The Egr-1/miR-15a-5p/GPX4 axis regulates ferroptosis in acute myocardial infarction

Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis

(2020) Naoya Yamada et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice

(2020) Yufang Song et al.   CELL BIOLOGY AND TOXICOLOGY

Ferroptosis occurs in phase of reperfusion but not ischemia in rat heart following ischemia or ischemia/reperfusion

(2020) Li-Jing Tang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF-A promotes angiogenesis after acute myocardial infarction through increasing ROS production and enhancing ER stress-mediated autophagy

(2019) Jiang Zou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24

(2019) Fei Han et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

(2019) Xiaoqing Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury

(2019) Lianjiu Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

(2019) Tae-Jun Park et al.   Cell Death & Disease

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

(2018) Bei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7

(2018) Linshan Yang et al.   Cell Death & Disease

N-n-Butyl Haloperidol Iodide, a Derivative of the Anti-psychotic Haloperidol, Antagonizes Hypoxia/Reoxygenation Injury by Inhibiting an Egr-1/ROS Positive Feedback Loop in H9c2 Cells

(2018) Ting Sun et al.   Frontiers in Pharmacology

Remote ischemic preconditioning attenuates EGR-1 expression following myocardial ischemia reperfusion injury through activation of the JAK-STAT pathway

(2017) H Mudaliar et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Reduction in mitochondrial iron alleviates cardiac damage during injury

(2016) H.-C. Chang et al.   EMBO Molecular Medicine

Early growth response-1 in the pathogenesis of cardiovascular disease

(2016) Levon M. Khachigian   JOURNAL OF MOLECULAR MEDICINE-JMM

MicroRNA-34a Plays a Key Role in Cardiac Repair and Regeneration Following Myocardial InfarctionNovelty and Significance

(2015) Yanfei Yang et al.   CIRCULATION RESEARCH

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation

(2015) Yanmei Zhang et al.   Scientific Reports

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

MicroRNA-150 Protects the Heart From Injury by Inhibiting Monocyte Accumulation in a Mouse Model of Acute Myocardial InfarctionCLINICAL PERSPECTIVE

(2014) Zheng Liu et al.   Circulation-Cardiovascular Genetics

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Selective Inhibition of the Master Regulator Transcription Factor Egr‐1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction

(2013) Benjamin S. Rayner et al.   Journal of the American Heart Association

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

(2012) E. R. Porrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury

(2012) Liu Li-Feng et al.   Journal of Geriatric Cardiology

Inhibition of miR-15 Protects Against Cardiac Ischemic Injury

(2011) Thomas G. Hullinger et al.   CIRCULATION RESEARCH

miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes

(2011) Li Qian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pervasive roles of microRNAs in cardiovascular biology

(2011) Eric M. Small et al.   NATURE

MicroRNAs Add a New Dimension to Cardiovascular Disease

(2010) Eric M. Small et al.   CIRCULATION

microRNAs in heart disease: putative novel therapeutic targets?

(2010) G. Condorelli et al.   EUROPEAN HEART JOURNAL

The Protective Effect of Egr-1 Antisense Oligodeoxyribonucleotide on Myocardial Injury Induced by Ischemia-reperfusion and Hypoxia-reoxygenation

(2008) Yanmei Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION