Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection

Multiple domain interfaces mediate SARM1 autoinhibition

(2021) Chen Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

(2021) Robert O. Hughes et al.   Cell Reports

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

(2021) Matthew D. Figley et al.   NEURON

Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy

(2021) Todd Bosanac et al.   BRAIN

Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration

(2020) Raul Krauss et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease

(2020) Matthew D Figley et al.   CURRENT OPINION IN NEUROBIOLOGY

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration

(2020) Kwang Woo Ko et al.   JOURNAL OF CELL BIOLOGY

SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration

(2020) Ema Ozaki et al.   Life Science Alliance

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1

(2020) Yuefeng Jiang et al.   NATURE

Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation

(2020) Aysel Cetinkaya-Fisgin et al.   Scientific Reports

Structural Evidence for an Octameric Ring Arrangement of SARM1

(2019) Michael Sporny et al.   JOURNAL OF MOLECULAR BIOLOGY

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

Sarm1 deletion reduces axon damage, demyelination, and white matter atrophy after experimental traumatic brain injury

(2019) Christina M. Marion et al.   EXPERIMENTAL NEUROLOGY

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

(2019) Audrey Sambeat et al.   Nature Communications

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

MX2: a high-flux undulator microfocus beamline serving both the chemical and macromolecular crystallography communities at the Australian Synchrotron

(2018) David Aragão et al.   JOURNAL OF SYNCHROTRON RADIATION

Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration

(2018) Hui-wen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

(2017) Elliot Turkiew et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice

(2016) Stefanie Geisler et al.   BRAIN

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lackingSarm1

(2016) Nils Henninger et al.   BRAIN

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

(2016) Joanna Ratajczak et al.   Nature Communications

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

(2016) Yo Sasaki et al.   eLife

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes

(2014) Keisuke Hikosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Dysfunction Induces Sarm1-Dependent Cell Death in Sensory Neurons

(2014) D. W. Summers et al.   JOURNAL OF NEUROSCIENCE

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Axonal Degeneration Is Blocked by Nicotinamide Mononucleotide Adenylyltransferase (Nmnat) Protein Transduction into Transected Axons

(2010) Yo Sasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals

(2008) Peter Belenky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY