Article
Environmental Sciences
Ebenezer Ashun, Umair Ali Toor, Hyuck Soo Kim, Kwon-Rae Kim, Se Jin Park, Sunhee Hong, Sang-Eun Oh
Summary: This study evaluated the toxicities of low/uncontaminated and contaminated field soils with varying geophysical and physicochemical characteristics based on oxygen consumption of sulfur-oxidizing bacteria. Contaminated soils were found to be toxic, showing significant inhibition of oxygen consumption. The study established a rapid toxicity assessment method for contaminated field soils.
Article
Environmental Sciences
Fida Hussain, Ebenezer Ashun, Sokhee P. Jung, Taeyoung Kim, Sang-Hun Lee, Dong-Jin Kim, Sang-Eun Oh
Summary: This study assessed the toxicity of uncontaminated and contaminated soils with different physicochemical properties and contamination levels using a bioassay of immobilized microalgae. The results showed that elevated concentrations of heavy metals and organic contaminants in the contaminated soils induced higher inhibitory levels.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Review
Toxicology
Jaeseong Jeong, Donghyeon Kim, Jinhee Choi
Summary: This article introduces the new approach methodologies (NAMs) that have emerged in the 21st century to minimize the use of experimental animals, using advanced technology. The ToxCast/Tox21 database aims to evaluate the adverse effects of chemicals and transform the toxicity assessment paradigm. It provides extensive data for chemical prioritization and toxicity prediction. The article explores the database overview, research trends, and potential applications and limitations in chemical risk assessment.
TOXICOLOGY IN VITRO
(2022)
Article
Environmental Sciences
Maria Jesus Gonzalez-Pabon, Eduardo Corton, Federico Figueredo
Summary: This study overcame three primary bottlenecks in the practical use of microbial fuel cell (MFC) analytical devices. By utilizing planktonic bacteria as biorecognition agents, a paper-based MFC toxicity test was developed, showing promising future for rapid and easy-to-use MFC devices in the market.
Article
Environmental Sciences
Konstantin Pikula, Mariya Tretyakova, Alexander Zakharenko, Seyed Ali Johari, Sergey Ugay, Valery Chernyshev, Vladimir Chaika, Tatiana Kalenik, Kirill Golokhvast
Summary: Vehicle emission particles (VEPs) pose a significant threat to marine aquatic organisms, with high concentrations causing harmful effects on microalgae and crustaceans. The combination of high submicron particle numbers and high PAH concentrations had the highest toxic effect on all tested species.
Article
Chemistry, Multidisciplinary
Ilabahen Patel, Jeremiah Woodcock, Ryan Beams, Stephan J. Stranick, Ryan Nieuwendaal, Jeffrey W. Gilman, Marina R. Mulenos, Christie M. Sayes, Maryam Salari, Glen DeLoid, Philip Demokritou, Bryan Harper, Stacey Harper, Kimberly J. Ong, Jo Anne Shatkin, Douglas M. Fox
Summary: An optimal methodology for locating and tracking cellulose nanofibers (CNFs) is crucial to evaluate the environmental health and safety properties of these nanomaterials. A new boron-dipyrromethene (BODIPY) reactive fluorescent probe, meso-DichlorotriazineEthyl BODIPY (mDTEB), was used to label CNFs for ingestion exposure studies. The photoluminescence properties of mDTEB-labeled CNFs include excellent stability and high quantum yield. In vitro and in vivo studies showed that CNFs and mDTEB-labeled CNFs did not exhibit cytotoxicity.
Article
Green & Sustainable Science & Technology
Anu Kumar Das, Dayal Ch Shill, Saibal Chatterjee
Summary: This paper examines the application of natural esters and new vegetable oils as alternatives to conventional mineral oils in the electric utility. It focuses on the dielectric performance and environmental safety of coconut oil, and discusses its sustainability and market potential.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Environmental Sciences
Shu-Zhen Deng, Xin-Yang Li, Zi-Ming Wang, Jun-Bo Wang, Dan-Yang Han, Jia-Hao Fan, Qi Zhao, Huan Liu, Xin-Shuai Wang
Summary: DMP exhibits greater attractiveness to sexually mature males of the Oriental fruit fly than E-CF in laboratory bioassays, with varying responsiveness throughout the day. Toxicological experiments demonstrate that DMP is non-toxic, showing promise as an effective lure for controlling B. dorsalis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Infectious Diseases
Melanie Koinari, Nakei Bubun, Brogan Amos, Kiari Kiari, David Lahu, Stephan Karl
Summary: This study compared the bioassay board configuration and mosquito species used in WHO cone bioassays and found that these factors systematically affect the outcomes, highlighting the need for further harmonization of the methodology. The results varied not only with bioassay board configuration but also with mosquito colony, which impedes generalizability of WHO cone bioassay outcomes.
Review
Agronomy
Mousumi Mondal, Benukar Biswas, Sourav Garai, Sukamal Sarkar, Hirak Banerjee, Koushik Brahmachari, Prasanta Kumar Bandyopadhyay, Sagar Maitra, Marian Brestic, Milan Skalicky, Peter Ondrisik, Akbar Hossain
Summary: Zeolites, as natural minerals, can improve soil properties, alleviate heavy metal toxicity, and reduce nutrient leaching when used as soil ameliorants. They also have selectivity for major essential nutrients, facilitating optimal nutrient release during crop growth and improving fertilizer and water use efficiency.
Article
Entomology
G. Preetha, J. Stanley, S. Suresh
Summary: Understanding the impact of insecticides on natural enemies in the rice ecosystem is essential for successful pest management. This study evaluated the contact toxicity of commonly used insecticides in rice on the wolf spider and compared it with their toxicity to the rice leaf folder. The results showed that most insecticides negatively affected spiders, but a few insecticides had low contact toxicity.
INTERNATIONAL JOURNAL OF PEST MANAGEMENT
(2023)
Article
Environmental Sciences
Ebenezer Ashun, Seunggyu Kim, Min Jang, Kyu-Jung Chae, Sang-Eun Oh
Summary: A direct contact bioassay of thiosulfate employing denitrifying bacteria (TUDB) was used to assess the toxicity of naturally contaminated field soils and soils artificially contaminated with heavy metals. The TUDB assay proved to be highly sensitive and robust, and all eight contaminated soils were found to be toxic.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Food Science & Technology
Joana Moura, Cintia Ferreira-Pego, Ana Sofia Fernandes
Summary: This study investigated the preferences, safety perceptions, and usage practices of Portuguese consumers regarding Food Contact Materials (FCM) used for cooking and food storage. Results showed that safety was the most important factor when choosing cookware materials, although the criteria varied with age. Most respondents recognized the risk of food contamination through cookware. Stainless steel and glass were considered the safest materials for cooking, and glass and plastic were the most commonly used for food storage. Older individuals had better maintenance practices and knowledge about handling cookware. There was a general lack of knowledge about FCM symbols. This study highlights the need to provide reliable information to the public regarding cookware, promoting health literacy and reducing exposure to food contact chemicals.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Oncology
Alexandre Crosnier, Chadi Abbara, Morgane Cellier, Laurence Lagarce, Marina Babin, Delphine Bourneau-Martin, Marie Briet
Summary: This study found that the renal toxicity of anti-EGFR drugs is primarily related to renal failure in the context of digestive toxicity. Signals of disproportionate reporting were observed for afatinib and erlotinib with acute kidney injury, and for afatinib, cetuximab, and erlotinib with renal failure. Additionally, erlotinib was associated with haemolytic and uremic syndrome and thrombotic microangiopathy.
Article
Polymer Science
Nuttapol Tanadchangsaeng, Anchana Pattanasupong
Summary: Thousands of tons of non-biodegradable plastic waste are dumped into Thailand's marine environments every year, causing harm to marine animals. This study focuses on assessing the environmental safety and biodegradability of polyhydroxybutyrate (PHB) and PHA copolymer (PHBVV) in Thailand's seawater. The results show that both PHB and PHBVV can be effectively biodegraded, with biodegradation rates of 61.2% and 96.5% respectively. The study also found no residual toxicity in the marine environment, indicating that these materials are safe for the ecosystem.
Review
Nanoscience & Nanotechnology
Debolina Chakraborty, Debayan Ghosh, Sanjit Kumar, David Jenkins, Natarajan Chandrasekaran, Amitava Mukherjee
Summary: Oral cancer is a global problem, mainly caused by tobacco, alcohol, and poor dental hygiene. Conventional diagnostic and therapeutic approaches have limitations, and there is a need to enhance analytical performance. Nanoprobes have shown promise for early screening and predicting treatment outcomes for oral cancer.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Pazhamthavalathil Anil Athulya, Natarajan Chandrasekaran
Summary: The demand for plastics is expected to rise due to the exponential growth of the manufacturing sector. The plastic industries receive subsidies to boost foreign exchange. Mismanagement of plastic waste has caused contamination of water bodies with macro, micro, and nano plastics, leading to toxicological impairment in aquatic and terrestrial environments. The study investigates the interaction of polystyrene and polyethylene microplastics with natural colloids in waters, observing the formation of an eco-corona layer and its impact on detection methods.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Shramana Koner, Ida Florance, Amitava Mukherjee, Natarajan Chandrasekaran
Summary: This study investigates the toxic effects of polystyrene nanoparticles (PSNPs) on human macrophages. The results show that exposure to PSNPs leads to cytotoxicity, oxidative stress, decreased cell proliferation, decreased mitochondrial membrane potential, and DNA damage in human macrophages.
Article
Fisheries
Haimanti Mondal, Natarajan Chandrasekaran, Amitava Mukherjee, John Thomas
Summary: Marine actinomycetes are under-explored but have the potential to be a source of novel bacterial species. In this study, 16 bacterial strains were isolated using Actinomycetes Isolation Agar medium, and two of them showed antibacterial activity against shrimp pathogens. One of the strains, Bacillus licheniformis VIT02, exhibited potent antibacterial properties. The bioactive compounds extracted from B. licheniformis were found to have antimicrobial properties and showed promise as antimicrobial drugs. The study also demonstrated the effectiveness of the bioactive compounds in treating A. hydrophila infection in M. rosenbergii.
AQUACULTURE INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Soupam Das, N. Chandrasekaran, Amitava Mukherjee
Summary: During the COVID-19 pandemic, improper disposal of face masks has led to them becoming a significant source of microplastics and nano plastics in the environment. This study quantified and characterized the microplastics released from different layers of masks and investigated their effects on two algal species. The results showed negative impacts on cell viability, photosynthetic yield, and electron transport rate, as well as increased oxidative stress markers and antioxidant enzyme levels. Optical microscopy and FTIR spectroscopy confirmed morphological and chemical changes in the algae. The study highlights the environmental risks posed by microplastics released from surgical face masks and emphasizes the need for further research on their impacts.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Cell Biology
Haimanti Mondal, D. Delsy Gnana Silvia, I. Arnold Emerson, Natarajan Chandrasekaran, Amitava Mukherjee, John Thomas
Summary: Seven novel compounds were extracted from the ethyl acetate extract of a novel marine bacterium Bacillus licheniformis, which were identified using GC-MS. One bioactive compound with potent antibacterial activity was virtually screened and found to satisfy Lipinski's rule, making it suitable for preventing infection by A. hydrophila and V. parahemolyticus. Molecular docking and dynamics simulations showed strong binding efficacy of the bioactive compound against the core proteins of the two pathogens. In vitro toxicity analysis revealed the non-toxic nature of the ethyl acetate extract. Thus, the bioactive compound of B. licheniformis was proven to be a potent antibacterial agent against A. hydrophila and V. parahemolyticus.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Plant Sciences
Sayani Giri, Abisha Christy Christudoss, Natarajan Chandrasekaran, Willie J. G. M. Peijnenburg, Amitava Mukherjee
Summary: Both BPA and PSNPs are commonly found in consumer products and pose serious threats to the environment and aquatic life. This study examined the toxic effects of PS-NPs and BPA on the microalgae Scenedesmus obliquus, as well as the impact of algal EPS on their interaction. The results showed that EPS-containing mixtures reduced toxicity by decreasing reactive oxygen species levels, antioxidant enzyme activity, and cell membrane damage, leading to improved photosynthetic pigment content in the cells.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Namrata Roy, Krishnan Kannabiran, Amitava Mukherjee
Summary: Ferrocene functionalized rGO-ZnO nanocomposite was synthesized via hydrothermal method and showed superior photocatalytic activity in the degradation of pharmaceuticals under UV C light. The integration of Fc@rGO and ZnO enhanced light harvesting, charge carrier interface, and charge separation, leading to a fivefold increase in removal efficiency compared to pristine ZnO. The nanocomposite also exhibited low toxicity and reusability for multiple cycles, making it environmentally sustainable and suitable for practical applications in antibiotic treatment.
