Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors

Design, synthesis, and Structure–Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors

(2020) Yunxin Duan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study

(2018) Theodore W Laetsch et al.   LANCET ONCOLOGY

Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

(2018) Alexander Drilon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor

(2016) Maria Menichincheri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications

(2016) E. Ardini et al.   MOLECULAR CANCER THERAPEUTICS

Structural characterization of nonactive site, TrkA-selective kinase inhibitors

(2016) Hua-Poo Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101

(2015) R. C. Doebele et al.   Cancer Discovery

Discovery of Pyrroloaminopyrazoles as Novel PAK Inhibitors

(2012) Chuangxing Guo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition

(2012) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors

(2012) Tao Wang et al.   ACS Medicinal Chemistry Letters

Brain-Derived Neurotrophic Factor (BDNF) has Proliferative Effects on Neural Stem Cells through the Truncated TRK-B Receptor, MAP Kinase, AKT, and STAT-3 Signaling Pathways

(2009) Omedul Islam et al.   CURRENT NEUROVASCULAR RESEARCH

Rearrangements of NTRK1 gene in papillary thyroid carcinoma

(2009) A. Greco et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases

(2008) Tao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY