Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor

Effect of spexin on renal dysfunction in experimentally obese rats: potential mitigating mechanisms via galanin receptor-2

(2021) Mervat H. El-Saka et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-ɣ and AMPK and inhibiting IL-6 and TNF-α

(2021) Mona A. Said et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus

(2021) Matthew K. H. Wong et al.   Frontiers in Endocrinology

30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and metabolic status

(2021) Pawel A. Kolodziejski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes

(2020) Abdelkrim Khadir et al.   Scientific Reports

Short-term administration of spexin in rats reduces obesity by affecting lipolysis and lipogenesis: An in vivo and in vitro study

(2020) Ewa Pruszynska-Oszmalek et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Palmitate differentially regulates Spexin, and its receptors Galr2 and Galr3, in GnRH neurons through mechanisms involving PKC, MAPKs, and TLR4

(2020) Lu Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight

(2019) Seongsik Yun et al.   Frontiers in Neuroscience

Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with Prediabetes

(2019) Nasser M. Al-Daghri et al.   Scientific Reports

Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction

(2019) Yang Liu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Galanin peptide family regulation of glucose metabolism

(2019) Penghua Fang et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons

(2019) Andy Tran et al.   NEUROSCIENCE

Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents

(2019) Flora Bacopoulou et al.   Journal of Clinical Medicine

Skeletal Muscle–Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance

(2018) Ahmed Lawan et al.   DIABETES

Spexin Modulates Functions of Rat Endocrine Pancreatic Cells

(2018) Maciej Sassek et al.   PANCREAS

Roux en-Y gastric bypass surgery in youth with severe obesity: 1-year longitudinal changes in spexin

(2018) Seema Kumar et al.   Surgery for Obesity and Related Diseases

Spexin: A novel regulator of adipogenesis and fat tissue metabolism

(2018) Pawel A. Kolodziejski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Spexin Levels Are Associated with Metabolic Syndrome Components

(2018) Nasser M. Al-Daghri et al.   DISEASE MARKERS

Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes

(2018) Anara Karaca et al.   MEDICAL PRINCIPLES AND PRACTICE

Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout Study

(2017) Binbin Zheng et al.   Scientific Reports

Prmt7 Deficiency Causes Reduced Skeletal Muscle Oxidative Metabolism and Age-Related Obesity

(2016) Hyeon-Ju Jeong et al.   DIABETES

Decreased Circulating Levels of Spexin in Obese Children

(2016) Seema Kumar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of Hepatocellular Fatty Acid Uptake in Mouse Models of Fatty Liver Disease with and without Functional Leptin Signaling: Roles of NfKB and SREBP-1C and the Effects of Spexin

(2016) Jasmine Ge et al.   SEMINARS IN LIVER DISEASE

Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice

(2016) Arfaxad Reyes-Alcaraz et al.   Scientific Reports

Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes

(2015) Liping Gu et al.   PEPTIDES

Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III

(2014) Dong-Kyu Kim et al.   ENDOCRINOLOGY

Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity

(2014) José L. Walewski et al.   Obesity

Goldfish spexin: solution structure and novel function as a satiety factor in feeding control

(2013) Matthew K. H. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of glucose transport by insulin: traffic control of GLUT4

(2012) Dara Leto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats

(2010) C. R. Benton et al.   DIABETOLOGIA

Spexin Expression in Normal Rat Tissues

(2010) Andrea Porzionato et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Adipocyte Accumulation of Long-Chain Fatty Acids in Obesity is Multifactorial, Resulting from Increased Fatty Acid Uptake and Decreased Activity of Genes Involved in Fat Utilization

(2009) José L. Walewski et al.   OBESITY SURGERY

Evolutionary Sequence Modeling for Discovery of Peptide Hormones

(2009) Kemal Sonmez et al.   PLoS Computational Biology

Adipokines: The missing link between insulin resistance and obesity

(2008) B. Antuna-Puente et al.   DIABETES & METABOLISM