Article
Chemistry, Multidisciplinary
Kavita B. B. Hiremath, Murugesh Shivashankar, Natarajan Chandrasekaran
Summary: A series of new Tris hydroxymethyl aminomethane Schiff base derivatives were synthesized and characterized using various spectroscopic techniques. The binding interaction of these synthesized molecules with human serum albumin (HSA) was studied under pH=7.40 conditions. The results showed that the ligands had a high affinity for HSA and induced conformational changes in HSA. The antimicrobial activity of the synthesized compounds was also tested against Escherichia coli, Stap. aureus, Aspergillus niger, and Aspergillus flavus.
Article
Multidisciplinary Sciences
A. N. K. V. Sravani, Natarajan Chandrasekaran, John Thomas, Amitava Mukherjee
Summary: This study developed a new cisplatin loaded hydroxyl functionalized single-walled carbon nanotube nanocarrier system to selectively eliminate gastric cancer stem cells, overcoming the resistance caused by non-specific and non-targeted drug delivery by chemotherapy.
Article
Biochemistry & Molecular Biology
Parvathy Mohan Menon, Natarajan Chandrasekaran, C. George Priya Doss, Sivakumar Shanmugam
Summary: The aim of this research is to optimize and formulate a multi-drug loaded eugenol based nanoemulsion system for the treatment of tuberculosis caused by Mycobacterium tuberculosis. The study showed that the essential oil-based nanoemulsions exhibited promising results as antimycobacterial agents, especially when combined with a combination of drugs. The release kinetics studies also demonstrated a controlled and sustained release of the first-line anti-tubercular drugs. These findings highlight the potential of this nanoemulsion system as an efficient and desirable method in treating infections caused by Mycobacterium tuberculosis and its drug-resistant strains.
RSC MEDICINAL CHEMISTRY
(2023)
Review
Microbiology
Simpal Kumar Suman, Natarajan Chandrasekaran, C. George Priya Doss
Summary: Tuberculosis is a global health problem and drug resistance has made it increasingly difficult to treat. Researchers are exploring new drugs and drug delivery systems, such as nanotechnology, to combat drug resistance. However, the clinical translation of nanomedicines faces challenges such as safety, production, regulation, and intellectual property.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Article
Chemistry, Analytical
Pazhamthavalathil Anil Athulya, Natarajan Chandrasekaran, John Thomas
Summary: Gut probiotic bacteria play a significant role in the host health, immunity, and survival. Changes in the gut microbiome of fishes due to microplastic exposure could lead to alterations in bacterial growth and viability, exopolysaccharide production, and oxidative stress response. The study provides new insights into the interaction between microplastics and gut probiotics in aquaculture species.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Environmental Sciences
Pazhamthavalathil Anil Athulya, Zachariah Sunil, Sonia Manzo, Natarajan Chandrasekaran
Summary: This study examines the effects of microplastics and low pH on the physiology and development of Artemia salina through exposure experiments. The results indicate that the combined exposure to microplastics and low pH induces oxidative stress and adversely affects the development of Artemia salina. These findings underscore the need for further research on the combined toxicological impacts of ocean acidification and predominant pollutants like microplastics on other marine animals.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Chemistry, Analytical
Abisha Christy Christudoss, Natarajan Chandrasekaran, Amitava Mukherjee
Summary: Due to the escalating risk of plastic pollution, nanoplastics have received significant attention. A study examined the individual and combined effects of fluorescent polystyrene nanoplastics (FNPs) and diclofenac (DCF) on Scenedesmus obliquus. The toxicity of S. obliquus significantly increased upon exposure to DCF and FNPs, with oxidative stress being the major cause. When FNPs and DCF were mixed, a synergistic or antagonistic effect was observed depending on the concentrations. Oxidative stress parameters, antioxidant enzyme activity, and pigment content in the algae validated the cytotoxicity data. The study highlights the hazardous nature of nanoplastics and their co-exposure risks with pharmaceuticals.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
