Pathophysiology of T akotsubo syndrome – a joint scientific statement from the Heart Failure Association T akotsubo Syndrome Study Group and Myocardial Function Working Group of the E uropean Society of Cardiology – Part 1: overview and the central role for catecholamines and sympathetic nervous system

Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure

(2021) Liam S Couch et al.   CARDIOVASCULAR RESEARCH

Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

(2021) Elmir Omerovic et al.   EUROPEAN JOURNAL OF HEART FAILURE

The importance of heart rate in isoprenaline‐induced takotsubo‐like cardiac dysfunction in rats

(2020) Anwar Ali et al.   ESC Heart Failure

Takotsubo Syndrome and COVID-19: Associations and Implications

(2020) Rohan M. Shah et al.   CURRENT PROBLEMS IN CARDIOLOGY

Myocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy

(2019) Caroline Scally et al.   CIRCULATION

Takotsubo Recurrence

(2019) Ken Kato et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Long-term outcome in patients with Takotsubo syndrome presenting with severely reduced left ventricular ejection fraction

(2019) Rodolfo Citro et al.   EUROPEAN JOURNAL OF HEART FAILURE

Takotsubo syndrome in patients with cancer treated with immune checkpoint inhibitors: a new adverse cardiac complication

(2019) Stephane Ederhy et al.   EUROPEAN JOURNAL OF HEART FAILURE

Electrocardiographic predictors of adverse in-hospital outcomes in the Takotsubo syndrome

(2019) Sandeep Jha et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Prediction of short‐ and long‐term mortality in takotsubo syndrome: the InterTAK Prognostic Score

(2019) Manfred B. Wischnewsky et al.   EUROPEAN JOURNAL OF HEART FAILURE

Prognostic value of N-Terminal Pro-B-Type Natriuretic Peptide in Takotsubo syndrome

(2018) Thomas Stiermaier et al.   Clinical Research in Cardiology

Atrial arrhythmias in Takotsubo cardiomyopathy: incidence, predictive factors, and prognosis

(2018) Laurence Jesel et al.   EUROPACE

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

(2018) Jelena-Rima Ghadri et al.   EUROPEAN HEART JOURNAL

International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management

(2018) Jelena-Rima Ghadri et al.   EUROPEAN HEART JOURNAL

Ventricular arrhythmias and sudden cardiac arrest in Takotsubo cardiomyopathy: Incidence, predictive factors, and clinical implications

(2018) Laurence Jesel et al.   HEART RHYTHM

Toll-like receptor expression and apoptosis morphological patterns in female rat hearts with takotsubo syndrome induced by isoprenaline

(2018) Agnieszka Kołodzińska et al.   LIFE SCIENCES

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β 2 AR-cAMP Responsiveness in Murine Hearts

(2018) Peter T. Wright et al.   Cell Reports

The bidirectional interaction between the sympathetic nervous system and immune mechanisms in the pathogenesis of hypertension

(2018) Revathy Carnagarin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study

(2018) Tomoya Nakano et al.   Scientific Reports

Effects of pretreatment with cardiostimulants and beta-blockers on isoprenaline-induced takotsubo-like cardiac dysfunction in rats

(2018) Anwar Ali et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardiac Disorders and Pathophysiology of Sarcomeric Proteins

(2018) Jolanda van der Velden et al.   PHYSIOLOGICAL REVIEWS

Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction

(2018) Roland Veltkamp et al.   Journal of Cachexia Sarcopenia and Muscle

The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

(2017) Marc van Bilsen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Glycocalyx shedding is markedly increased during the acute phase of Takotsubo cardiomyopathy

(2017) Thanh H. Nguyen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Prevalence and prognostic relevance of atrial fibrillation in patients with Takotsubo syndrome

(2017) Thomas Stiermaier et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Takotsubo cardiomyopathy associated with epinephrine use: A systematic review and meta-analysis

(2017) Salik Nazir et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Drug-Induced Takotsubo Cardiomyopathy

(2017) Kazuhiko Kido et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy

(2017) Thomas Borchert et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway

(2017) Lorenz H Lehmann et al.   NATURE MEDICINE

Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

(2017) Vicente J. Planelles-Herrero et al.   Nature Communications

Persistent Long-Term Structural, Functional, and Metabolic Changes After Stress-Induced (Takotsubo) Cardiomyopathy

(2017) Caroline Scally et al.   CIRCULATION

Long QT syndrome and life-threatening anaphylaxis

(2016) Jennifer L. White et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

(2016) Jennifer Davis et al.   CELL

Happy heart syndrome: role of positive emotional stress in takotsubo syndrome

(2016) Jelena R. Ghadri et al.   EUROPEAN HEART JOURNAL

Management of arrhythmias in patients with Takotsubo cardiomyopathy: Is the implantation of permanent devices necessary?

(2016) Thomas Stiermaier et al.   HEART RHYTHM

Coronary microvascular dysfunction is associated with baseline QTc prolongation amongst patients with chest pain and non-obstructive coronary artery disease

(2016) Jaskanwal D. Sara et al.   JOURNAL OF ELECTROCARDIOLOGY

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

Natural History of Cardiac Arrest in Patients With Takotsubo Cardiomyopathy

(2015) Kuljit Singh et al.   AMERICAN JOURNAL OF CARDIOLOGY

Targets for therapy in sarcomeric cardiomyopathies

(2015) J. C. Tardiff et al.   CARDIOVASCULAR RESEARCH

Clinical Impact of Left Ventricular Outflow Tract Obstruction in Takotsubo Cardiomyopathy

(2015) Tetsuma Kawaji et al.   CIRCULATION JOURNAL

Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology

(2015) Alexander R. Lyon et al.   EUROPEAN JOURNAL OF HEART FAILURE

Myocardial edema as a substrate of electrocardiographic abnormalities and life-threatening arrhythmias in reversible ventricular dysfunction of takotsubo cardiomyopathy: Imaging evidence, presumed mechanisms, and implications for therapy

(2015) Federico Migliore et al.   HEART RHYTHM

Takotsubo cardiomyopathy, a new concept of cardiomyopathy: Clinical features and pathophysiology

(2015) Tsutomu Yoshikawa   INTERNATIONAL JOURNAL OF CARDIOLOGY

17-year trends in incidence and prognosis of cardiogenic shock in patients with acute myocardial infarction in western Sweden

(2015) B. Redfors et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Evidence of nitrosative stress within hearts of patients dying of Tako-tsubo cardiomyopathy

(2015) S.Y. Surikow et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mortality in takotsubo syndrome is similar to mortality in myocardial infarction — A report from the SWEDEHEART11Swedish web system for enhancement of evidence-based care in heart disease evaluated according to recommended therapies. registry

(2015) Björn Redfors et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

G-protein-coupled receptor kinase 5 polymorphism and Takotsubo cardiomyopathy

(2015) Giuseppina Novo et al.   Journal of Cardiovascular Medicine

Epidemiology and pathophysiology of Takotsubo syndrome

(2015) Yoshihiro J. Akashi et al.   Nature Reviews Cardiology

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy

(2015) Christian Templin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tako-Tsubo Cardiomyopathy: A Heart Stressed Out of Energy?

(2015) Dana K. Dawson et al.   JACC-Cardiovascular Imaging

Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle

(2014) Sander Land et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac CaM Kinase II Genes δ and γ Contribute to Adverse Remodeling but Redundantly Inhibit Calcineurin-Induced Myocardial Hypertrophy

(2014) Michael M. Kreusser et al.   CIRCULATION

Pathophysiology of Takotsubo Syndrome

(2014) Peter T. Wright et al.   CIRCULATION JOURNAL

J Wave and Fragmented QRS Formation During the Hyperacute Phase in Takotsubo Cardiomyopathy

(2014) Masato Shimizu et al.   CIRCULATION JOURNAL

Diagnosis of Takotsubo Cardiomyopathy

(2014) Dawn C Scantlebury et al.   CIRCULATION JOURNAL

Different catecholamines induce different patterns of takotsubo-like cardiac dysfunction in an apparently afterload dependent manner

(2014) Bjorn Redfors et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Why the current diagnostic criteria of Takotsubo syndrome are outmoded: A proposal for new criteria

(2014) John E. Madias   INTERNATIONAL JOURNAL OF CARDIOLOGY

Current hypotheses regarding the pathophysiology behind the takotsubo syndrome

(2014) Björn Redfors et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Revised clinical diagnostic criteria for Tako-tsubo syndrome: The Tako-tsubo Italian Network proposal

(2014) Guido Parodi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Complications in the clinical course of tako-tsubo cardiomyopathy

(2014) Birke Schneider et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Are ischemic stunning, conditioning, and “takotsubo” different sides to the same coin?

(2014) Björn Redfors et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Direct Evidences for Sympathetic Hyperactivity and Baroreflex Impairment in Tako Tsubo Cardiopathy

(2014) Angelica Vaccaro et al.   PLoS One

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling

(2014) Lorenz H. Lehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and Histological Assessment of an Experimental Model of Takotsubo's Cardiomyopathy

(2014) Jaspreet Sachdeva et al.   Journal of the American Heart Association

Impact of Pheochromocytoma on Left Ventricular Hypertrophy and QTc Prolongation: Comparison with Takotsubo Cardiomyopathy

(2014) Seon Yoon Choi et al.   Korean Circulation Journal

A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction

(2013) M. Jaguszewski et al.   EUROPEAN HEART JOURNAL

No association of G-protein-coupled receptor kinase 5 or β-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort

(2013) Gemma A. Figtree et al.   EUROPEAN JOURNAL OF HEART FAILURE

Novel rat model reveals important roles of β-adrenoreceptors in stress-induced cardiomyopathy

(2013) Yangzhen Shao et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Molecular basis of disturbed extracellular matrix homeostasis in stress cardiomyopathy

(2013) Sebastian Szardien et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Time course of electrocardiographic changes in transient left ventricular ballooning syndrome

(2013) Johan Bennett et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Burden of arrhythmias in patients with Takotsubo Cardiomyopathy (Apical Ballooning Syndrome)

(2013) Sadip Pant et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Are the different patterns of stress-induced (Takotsubo) cardiomyopathy explained by regional mechanical overload and demand: Supply mismatch in selected ventricular regions?

(2013) Bjorn Redfors et al.   MEDICAL HYPOTHESES

Myocardial oedema as the sole marker of acute injury in Takotsubo cardiomyopathy: a cardiovascular magnetic resonance (CMR) study

(2013) Ilaria Iacucci et al.   Radiologia Medica

Takotsubo Cardiomyopathy

(2013) Matthew H. Tranter et al.   Heart Failure Clinics

β-Adrenergic receptor subtype signaling in heart: From bench to bedside

(2012) Anthony Yiu Ho Woo et al.   ACTA PHARMACOLOGICA SINICA

Stress-Induced Cardiomyopathy in Sweden: Evidence for Different Ethnic Predisposition and Altered Cardio-Circulatory Status

(2012) Tomas Schultz et al.   CARDIOLOGY

Beta-Adrenergic Receptors, from Their Discovery and Characterization through Their Manipulation to Beneficial Clinical Application

(2012) S. Blake Wachter et al.   CARDIOLOGY

Stress Cardiomyopathy: A Syndrome of Catecholamine-Mediated Myocardial Stunning?

(2012) Ilan S. Wittstein   CELLULAR AND MOLECULAR NEUROBIOLOGY

Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging Identifies Sustained Regional Abnormalities in Cardiac Metabolism and Function in Stress-Induced Transient Midventricular Ballooning Syndrome

(2012) Tareq Ibrahim et al.   CIRCULATION

High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β 2 -Adrenergic Receptor/G i –Dependent Manner

(2012) Helen Paur et al.   CIRCULATION

Fatal stress-induced cardiomyopathy in a young patient treated with adrenomimetics

(2012) Bjorn Redfors et al.   Clinical Research in Cardiology

A mouse model reveals an important role for catecholamine-induced lipotoxicity in the pathogenesis of stress-induced cardiomyopathy

