Discovery of novel nitrogenous heterocyclic-containing quinoxaline-1,4-di-N-oxides as potent activator of autophagy in M.tb-infected macrophages

Discovery of 1,2,3-triazole based quinoxaline-1,4-di-N-oxide derivatives as potential anti-tubercular agents

(2020) Singireddi Srinivasarao et al.   BIOORGANIC CHEMISTRY

Primaquine–quinoxaline 1,4-di-N-oxide hybrids with action on the exo-erythrocytic forms of Plasmodium induce their effect by the production of reactive oxygen species

(2019) Leonardo Bonilla-Ramírez et al.   MALARIA JOURNAL

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase

(2019) Galina Karabanovich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Dioxides Derivatives

(2019) Liliana Silva et al.   Anti-Cancer Agents in Medicinal Chemistry

Quinoxaline and quinoxaline-1,4-di-N -oxides: An emerging class of antimycobacterials

(2018) Rangappa S. Keri et al.   ARCHIV DER PHARMAZIE

Global Epidemiology of Tuberculosis

(2018) Katherine Floyd et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Autophagy: A new strategy for host-directed therapy of tuberculosis

(2018) Seungwha Paik et al.   Virulence

Triazole derivatives and their anti-tubercular activity

(2017) Shu Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Autophagy as a regulator of cardiovascular redox homeostasis

(2017) Ye Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macrophage Autophagy and Bacterial Infections

(2017) Aïcha Bah et al.   Frontiers in Immunology

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

(2016) Nishad Thamban Chandrika et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis

(2016) Mery Santivañez-Veliz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

(2016) Dirk A. Lamprecht et al.   Nature Communications

Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions

(2016) Guyue Cheng et al.   Frontiers in Pharmacology

A Difluorobenzoxadiazole Building Block for Efficient Polymer Solar Cells

(2015) Jingbo Zhao et al.   ADVANCED MATERIALS

Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway

(2015) Yan Yang et al.   TUMOR BIOLOGY

Metformin as adjunct antituberculosis therapy

(2014) A. Singhal et al.   Science Translational Medicine

Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: Synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity

(2013) Mohamed Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Perturbing pro-survival proteins using quinoxaline derivatives: A structure–activity relationship study

(2012) Rajkumar Rajule et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Predicting the exposure and antibacterial activity of fluoroquinolones based on physicochemical properties

(2012) Gergely Völgyi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation

(2011) Tânia R. Mielcke et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Autophagy in immunity and cell-autonomous defense against intracellular microbes

(2011) Vojo Deretic   IMMUNOLOGICAL REVIEWS

The urgent need for new antibacterial agents

(2011) R. Wise et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The structure elucidation of mequindox and 1,4-bisdesoxymequindox: NMR analyses, FT-IR spectra, DFT calculations and thermochemical studies

(2011) Jiaheng Zhang et al.   JOURNAL OF MOLECULAR STRUCTURE

The Response of Mycobacterium Tuberculosis to Reactive Oxygen and Nitrogen Species

(2011) Martin I. Voskuil et al.   Frontiers in Microbiology

New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents

(2010) Saioa Ancizu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

(2010) Takahiro Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?

(2010) Samuel M. Behar et al.   NATURE REVIEWS MICROBIOLOGY

Global Burden and Epidemiology of Tuberculosis

(2009) Philippe Glaziou et al.   CLINICS IN CHEST MEDICINE

Evasion and subversion of antigen presentation byMycobacterium tuberculosis

(2009) A. Baena et al.   TISSUE ANTIGENS

Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis

(2008) E. Vicente et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selective activity against Mycobacterium tuberculosis of new quinoxaline 1,4-di-N-oxides

(2008) Esther Vicente et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide

(2008) R. Villar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Interactions of Antiviral Indolo[2,3-b]quinoxaline Derivatives with DNA

(2008) L. Marcus Wilhelmsson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY