期刊
FOOD CHEMISTRY
卷 369, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.130911
关键词
Grass carp (Ctenopharyngodon idella); Apoptosis; Caspase; Inflammation; Cytokines
资金
- China Agriculture Research System of MOF and MARA
- Natural ScienceFoundation of Jiangsu Province [BK20190588]
- National Natural Sci-ence Foundation of China [NSFC 31701677]
- Jiangsu Agricultural In-dustry Technology System [JATS [2020] 454]
- Fundamental Research Funds for the Central Universities [JUSRP12006]
This study found that the transcriptional regulation of multiple cytokines during postmortem alteration in fish muscle positively affects triggering apoptosis, potentially through the regulation of various pro-apoptotic and anti-apoptotic mediators.
Postmortem alteration by apoptosis has significant effects on flesh quality. Currently, the information necessary to understand the apoptotic behavior and the molecular mechanisms during postmortem alteration in fish muscle is still lacking. Activation of apoptosis and the cytokines involved in regulating apoptosis in fish muscle were evaluated during postmortem condition at 4 degrees C for 5 days in terms of apoptotic morphology changes, nucleus DNA fragmentation, caspases activation and related gene expressions. The triggering apoptotic mechanisms associated with multiple cytokines transcriptional levels showed that the up-regulated pro-apoptotic mediators [IFN-gamma 2, TNF-alpha, IL-6, IL-1 beta, IL-17D, IL-12p35 and IL-10 (except IL-15)] and the down-regulated anti-apoptotic mediators of [IL-8 and IL-11 (except TGF-beta and IL-4)] both regulated apoptosis at early stage, which were regulated by NF -KB and TOR, respectively. Results suggested that transcriptional regulation of multiple cytokines produce a positive outcome on triggering apoptosis.
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