(2012) Yangzhen Shao et al.   EUROPEAN JOURNAL OF HEART FAILURE

Slowly resolving global myocardial inflammation/oedema in Tako-Tsubo cardiomyopathy: evidence from T2-weighted cardiac MRI

(2012) Christopher Neil et al.   HEART

Apicobasal gradient of left ventricular myocardial edema underlies transient T-wave inversion and QT interval prolongation (Wellens’ ECG pattern) in Tako-Tsubo cardiomyopathy

(2012) Martina Perazzolo Marra et al.   HEART RHYTHM

Stress-induced cardiomyopathy in a patient with chronic spinal cord transection at the level of C5: Endocrinologically mediated catecholamine toxicity

(2012) Bjorn Redfors et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Guillain–Barré syndrome and catecholamine therapy. A potential risk for developing takotsubo cardiomyopathy?

(2012) Silvio Quick et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Incidence and management of life-threatening arrhythmias in Takotsubo syndrome

(2012) Federico Migliore et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Distinct Cellular and Subcellular Distributions of G Protein-Coupled Receptor Kinase and Arrestin Isoforms in the Striatum

(2012) Evgeny Bychkov et al.   PLoS One

Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis

(2011) Anna Fusco et al.   CELLULAR SIGNALLING

Takotsubo cardiomyopathy has a unique cardiac biomarker profile: NT-proBNP/myoglobin and NT-proBNP/troponin T ratios for the differential diagnosis of acute coronary syndromes and stress induced cardiomyopathy

(2011) Georg M. Frhlich et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Clinical Characteristics and Cardiovascular Magnetic Resonance Findings in Stress (Takotsubo) Cardiomyopathy

(2011) Ingo Eitel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4

(2011) Johannes Backs et al.   JOURNAL OF CELL BIOLOGY

Cardiovascular manifestations of phaeochromocytoma

(2011) Aleksander Prejbisz et al.   JOURNAL OF HYPERTENSION

Miocardiopatía de tako-tsubo iatrogénica secundaria a catecolaminas

(2011) Baltasar Laínez et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Ligand-directed signalling at β-adrenoceptors

(2010) Bronwyn A. Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

Acquired long QT syndrome from stress cardiomyopathy is associated with ventricular arrhythmias and torsades de pointes

(2010) Christopher Madias et al.   HEART RHYTHM

Mechanisms of stress (Takotsubo) cardiomyopathy

(2010) Holger M. Nef et al.   Nature Reviews Cardiology

L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome

(2009) Letizia Spinelli et al.   EUROPEAN JOURNAL OF HEART FAILURE

Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels

(2009) M Madhavan et al.   HEART

Agonist Dose-dependent Phosphorylation by Protein Kinase A and G Protein-coupled Receptor Kinase Regulates β2Adrenoceptor Coupling to GiProteins in Cardiomyocytes

(2009) Ruijie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Takotsubo cardiomyopathy and QT interval prolongation: who are the patients at risk for torsades de pointes?

(2009) Liat Samuelov-Kinori et al.   JOURNAL OF ELECTROCARDIOLOGY

Stress Cardiomyopathy After Intravenous Administration of Catecholamines and Beta-Receptor Agonists

(2009) Jacob Abraham et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Cardiac adrenergic control and atrial fibrillation

(2009) Antony J. Workman   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): A mimic of acute myocardial infarction

(2008) Abhiram Prasad et al.   AMERICAN HEART JOURNAL

Dobutamine stress echo-induced apical ballooning (Takotsubo) syndrome

(2008) R. Margey et al.   European Journal of Echocardiography

A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure

(2008) Stephen B Liggett et al.   NATURE MEDICINE

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

(2008) J. S. Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Release of Catecholamines From the Hearts of Patients With Tako-Tsubo-Like Left Ventricular Dysfunction

(2007) Teruyoshi Kume et al.   CIRCULATION JOURNAL

Expression profiling of cardiac genes in Tako-Tsubo cardiomyopathy: Insight into a new cardiac entity

(2007) Holger M. Nef et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning

(2007) Alexander R Lyon et al.   Nature clinical practice. Cardiovascular medicine