Article
Biochemistry & Molecular Biology
Theresa Strauss, Burkhard Greve, Michael Gabriel, Nurjannah Achmad, Dhanusha Schwan, Nancy Adriana Espinoza-Sanchez, Antonio Simone Lagana, Ludwig Kiesel, Matti Poutanen, Martin Goette, Sebastian Daniel Schaefer
Summary: This study found that the silencing of Musashi-1 and Musashi-2 increased cell apoptosis and necrosis, and reduced the expression of stem cell genes and cell proliferation in endometriosis. Additionally, the Musashi genes had an impact on the expression of the cell cycle regulator p21. These findings suggest the therapeutic potential of targeting the Musashi-Notch axis in the treatment of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Miguel Padial-Molina, Vicente Crespo-Lora, Clara Candido-Corral, Nati Martin-Morales, Dario Abril-Garcia, Pablo Galindo-Moreno, Pedro Hernandez-Cortes, Francisco O'Valle
Summary: The study revealed that MSI1 and RUNX2 expression increased over time during bone healing, while the expression of POSTN decreased. MSI1 was found to be expressed in mesenchymal stromal cells, osteoblasts, and osteocytes, suggesting a potential role in bone healing and osteogenic differentiation. The significant correlation between MSI1, POSTN, and RUNX2 after 14 days indicates the need for further research on MSI1 as a clinical biomarker for bone healing and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Andrea Reszegi, Peter Tatrai, Eszter Regos, Ilona Kovalszky, Kornelia Baghy
Summary: Syndecan-1 is a protein that regulates cell activities and plays a crucial role in liver diseases and hepatocellular carcinoma. It is involved in various physiological and pathological processes, including cell proliferation, inflammation, and matrix remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria T. Loeblein, Isabel Falke, Hans Theodor Eich, Burkhard Greve, Martin Goette, Fabian M. Troschel
Summary: Translation:
In ovarian cancer, targeting Musashi RNA-binding proteins (MSI) may increase therapeutic efficacy by affecting CSC and cell cycle gene expression, metabolic activity, and chemo- and radioresistance. Database analyses revealed associations between MSI proteins and key genes, supporting the potential of MSI dual knockdown to impede tumor growth and sensitize cancer cells to therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Zoi Piperigkou, Anastasios Koutsandreas, Marco Franchi, Vasiliki Zolota, Dimitrios Kletsas, Alberto Passi, Nikos K. Karamanos
Summary: Estrogen receptors (ERs) play a pivotal role in the development and progression of triple-negative breast cancer (TNBC). This study investigates the exact role of ER beta in the progression of TNBC. The findings suggest that targeting ER beta may be a promising approach for managing the metastatic dynamics of TNBC breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jian Sun, Weiwei Sheng, Yuteng Ma, Ming Dong
Summary: In the aggressive progression of malignant tumors, MSI2 plays a crucial role in regulating EMT and is closely associated with the EGF, TGF-beta, Notch, and Wnt pathways.
ONCOTARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Mona Sheta, Martin Goette
Summary: This review summarizes the current understanding of breast carcinogenesis in correlation with Syndecan-1 expression, the mechanisms involved, and proposed therapeutic strategies against Syndecan-1-related malignancy.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Tiffany S. Haiduk, Mark Sicking, Kathrin A. Bruecksken, Nancy A. Espinoza-Sanchez, Kai Moritz Eder, Bjoern Kemper, Hans Theodor Eich, Martin Goette, Burkhard Greve, Fabian M. Troschel
Summary: This study reveals the crucial role of Musashi RNA-binding proteins in inflammatory breast cancer, as they are associated with tumor proliferation, cancer stem cell characteristics, and therapy resistance. Inhibiting the expression of MSI genes can alleviate drug resistance and tumor growth.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Review
Biology
Nadine Bley, Ali Hmedat, Simon Mueller, Robin Rolnik, Alexander Rausch, Marcell Lederer, Stefan Huettelmaier
Summary: The RNA-binding protein Musashi-1 (MSI1) plays a crucial role in promoting stemness properties during development and in cancer, contributing to cancer growth and therapy resistance. MSI1's specific expression pattern and diverse functions make it an interesting target for future cancer therapy, with current research focusing on MSI1-directed inhibitors with anti-tumor activity.
Article
Cell Biology
Ting Li, Zhonghua Tao, Yihui Zhu, Xiaojia Liu, Leiping Wang, Yiqun Du, Jun Cao, Biyun Wang, Jian Zhang, Xichun Hu
Summary: Exosomes derived from resistant cancer cells induce gemcitabine resistance in triple-negative breast cancer cells through upregulating ANXA6 expression, which is associated with the inhibition of EGFR ubiquitination and degradation. Exosomal ANXA6 levels in the serum of patients with TNBC may serve as a predictive factor for response to gemcitabine-based chemotherapy.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Arushi Jaiswal, Kiichi Murakami, Andrew Elia, Yukiko Shibahara, Susan J. Done, Stephen A. Wood, Nicholas J. Donato, Pamela S. Ohashi, Michael Reedijk
Summary: The study suggests that inhibition of USP9x can treat TNBC by reducing Notch activity, decreasing tumor inflammation, enhancing antitumor immune response, and suppressing tumor growth. Pharmacological inhibition of USP9x can remodel the tumor immune landscape, reduce tumor growth without toxicity, and target Notch in metabolically vulnerable tissues like TNBC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Zecheng Yang, Shuaitong Chen, Haoqiang Ying, Wantong Yao
Summary: This review summarizes the current knowledge on the structure and functions of Syndecan-1 (SDC1) and its role in tumor biology. The review highlights the critical role of SDC1 in promoting tumorigenesis and metastasis, and emphasizes the potential of utilizing SDC1 as a novel target for cancer therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Oncology
Petr Makhov, Igor Bychkov, Bulat Faezov, Alexander Deneka, Alexander Kudinov, Emmanuelle Nicolas, Rohan Brebion, Eleanor Avril, Kathy Q. Cai, Leonid V. Kharin, Mark Voloshin, Elena Frantsiyants, Nikolay Karnaukhov, Oleg I. Kit, Iuliia Topchu, Rushaniya Fazliyeva, Anna S. Nikonova, Ilya G. Serebriiskii, Hossein Borghaei, Martin Edelman, Essel Dulaimi, Erica A. Golemis, Yanis Boumber
Summary: MSI2 regulates EGFR protein expression in non-small cell lung cancer, and depletion of MSI2 can affect proliferation of EGFR(mut) cells and response to EGFR-targeting drugs, suggesting inhibition of MSI2 could be clinically valuable in EGFR(mut) NSCLC.
Article
Critical Care Medicine
Julie Goswami, Taleen MacArthur, Kent Bailey, Grant Spears, Rosemary A. Kozar, Matthew Auton, Jing-Fei Dong, Nigel S. Key, Stephanie Heller, Erica Loomis, Nathan W. Hall, Andrea L. Johnstone, Myung S. Park
Summary: This pilot study found that trauma patients exhibit increased NETosis, elevated syndecan-1 shedding, and accelerated thrombin generation kinetics early after injury. Levels of H3NUC and H3Free were significantly higher in trauma patients and showed positive correlations with syndecan-1 levels.
Article
Biochemistry & Molecular Biology
Sampath Kumar Katakam, Valeria Tria, Wey-Cheng Sim, George W. Yip, Stefano Molgora, Theodoros Karnavas, Eslam A. Elghonaimy, Paride Pelucchi, Eleonora Piscitelli, Sherif Abdelaziz Ibrahim, Ileana Zucchi, Rolland Reinbold, Burkhard Greve, Martin Goette
Summary: The downregulation of Sdc-1 in colon cancer is associated with increased invasiveness, metastasis, and potential tumor-initiating cell phenotype. Sdc-1 depletion enhances cancer stem cell properties and resistance to chemotherapy, while also promoting invasive growth of cancer cells.
Review
Oncology
Efthymia Papakonstantinou, Zoi Piperigkou, Nikos K. Karamanos, Vasiliki Zolota
Summary: Obesity is closely associated with the overall risk of breast cancer, particularly in the development of triple negative breast cancer. The molecular mechanisms behind this association have not been fully understood. Obesity affects the tumor microenvironment through metabolic modifications, leading to the secretion of inflammatory factors, chemokines, and adipokines that promote the induction, evolution, and metastasis of breast cancer and hinder anti-cancer drug response. This article focuses on the expression of adipokines and their association with breast cancer, specifically triple negative subtype, and provides a summary of novel research findings. The aim is to improve strategies for tumor stratification and management.
Editorial Material
Oncology
Nikos K. Karamanos, Martin Goette, Alberto Passi
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Denisa Druvari, Ioanna Tzoumani, Zoi Piperigkou, Kyriaki Tzaferi, Dimitris Tselentis, Alexios Vlamis-Gardikas, Nikos K. Karamanos, Georgios Bokias, Joannis K. Kallitsis
Summary: Air pollution caused by pathogens has gained significant attention in recent years due to its impact on global health. In this study, researchers have developed a spray coating method to produce antibacterial air filters, effectively addressing the challenge of preventing secondary pollution in air-filtering devices. These filters exhibit strong and rapid antibacterial activity, making them promising candidates for filter coatings in air-purification devices.
Review
Biochemistry & Molecular Biology
Konstantina Kyriakopoulou, Zoi Piperigkou, Kyriaki Tzaferi, Nikos K. Karamanos
Summary: Extracellular matrix plays a crucial role in regulating cell behavior and disease progression. Recent advances in big data analytics have opened up new possibilities for studying the complex interactions of extracellular matrix, which could potentially lead to more targeted therapies.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Konstantina Kyriakopoulou, Christos Koutsakis, Zoi Piperigkou, Nikos K. Karamanos
Summary: Cancer initiation and progression depend on microenvironmental cues, particularly the extracellular matrix (ECM). Two-dimensional (2D) cell culture systems cannot accurately replicate the in vivo matrix microenvironmental architecture. Therefore, researchers have focused on developing advanced three-dimensional (3D) culture models to mimic specific tumor and tissue environments. These 3D culture systems provide improved tools for studying cancer progression and exploring innovative therapies.
Article
Biochemistry & Molecular Biology
Zoi Piperigkou, Dimitra Bainantzou, Nadia Makri, Eleni Papachristou, Aglaia Mantsou, Theodora Choli-Papadopoulou, Achilleas D. D. Theocharis, Nikos K. K. Karamanos
Summary: This study investigates the role of type II collagen in promoting chondrogenic differentiation in mesenchymal stem cells (MSCs). The results show that type II collagen enhances chondrogenesis in both Wharton's jelly and dental pulp-derived MSCs.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Eleni Zygouri, Vlasoula Bekiari, Georgios Malis, Nikos K. Karamanos, Christos Koutsakis, George Psomas, Vassilis Tangoulis
Summary: This study presents a simple experimental protocol for synthesizing poly(ethylene glycol)-modified gold nanorods (AuNRs@PEG) and an effective drug loading procedure using naproxen (NAP), a non-steroidal anti-inflammatory drug (NSAID). The interaction of AuNRs@PEG and drug-loaded AuNRs (AuNRs@PEG@NAP) with calf-thymus DNA was studied, revealing different interaction modes. The pH-sensitive drug release behavior and cytotoxicity against breast cancer cell lines were also evaluated.
Review
Oncology
Nicholas S. Mastronikolis, Efthymios Kyrodimos, Despoina Spyropoulou, Alexander Delides, Evangelos Giotakis, Zoi Piperigkou, Nikos K. Karamanos
Summary: Exosomes are nanosized vesicles produced by cells that play important roles in head and neck cancer development and metastasis by altering signaling pathways in recipient cells through the cargoes they carry. This article focuses on exosome biogenesis, their cargoes, and their involvement in epithelial-to-mesenchymal transition (EMT) induction and metastasis in head and neck cancer. It also discusses the key role of exosomes in extracellular matrix remodeling and degradation, and their potential as diagnostic and therapeutic tools.
Editorial Material
Biochemistry & Molecular Biology
Marco Franchi, Zoi Piperigkou, Nicholas S. Mastronikolis, Nikos Karamanos
Summary: Extracellular matrices (ECMs) are dynamic 3D macromolecular networks that play important roles in various biological processes, including organ development, tissue homeostasis, and disease progression. The interactions between ECM macromolecules, matrix effectors, and water contribute to cellular and tissue functional properties. Altered ECM composition can lead to abnormal cell behavior and tissue dysfunction. Understanding the biomechanical functionality and adaptation mechanisms of ECMs is crucial for studying pathologies and developing targeted therapies, especially in cancer progression and multidrug resistance.