaudhury, R. Desiderio, D. Sanchez, E. Y. Chiao
Article
Gastroenterology & Hepatology
Fasiha Kanwal, Jennifer R. Kramer, Steven M. Asch, Yumei Cao, Liang Li, Hashem B. El-Serag
Article
Gastroenterology & Hepatology
Fasiha Kanwal, Jennifer R. Kramer, Liang Li, Jianliang Dai, Yamini Natarajan, Xian Yu, Steven M. Asch, Hashem B. El-Serag
Article
Gastroenterology & Hepatology
Yamini Natarajan, Jennifer R. Kramer, Xian Yu, Liang Li, Aaron P. Thrift, Hashem B. El-Serag, Fasiha Kanwal
Article
Otorhinolaryngology
Jose P. Zevallos, Jennifer R. Kramer, Vlad C. Sandulache, Sean T. Massa, Christine M. Hartman, Angela L. Mazul, Benjamin M. Wahle, Sophie P. Gerndt, Erich M. Sturgis, Elizabeth Y. Chiao
Summary: The study found that the incidence of oropharyngeal squamous cell carcinoma is increasing among all racial and age cohorts in the VA population. Smoking rates remain high among Veterans with OPSCC, and improvements in survival rates are slower than those reported in the general population.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Gastroenterology & Hepatology
Hannes Hagstrom, Leon A. Adams, Alina M. Allen, Christopher D. Byrne, Yoosoo Chang, Henning Gronbaek, Mona Ismail, Peter Jepsen, Fasiha Kanwal, Jennifer Kramer, Jeffrey V. Lazarus, Michelle T. Long, Rohit Loomba, Philip N. Newsome, Ian A. Rowe, Seungho Ryu, Jorn M. Schattenberg, Marina Serper, Nick Sheron, Tracey G. Simon, Elliot B. Tapper, Sarah Wild, Vincent Wai-Sun Wong, Yusuf Yilmaz, Shira Zelber-Sagi, Fredrik Aberg
Summary: By reaching consensus on ICD codes for EHR-based research, the generalizability and comparability of research results can be improved. The expert panel achieved high agreement and provided a detailed list of ICD codes for exposures and outcomes, along with suggestions for addressing common methodological issues.
Letter
Gastroenterology & Hepatology
Jennifer R. Kramer, Yamini Natarajan, Jianliang Dai, Xian Yu, Liang Li, Hashem B. El-Serag, Fasiha Kanwal
Article
Oncology
Yanhong Liu, Jennifer R. Kramer, Vlad C. Sandulache, Robert Yu, Guojun Li, Liang Chen, Zenab I. Yusuf, Yunling Shi, Saiju Pyarajan, Spyros Tsavachidis, Li Jiao, Michelle L. Mierzwa, Elizabeth Chiao, Yvonne M. Mowery, Andrew Shuman, Sanjay Shete, Andrew G. Sikora, Donna L. White
Summary: Inherited variations in immune system genes are significantly associated with susceptibility to head and neck cancer, regardless of whether it is HPV-driven or not. This finding highlights the importance of immune gene variants in modulating HNSCC risk.
Article
Gastroenterology & Hepatology
Jennifer R. Kramer, Yumei Cao, Liang Li, Donna Smith, Jagpreet Chhatwal, Hashem B. El-Serag, Fasiha Kanwal
Summary: This study examined the risk factors for hepatocellular carcinoma (HCC) in patients with virologically cured hepatitis C virus (HCV) infection, and found that the risk factors differed between patients with and without cirrhosis, and some factors evolved over time. These factors can help with risk stratification and decisions on HCC surveillance in patients with cured HCV.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Health Care Sciences & Services
Felicia Skelton, Lindsey Ann Martin, Charlesnika T. Evans, Jennifer Kramer, Larissa Grigoryan, Peter Richardson, Mark E. Kunik, Ivy Oiyee Poon, S. Ann Holmes, Barbara W. Trautner
JMIR RESEARCH PROTOCOLS
(2019)
Article
Gastroenterology & Hepatology
M. Lin, J. Kramer, D. White, Y. Cao, S. Tavakoli-Tabasi, S. Madu, D. Smith, S. M. Asch, H. B. El-Serag, F. Kanwal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2017)