Towards quantification and differentiation of protein aggregates and silicone oil droplets in the low micrometer and submicrometer size range by using oil-immersion flow imaging microscopy and convolutional neural networks

Oil-Immersion Flow Imaging Microscopy for Quantification and Morphological Characterization of Submicron Particles in Biopharmaceuticals

(2021) Nils Krause et al.   AAPS Journal

Quantitative differentiation of protein aggregates from other subvisible particles in viscous mixtures through holographic characterization

(2020) Annemarie Winters et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Machine learning and statistical analyses for extracting and characterizing “fingerprints” of antibody aggregation at container interfaces from flow microscopy images

(2020) Austin L. Daniels et al.   BIOTECHNOLOGY AND BIOENGINEERING

Advanced Characterization of Silicone Oil Droplets in Protein Therapeutics Using Artificial Intelligence Analysis of Imaging Flow Cytometry Data

(2020) Christine Probst et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Applying pattern recognition as a robust approach for silicone oil droplet identification in flow-microscopy images of protein formulations

(2020) X. Gregory Chen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of Protein Aggregates, Silicone Oil Droplets, and Protein-Silicone Interactions using Imaging Flow Cytometry

(2019) Christine Probst   JOURNAL OF PHARMACEUTICAL SCIENCES

Automatic Identification of the Stress Sources of Protein Aggregates Using Flow Imaging Microscopy Images

(2019) Arni Gambe-Gilbuena et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Deep Convolutional Neural Network Analysis of Flow Imaging Microscopy Data to Classify Subvisible Particles in Protein Formulations

(2018) Christopher P. Calderon et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Holographic Characterization of Protein Aggregates in the Presence of Silicone Oil and Surfactants

(2018) Priya N.O. Kasimbeg et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Micro–Flow Imaging and Resonant Mass Measurement (Archimedes) – Complementary Methods to Quantitatively Differentiate Protein Particles and Silicone Oil Droplets

(2013) Daniel Weinbuch et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Development of Biotechnology Products in Pre-filled Syringes: Technical Considerations and Approaches

(2011) Advait Badkar et al.   AAPS PHARMSCITECH

Discrimination Between Silicone Oil Droplets and Protein Aggregates in Biopharmaceuticals: A Novel Multiparametric Image Filter for Sub-visible Particles in Microflow Imaging Analysis

(2011) René Strehl et al.   PHARMACEUTICAL RESEARCH