Article
Oncology
Ambreen Muhammed, Claudia Angela Maria Fulgenzi, Sirish Dharmapuri, Matthias Pinter, Lorenz Balcar, Bernhard Scheiner, Thomas U. Marron, Tomi Jun, Anwaar Saeed, Hannah Hildebrand, Mahvish Muzaffar, Musharraf Navaid, Abdul Rafeh Naqash, Anuhya Gampa, Umut Ozbek, Junk-Yi Lin, Ylenia Perone, Bruno Vincenzi, Marianna Silletta, Anjana Pillai, Yinghong Wang, Uqba Khan, Yi-Hsiang Huang, Dominik Bettinger, Yehia I. Abugabal, Ahmed Kaseb, Tiziana Pressiani, Nicola Personeni, Lorenza Rimassa, Naoshi Nishida, Luca Di Tommaso, Masatoshi Kudo, Arndt Vogel, Francesco A. Mauri, Alessio Cortellini, Rohini Sharma, Antonio D'Alessio, Celina Ang, David J. Pinato
Summary: The study found that blood inflammatory markers can predict the survival and response of patients with advanced hepatocellular carcinoma treated with immunotherapy. Neutrophile to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were identified as independent prognostic factors.
Article
Multidisciplinary Sciences
Tomasz Urbanowicz, Anna Olasinska-Witniewska, Michel Michalak, Bartlomiej Perek, Ahmed Al-Imam, Michal Rodzki, Anna Witkowska, Ewa Straburzynska-Migaj, Michal Bocianski, Marcin Misterski, Maciej Lesiak, Marek Jemielity
Summary: This study aimed to investigate the predictive role of preoperative inflammatory indexes in off-pump coronary artery bypass grafting on long-term survival. The findings suggest that a preoperative value of systemic inflammatory response index (SIRI) above 1.27 is associated with worse long-term prognosis after off-pump surgery.
Article
Medicine, General & Internal
Flaviu Moldovan, Adrian Dumitru Ivanescu, Pal Fodor, Liviu Moldovan, Tiberiu Bataga
Summary: This study aimed to determine the correlation between blood-count-derived biomarkers such as NLR, PLR, MLR, and SII and the level of aggression sustained by elderly patients during surgical procedures for hip fractures. A retrospective cohort study included 129 patients aged over 70 diagnosed with acute hip fractures. The results showed significant differences in various parameters between patients with different fracture locations and treatments. The postoperative NLR, PLR, SII, and duration of surgery were found to be independently related to the invasiveness of the procedures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Dalia E. Yousif, Xiaoling Ye, Stefano Stuard, Juan Berbessi, Adrian M. Guinsburg, Len A. Usvyat, Jochen G. Raimann, Jeroen P. Kooman, Frank M. van der Sande, Neill Duncan, Kevin J. Woollard, Rupert Bright, Charles Pusey, Vineet Gupta, Joachim H. Ix, Peter Kotanko, Rakesh Malhotra
Summary: This study investigated the longitudinal changes in inflammatory markers in hemodialysis patients and their relationship with survival time. The results showed a distinct biphasic pattern of change in inflammatory markers in patients who died, while a sustained decline in inflammation was observed in survivors.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Surgery
Francesca Savioli, Elizabeth S. Morrow, Ross D. Dolan, Laszlo Romics, Alison Lannigan, Joanne Edwards, Donald C. McMillan
Summary: Through a systematic review and meta-analysis, it was found that preoperative circulating markers of the systemic inflammatory response, such as NLR, dNLR, LMR, PLR, and CRP, may serve as prognostic markers in primary operable breast cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Review
Endocrinology & Metabolism
Elisa Giannetta, Anna La Salvia, Laura Rizza, Giovanna Muscogiuri, Severo Campione, Carlotta Pozza, Annamaria Anita LIvia Colao, Antongiulio Faggiano
Summary: Given the increasing incidence of neuroendocrine neoplasms (NENs) over the past few decades, there is an urgent need for a better understanding of their pathophysiological bases and the identification of innovative NEN biomarkers. Inflammatory biomarkers have been identified as critical in various tumors, including NENs, with a bidirectional relationship between chronic inflammation and the development of NENs reported. Studies have shown promising potential for circulating inflammatory markers such as NLR, PLR, cytokines, and tissue inflammatory markers (PD-1/PD-L1) in the management of NENs, although further validation and clarification of their utility is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Health Care Sciences & Services
Vlad Vunvulea, Ovidiu Aurelian Budisca, Emil Marian Arbanasi, Adrian Vasile Muresan, Eliza Mihaela Arbanasi, Klara Brinzaniuc, Raluca Niculescu, Iuliu Gabriel Cocuz, Adrian Dumitru Ivanescu, Ioana Halmaciu, Lucian Marginean, Reka Kaller, Eliza Russu, Bogdan Andrei Suciu
Summary: This study aimed to investigate the predictive role of inflammatory biomarkers and underlying risk factors in abdominal trauma patients for the risk of acute kidney insufficiency (AKI) and mortality. The results showed that high levels of certain inflammatory biomarkers at admission can effectively predict adverse outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Liangbo Li, Zhanbo Li, Xuanqi Feng, Zhao Yang, Nenghao Jin, Liang Zhu, Xiaoyi Zang, Lejun Xing, Yipeng Ren, Haizhong Zhang
Summary: This study evaluated the prognostic significance of the preoperative systemic inflammation index, platelet-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio in patients with squamous carcinoma of the tongue. The results showed significant associations between these indices and sex, tissue grade, tumor location, and lymph nodes metastases. Patients with lower values of the indices had longer overall survival. Age, lymph node metastases, and neutrophil-to-lymphocyte ratio were identified as independent predictors of overall survival.
Article
Oncology
Zhenhua Liu, Haijue Ge, Zhilong Miao, Shoupeng Shao, Hongtai Shi, Congsong Dong
Summary: The systemic inflammation response index (SIRI) is a reliable indicator for evaluating the prognosis of patients with operable gastric cancer. The dynamic change in SIRI before and after surgery is significantly related to the prognosis of patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Qing Li, Jianfeng Xie, Yingzi Huang, Songqiao Liu, Fengmei Guo, Ling Liu, Yi Yang
Summary: Leukocytes play an essential role in immune function during sepsis, and our study showed that lymphocyte counts are associated with survival rates in critically ill patients with septic shock. The dynamics of leukocytes within the first 3 days of ICU admission can serve as a valuable prognostic marker for septic shock patients in the ICU.
Article
Medicine, General & Internal
Ewelina A. Dziedzic, Jakub S. Gasior, Agnieszka Tuzimek, Waclaw Kochman
Summary: Women with coronary artery disease (CAD) are often misdiagnosed and undertreated. This study suggests a potential connection between acute coronary syndrome (ACS) and inflammation in women, and explores the relationship between inflammatory markers and traditional CAD risk factors. The findings indicate that these inflammatory markers may serve as new risk factors for CAD in elderly women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Supriya Mishra, Lynn Johnson, M. P. Gazala, Sheetal Dahiya, Waheda Rahman, V. S. Sreeraj
Summary: The study found that SII is associated with generalized stage III grade C periodontitis in young adults and can predict its occurrence. This multicentered, double-blind, hospital-based case-control clinical study showed that SII has fair predictive validity in detecting the disease, but is not superior to NLR.
Article
Health Care Sciences & Services
Ruei-Ti Ke, Cheng-Shyuan Rau, Ting-Min Hsieh, Sheng-En Chou, Wei-Ti Su, Shiun-Yuan Hsu, Ching-Hua Hsieh, Hang-Tsung Liu
Summary: This study identified that a higher lymphocyte count, lower platelet count, and lower PLR were associated with a higher risk of death in ICU trauma patients.
Article
Medicine, General & Internal
Hulya Albayrak
Summary: This study found that the neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) can be important indicators for evaluating the treatment of psoriasis patients. The SII showed strong positive correlations with the NLR, NMR, and PLR. TNF-α blockers such as Adalimumab, etanercept, and infliximab were found to be especially effective on PLR, NLR, and NMR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Transplantation
Hasan H. Yeter, Ozant Helvaci, Berfu Korucu, Sevim Gonen, Galip Guz, Ulver Derici
Summary: This study investigated the relationship between single-nucleotide polymorphisms of the klotho gene and bone diseases after kidney transplant. It also aimed to identify risk factors for the development of bone disease. Results showed that a specific polymorphism in the klotho gene was significantly associated with persistent hyperparathyroidism.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Hasan H. Yeter, Ebru Gok Oguz, Omer F. Akcay, Refika Karaer, Emre Yasar, Murat Duranay, Mehmet D. Ayli, Galip Guz
Summary: This study evaluated symptoms, changes in laboratory findings, and the impact of depression in PD patients during the COVID-19 pandemic. Results showed that depression was associated with symptoms such as dyspnea, weight gain, and fatigue. The study also indicated that PD is a reliable and successful form of dialysis, with RM-APD potentially providing more stable bone-mineral metabolism.
SEMINARS IN DIALYSIS
(2021)
Article
Surgery
Omer Faruk Akcay, Haci Hasan Yeter, Deniz Karcaaltincaba, Merih Bayram, Galip Guz, Yasemin Erten
Summary: The study investigated obstetric and graft outcomes in 29 pregnancies of 18 female kidney transplant recipients. It found that pregnancy after kidney transplantation is associated with high rates of maternal and fetal complications, and may lead to sustained decline of graft function compared to recipients without pregnancy history.
CLINICAL TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Emre Yasar, Hasan Selcuk Ozger, Haci Hasan Yeter, Cigdem Yildirim, Zakir Osmanov, Taha Enes Cetin, Omer Faruk Akcay, Neslihan Bukan, Ulver Derici
Summary: The study found that in patients with COVID-19 infection, even without developing acute kidney injury, the level of urinary Kidney Injury Molecule-1 (uKIM-1) significantly increased and was correlated with other biochemical markers. In some patients, proteinuria regressed to normal levels after several weeks, despite not meeting the criteria for AKI.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Oktay Halit Aktepe, Fatma Gundogdu, Kemal Kosemehmetoglu, Haci Hasan Yeter, Sercan Aksoy, Deniz Can Guven, Taha Koray Sahin, Deniz Yuce, Neyran Kertmen, Omer Dizdar, Suayib Yalcin, Mustafa Erman
Summary: The expression of THSD7A is associated with overall survival of metastatic RCC patients receiving targeted therapy, suggesting an important link between THSD7A expression and resistance to targeted therapy.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Urology & Nephrology
Hasan Haci Yeter, Omer Faruk Akcay
Summary: This study evaluated 295 YouTube videos and found that videos sourced from universities or societies had higher quality and were more suitable for healthcare providers to watch. However, only a few videos mentioned that PD can maintain residual kidney function longer compared to haemodialysis. It is recommended that universities and societies should upload easy-to-understand PD information videos to increase patients' awareness and penetrance.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Urology & Nephrology
Berfu Korucu, Hasan Yeter, Sevim Gonen, Mehmet Kursat Derici, Claudio Ronco, Ulver Derici
Summary: This study investigates the effects of medium cut-off dialyzers on S100A12 and sRAGE levels in HD patients. The results suggest that prolonged use of MCO dialyzers is associated with better S100A12 and sRAGE levels.
SEMINARS IN DIALYSIS
(2023)
Article
Engineering, Biomedical
Berfu Korucu, Serpil Muge Deger, Hasan Yeter, Omer Faruk Akcay, Yagiz Cimen, Burak Dogan, Mehmet Kiraci, Ahmet Giritlioglu, Seher Kanber, Meltem Busra Erdemir, Seda Cicekli, Galip Guz
Summary: This study demonstrates that the characteristics of the peritoneal membrane may change over time in some patients undergoing PD treatment, despite low peritonitis frequencies and similar baseline characteristics, which may be significantly affected by systemic inflammation.
Article
Hematology
Hasan Haci Yeter, Aybuke Izgi, Saliha Yildirim, Omer Faruk Akcay, Ulver Derici
Summary: Initiating early-start PD is comparable with conventional-start PD, and it may be an alternative dialysis modality to avoid bloodstream infections in suitable patients.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Immunology
Omer Faruk Akcay, Haci Hasan Yeter, Yasemin Unsal, Emre Yasar, Sevim Gonen, Ulver Derici
Summary: A study in Turkish kidney transplant recipients and wait listed patients found that HLA allele polymorphisms may be associated with susceptibility to SARS-CoV-2 infection and mortality. They identified significant associations between HLA-B*49 and HLA-DRB1*14 with SARS-CoV-2 infection, as well as HLA-C*03 with COVID-19 mortality.
Article
Urology & Nephrology
Haci Hasan Yeter, Ceren Karacalik, Esra Eraslan, Halil Durantas, Omer Faruk Akcay, Kursat Derici, Ulver Derici
Summary: Patients undergoing peritoneal dialysis (PD) have a higher level of fluid overload and arterial stiffness compared to those undergoing hemodialysis (HD) and healthy individuals. Hemodialysis patients have higher levels of soluble suppression of tumorigenicity 2 (sST2) than PD patients and the control group. The choice of dialysis modality and duration, as well as the residual renal function, are associated with the levels of sST2 in dialysis patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Meeting Abstract
Transplantation
Berfu Korucu, Hasan Haci Yeter, Omer Faruk Akcay, Galip Guz
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Hasan H. Yeter, Ulver Derici, Turgay Arinsoy, Kadriye Altok, Yasemin Erten, Galip Guz
Summary: The study found that eculizumab treatment is crucial for the survival of aHUS patients. Treatment discontinuation may be considered at least six months after hematologic remission in patients with stable renal function or no expectancy for renal survival. Drug-associated cases seem less likely to develop long-term disease relapse.
ROMANIAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Oktay Halit Aktepe, Taha Koray Sahin, Gurkan Guner, Deniz Can Guven, Haci Hasan Yeter, Olcay Kurtulan, Ibrahim Hanifi Ozercan, Omer Dizdar, Suayib Yalcin
Summary: The study revealed that negative staining for THSD7A was associated with invasive pathologic determinants in AOM-induced CRC in rats, as evidenced by the inverse correlation with Ki-67 expression and tumor grade. Additionally, higher Ki-67 expression was linked to higher tumor grade, presence of lymphatic invasion, and higher T stage in the AOM-induced CRC model.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2021)